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Differential allergen sensitization patterns in chestnut allergy with or without associated latex-fruit syndrome.
J Allergy Clin Immunol 2006; 118(3):705-10JA

Abstract

BACKGROUND

Chestnut allergy has been almost exclusively considered in the context of the latex-fruit syndrome. Chestnut allergens not linked to latex hypersensitivity have not been studied.

OBJECTIVE

We sought to explore whether differences in sensitization patterns between chestnut allergy with or without associated latex-fruit syndrome can be detected.

METHODS

Twelve patients sensitized to chestnut but not to latex and 3 control patients with latex-chestnut allergy were analyzed. A major chestnut allergen was purified and characterized. IgE immunoblotting, specific IgE determination, and skin prick tests with 5 isolated allergens involved in food allergy or latex-fruit syndrome were also performed.

RESULTS

A major 9-kd allergen was detected in chestnut extract, isolated, and identified as lipid transfer protein (LTP) Cas s 8. Specific IgE to this allergen was found in 91% (by means of IgE immunoblotting) and 58% (by means of ELISA) of sera from patients with chestnut but not latex allergy. Moreover, 66% of these patients had positive skin prick test responses to Cas s 8. Additionally, allergenic LTPs from peach fruit and Artemisia vulgaris pollen were also reactive. In contrast, avocado class I chitinase and latex hevein, allergens associated with the latex-fruit syndrome, showed no reaction. The opposite situation was exhibited by patients with latex-chestnut allergy.

CONCLUSIONS

Patients with chestnut allergy with or without associated latex hypersensitivity present different patterns of major allergens (LTPs and class I chitinases, respectively).

CLINICAL IMPLICATIONS

LTPs and class I chitinases can be used as diagnostic tools in patients with chestnut allergy to predict whether an associated latex sensitization and a risk of potential cross-reactivity with other plant foods and pollens exist.

Authors+Show Affiliations

Unidad de Bioquímica, Departamento de Biotecnología, E.T.S. Ingenieros Agrónomos, UPM, Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16950291

Citation

Sánchez-Monge, Rosa, et al. "Differential Allergen Sensitization Patterns in Chestnut Allergy With or Without Associated Latex-fruit Syndrome." The Journal of Allergy and Clinical Immunology, vol. 118, no. 3, 2006, pp. 705-10.
Sánchez-Monge R, Blanco C, López-Torrejón G, et al. Differential allergen sensitization patterns in chestnut allergy with or without associated latex-fruit syndrome. J Allergy Clin Immunol. 2006;118(3):705-10.
Sánchez-Monge, R., Blanco, C., López-Torrejón, G., Cumplido, J., Recas, M., Figueroa, J., ... Salcedo, G. (2006). Differential allergen sensitization patterns in chestnut allergy with or without associated latex-fruit syndrome. The Journal of Allergy and Clinical Immunology, 118(3), pp. 705-10.
Sánchez-Monge R, et al. Differential Allergen Sensitization Patterns in Chestnut Allergy With or Without Associated Latex-fruit Syndrome. J Allergy Clin Immunol. 2006;118(3):705-10. PubMed PMID: 16950291.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential allergen sensitization patterns in chestnut allergy with or without associated latex-fruit syndrome. AU - Sánchez-Monge,Rosa, AU - Blanco,Carlos, AU - López-Torrejón,Gema, AU - Cumplido,Jose, AU - Recas,Munia, AU - Figueroa,Javier, AU - Carrillo,Teresa, AU - Salcedo,Gabriel, Y1 - 2006/06/27/ PY - 2006/03/30/received PY - 2006/04/21/revised PY - 2006/04/21/accepted PY - 2006/9/5/pubmed PY - 2006/10/18/medline PY - 2006/9/5/entrez SP - 705 EP - 10 JF - The Journal of allergy and clinical immunology JO - J. Allergy Clin. Immunol. VL - 118 IS - 3 N2 - BACKGROUND: Chestnut allergy has been almost exclusively considered in the context of the latex-fruit syndrome. Chestnut allergens not linked to latex hypersensitivity have not been studied. OBJECTIVE: We sought to explore whether differences in sensitization patterns between chestnut allergy with or without associated latex-fruit syndrome can be detected. METHODS: Twelve patients sensitized to chestnut but not to latex and 3 control patients with latex-chestnut allergy were analyzed. A major chestnut allergen was purified and characterized. IgE immunoblotting, specific IgE determination, and skin prick tests with 5 isolated allergens involved in food allergy or latex-fruit syndrome were also performed. RESULTS: A major 9-kd allergen was detected in chestnut extract, isolated, and identified as lipid transfer protein (LTP) Cas s 8. Specific IgE to this allergen was found in 91% (by means of IgE immunoblotting) and 58% (by means of ELISA) of sera from patients with chestnut but not latex allergy. Moreover, 66% of these patients had positive skin prick test responses to Cas s 8. Additionally, allergenic LTPs from peach fruit and Artemisia vulgaris pollen were also reactive. In contrast, avocado class I chitinase and latex hevein, allergens associated with the latex-fruit syndrome, showed no reaction. The opposite situation was exhibited by patients with latex-chestnut allergy. CONCLUSIONS: Patients with chestnut allergy with or without associated latex hypersensitivity present different patterns of major allergens (LTPs and class I chitinases, respectively). CLINICAL IMPLICATIONS: LTPs and class I chitinases can be used as diagnostic tools in patients with chestnut allergy to predict whether an associated latex sensitization and a risk of potential cross-reactivity with other plant foods and pollens exist. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/16950291/Differential_allergen_sensitization_patterns_in_chestnut_allergy_with_or_without_associated_latex_fruit_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-6749(06)01147-X DB - PRIME DP - Unbound Medicine ER -