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Human rhinovirus in bronchial epithelium of infants with recurrent respiratory symptoms.
J Allergy Clin Immunol. 2006 Sep; 118(3):591-6.JA

Abstract

BACKGROUND

Human rhinoviruses (HRVs) are a common cause of upper respiratory tract infections. There is growing evidence that HRVs are also important in lower respiratory tract infections and often induce asthma exacerbations.

OBJECTIVE

We evaluated the presence of HRV in the lower respiratory tract by obtaining bronchial biopsies from infants with recurrent asthmalike respiratory symptoms.

METHODS

A total of 201 steroid-naive infants age 3 to 26 months with recurrent respiratory symptoms for at least 4 weeks within the preceding 2 months were studied for lung function using body plethysmography. Bronchoscopy was performed in 68 children, and bronchial biopsies were available from 59 infants for HRV detection with in situ hybridization.

RESULTS

Human rhinovirus was detected in 21 of 47 (45%) specimens. Abnormal lung function (decreased airways conductance) was found in 18 of 21 (86%) HRV(+) infants and in 15 of 26 (58%) HRV(-) infants (P = .037). Occurrence of a respiratory infection in the 6 weeks preceding bronchoscopy correlated with HRV positivity (P = .036).

CONCLUSION

Human rhinovirus is frequently found in the lower airways in infants with recurrent respiratory symptoms, and the majority of these HRV(+) infants also showed increased airway resistance.

CLINICAL IMPLICATIONS

Human rhinovirus is a common pathogen causing upper and lower respiratory symptoms. Follow-up of these infants will reveal whether the presence of HRV in the bronchial biopsy and abnormal lung function with recurrent respiratory symptoms predicts subsequent asthma.

Authors+Show Affiliations

Department of Allergy, Helsinki University Central Hospital, Finland. kristina.malmstrom@pp.fimnet.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16950276

Citation

Malmström, Kristiina, et al. "Human Rhinovirus in Bronchial Epithelium of Infants With Recurrent Respiratory Symptoms." The Journal of Allergy and Clinical Immunology, vol. 118, no. 3, 2006, pp. 591-6.
Malmström K, Pitkäranta A, Carpen O, et al. Human rhinovirus in bronchial epithelium of infants with recurrent respiratory symptoms. J Allergy Clin Immunol. 2006;118(3):591-6.
Malmström, K., Pitkäranta, A., Carpen, O., Pelkonen, A., Malmberg, L. P., Turpeinen, M., Kajosaari, M., Sarna, S., Lindahl, H., Haahtela, T., & Mäkelä, M. J. (2006). Human rhinovirus in bronchial epithelium of infants with recurrent respiratory symptoms. The Journal of Allergy and Clinical Immunology, 118(3), 591-6.
Malmström K, et al. Human Rhinovirus in Bronchial Epithelium of Infants With Recurrent Respiratory Symptoms. J Allergy Clin Immunol. 2006;118(3):591-6. PubMed PMID: 16950276.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human rhinovirus in bronchial epithelium of infants with recurrent respiratory symptoms. AU - Malmström,Kristiina, AU - Pitkäranta,Anne, AU - Carpen,Olli, AU - Pelkonen,Anna, AU - Malmberg,L Pekka, AU - Turpeinen,Markku, AU - Kajosaari,Merja, AU - Sarna,Seppo, AU - Lindahl,Harry, AU - Haahtela,Tari, AU - Mäkelä,Mika J, Y1 - 2006/06/21/ PY - 2005/11/04/received PY - 2006/03/20/revised PY - 2006/04/04/accepted PY - 2006/9/5/pubmed PY - 2006/10/18/medline PY - 2006/9/5/entrez SP - 591 EP - 6 JF - The Journal of allergy and clinical immunology JO - J Allergy Clin Immunol VL - 118 IS - 3 N2 - BACKGROUND: Human rhinoviruses (HRVs) are a common cause of upper respiratory tract infections. There is growing evidence that HRVs are also important in lower respiratory tract infections and often induce asthma exacerbations. OBJECTIVE: We evaluated the presence of HRV in the lower respiratory tract by obtaining bronchial biopsies from infants with recurrent asthmalike respiratory symptoms. METHODS: A total of 201 steroid-naive infants age 3 to 26 months with recurrent respiratory symptoms for at least 4 weeks within the preceding 2 months were studied for lung function using body plethysmography. Bronchoscopy was performed in 68 children, and bronchial biopsies were available from 59 infants for HRV detection with in situ hybridization. RESULTS: Human rhinovirus was detected in 21 of 47 (45%) specimens. Abnormal lung function (decreased airways conductance) was found in 18 of 21 (86%) HRV(+) infants and in 15 of 26 (58%) HRV(-) infants (P = .037). Occurrence of a respiratory infection in the 6 weeks preceding bronchoscopy correlated with HRV positivity (P = .036). CONCLUSION: Human rhinovirus is frequently found in the lower airways in infants with recurrent respiratory symptoms, and the majority of these HRV(+) infants also showed increased airway resistance. CLINICAL IMPLICATIONS: Human rhinovirus is a common pathogen causing upper and lower respiratory symptoms. Follow-up of these infants will reveal whether the presence of HRV in the bronchial biopsy and abnormal lung function with recurrent respiratory symptoms predicts subsequent asthma. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/16950276/Human_rhinovirus_in_bronchial_epithelium_of_infants_with_recurrent_respiratory_symptoms_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-6749(06)00919-5 DB - PRIME DP - Unbound Medicine ER -