Tags

Type your tag names separated by a space and hit enter

Impact of low high-density lipoproteins on in-hospital events and one-year clinical outcomes in patients with non-ST-elevation myocardial infarction acute coronary syndrome treated with drug-eluting stent implantation.
Am J Cardiol. 2006 Sep 15; 98(6):711-7.AJ

Abstract

High-density lipoprotein (HDL) cholesterol has protective cardiovascular effects. We investigated the effect of baseline HDL cholesterol on the outcomes of patients who underwent drug-eluting stent implantation for acute coronary syndrome. Since March 2003, 1,032 consecutive patients were, according to their baseline HDL cholesterol level, included in a low HDL cholesterol group (n = 550, <40 mg/dl in men, <45 mg/dl in women, mean 32 +/- 7) or a high HDL cholesterol group (n = 482, >40 mg/dl in men, >45 mg/dl in women, mean 55 +/- 19). End points were death, Q-wave myocardial infarction, target lesion revascularization, and a composite of major adverse cardiac events at 30 days and 1 year. We assessed the relation between HDL cholesterol and end points. Patients with low HDL cholesterol more often had diabetes, a higher body mass index, higher triglyceride levels, and lower total cholesterol levels. Low-density lipoprotein cholesterol and statin treatment (98% in the 2 groups) were comparable. Incidences of mortality and major adverse cardiac events at 30 days were higher in the low than in the high HDL cholesterol group (p <0.001 and p = 0.002, respectively; chi-square analysis). At 1 year, more deaths occurred in the low HDL cholesterol group (p <0.001; chi-square analysis), as did major adverse cardiac events (p <0.001; chi-square analysis). Multivariate analysis showed low HDL cholesterol at baseline (hazard ratio 2.61, 95% confidence interval 1.33 to 5.12) to be a key predictor of major adverse cardiac events and death (hazard ratio 3.33, 95% confidence interval 1.15 to 10.0) at 1 year. In conclusion, regardless of baseline low-density lipoprotein cholesterol levels and statin therapy, additional strategies to increase HDL cholesterol should be evaluated in patients with acute coronary syndrome.

Authors+Show Affiliations

The Division of Cardiology, Washington Hospital Center, Washington, DC, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16950168

Citation

Wolfram, Roswitha M., et al. "Impact of Low High-density Lipoproteins On In-hospital Events and One-year Clinical Outcomes in Patients With non-ST-elevation Myocardial Infarction Acute Coronary Syndrome Treated With Drug-eluting Stent Implantation." The American Journal of Cardiology, vol. 98, no. 6, 2006, pp. 711-7.
Wolfram RM, Brewer HB, Xue Z, et al. Impact of low high-density lipoproteins on in-hospital events and one-year clinical outcomes in patients with non-ST-elevation myocardial infarction acute coronary syndrome treated with drug-eluting stent implantation. Am J Cardiol. 2006;98(6):711-7.
Wolfram, R. M., Brewer, H. B., Xue, Z., Satler, L. F., Pichard, A. D., Kent, K. M., & Waksman, R. (2006). Impact of low high-density lipoproteins on in-hospital events and one-year clinical outcomes in patients with non-ST-elevation myocardial infarction acute coronary syndrome treated with drug-eluting stent implantation. The American Journal of Cardiology, 98(6), 711-7.
Wolfram RM, et al. Impact of Low High-density Lipoproteins On In-hospital Events and One-year Clinical Outcomes in Patients With non-ST-elevation Myocardial Infarction Acute Coronary Syndrome Treated With Drug-eluting Stent Implantation. Am J Cardiol. 2006 Sep 15;98(6):711-7. PubMed PMID: 16950168.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of low high-density lipoproteins on in-hospital events and one-year clinical outcomes in patients with non-ST-elevation myocardial infarction acute coronary syndrome treated with drug-eluting stent implantation. AU - Wolfram,Roswitha M, AU - Brewer,H Bryan, AU - Xue,Zhenyi, AU - Satler,Lowell F, AU - Pichard,Augusto D, AU - Kent,Kenneth M, AU - Waksman,Ron, Y1 - 2006/07/17/ PY - 2006/02/15/received PY - 2006/04/06/revised PY - 2006/04/06/accepted PY - 2006/9/5/pubmed PY - 2006/10/26/medline PY - 2006/9/5/entrez SP - 711 EP - 7 JF - The American journal of cardiology JO - Am J Cardiol VL - 98 IS - 6 N2 - High-density lipoprotein (HDL) cholesterol has protective cardiovascular effects. We investigated the effect of baseline HDL cholesterol on the outcomes of patients who underwent drug-eluting stent implantation for acute coronary syndrome. Since March 2003, 1,032 consecutive patients were, according to their baseline HDL cholesterol level, included in a low HDL cholesterol group (n = 550, <40 mg/dl in men, <45 mg/dl in women, mean 32 +/- 7) or a high HDL cholesterol group (n = 482, >40 mg/dl in men, >45 mg/dl in women, mean 55 +/- 19). End points were death, Q-wave myocardial infarction, target lesion revascularization, and a composite of major adverse cardiac events at 30 days and 1 year. We assessed the relation between HDL cholesterol and end points. Patients with low HDL cholesterol more often had diabetes, a higher body mass index, higher triglyceride levels, and lower total cholesterol levels. Low-density lipoprotein cholesterol and statin treatment (98% in the 2 groups) were comparable. Incidences of mortality and major adverse cardiac events at 30 days were higher in the low than in the high HDL cholesterol group (p <0.001 and p = 0.002, respectively; chi-square analysis). At 1 year, more deaths occurred in the low HDL cholesterol group (p <0.001; chi-square analysis), as did major adverse cardiac events (p <0.001; chi-square analysis). Multivariate analysis showed low HDL cholesterol at baseline (hazard ratio 2.61, 95% confidence interval 1.33 to 5.12) to be a key predictor of major adverse cardiac events and death (hazard ratio 3.33, 95% confidence interval 1.15 to 10.0) at 1 year. In conclusion, regardless of baseline low-density lipoprotein cholesterol levels and statin therapy, additional strategies to increase HDL cholesterol should be evaluated in patients with acute coronary syndrome. SN - 0002-9149 UR - https://www.unboundmedicine.com/medline/citation/16950168/Impact_of_low_high_density_lipoproteins_on_in_hospital_events_and_one_year_clinical_outcomes_in_patients_with_non_ST_elevation_myocardial_infarction_acute_coronary_syndrome_treated_with_drug_eluting_stent_implantation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(06)01059-9 DB - PRIME DP - Unbound Medicine ER -