Tags

Type your tag names separated by a space and hit enter

Hyperresponsive TH2 cells with enhanced nuclear factor-kappa B activation induce atopic dermatitis-like skin lesions in Nishiki-nezumi Cinnamon/Nagoya mice.
J Allergy Clin Immunol. 2006 Sep; 118(3):725-33.JA

Abstract

BACKGROUND

Nishiki-nezumi Cinnamon/Nagoya (NC/Nga) mice raised in nonair-controlled conventional circumstances spontaneously develop atopic dermatitis-like skin lesions; however, the underlying mechanisms remain unclear.

OBJECTIVE

We wanted to identify the critical intracellular signaling molecules in T cells that induce atopic dermatitis-like skin legions in NC/Nga mice.

METHODS

We examined the levels of signal transduction and cytokine production in T cells, particularly those in atopic dermatitis-like lesions induced by the topical injection of mite antigens in NC/Nga mice under specific pathogen-free conditions.

RESULTS

In NC/Nga mice maintained under specific pathogen-free conditions, the capability of T(H)1/T(H)2 and T cytotoxic 1/T cytotoxic 2 (Tc1/Tc2) cell differentiation increased significantly. T-cell antigen receptor-mediated activation of the extracellular signal-regulated kinase/mitogen-activated protein kinase cascade and nuclear factor-kappaB (NF-kappaB) signaling were enhanced in NC/Nga T cells. The expression of T(H)2 cytokines (IL-4, IL-13, and IL-5) and that of GATA-binding protein 3 (GATA3), avian musculoaponeurotic fibrosarcoma (c-Maf), NF-kappaB, and activator protein 1 (AP1) selectively increased in draining lymph node T cells of NC/Nga mice. Moreover, the cell transfer of inhibitory NF-kappaB mutant-infected T(H)2 cells reduced ear thickness in the mite antigen-induced skin lesion of NC/Nga mice.

CONCLUSION

Hyperresponsive T(H)2 cells with an enhanced activity of NF-kappaB and AP1 play a crucial role in the pathogenesis of atopic dermatitis-like skin lesions in NC/Nga mice.

CLINICAL IMPLICATIONS

These results indicate potential therapeutic usefulness of developing selective inhibitors for NF-kappaB in the treatment of human atopic dermatitis.

Authors+Show Affiliations

Department of Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16950294

Citation

Tenda, Yoshiyuki, et al. "Hyperresponsive TH2 Cells With Enhanced Nuclear Factor-kappa B Activation Induce Atopic Dermatitis-like Skin Lesions in Nishiki-nezumi Cinnamon/Nagoya Mice." The Journal of Allergy and Clinical Immunology, vol. 118, no. 3, 2006, pp. 725-33.
Tenda Y, Yamashita M, Kimura MY, et al. Hyperresponsive TH2 cells with enhanced nuclear factor-kappa B activation induce atopic dermatitis-like skin lesions in Nishiki-nezumi Cinnamon/Nagoya mice. J Allergy Clin Immunol. 2006;118(3):725-33.
Tenda, Y., Yamashita, M., Kimura, M. Y., Hasegawa, A., Shimizu, C., Kitajima, M., Onodera, A., Suzuki, A., Seki, N., & Nakayama, T. (2006). Hyperresponsive TH2 cells with enhanced nuclear factor-kappa B activation induce atopic dermatitis-like skin lesions in Nishiki-nezumi Cinnamon/Nagoya mice. The Journal of Allergy and Clinical Immunology, 118(3), 725-33.
Tenda Y, et al. Hyperresponsive TH2 Cells With Enhanced Nuclear Factor-kappa B Activation Induce Atopic Dermatitis-like Skin Lesions in Nishiki-nezumi Cinnamon/Nagoya Mice. J Allergy Clin Immunol. 2006;118(3):725-33. PubMed PMID: 16950294.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperresponsive TH2 cells with enhanced nuclear factor-kappa B activation induce atopic dermatitis-like skin lesions in Nishiki-nezumi Cinnamon/Nagoya mice. AU - Tenda,Yoshiyuki, AU - Yamashita,Masakatsu, AU - Kimura,Motoko Y, AU - Hasegawa,Akihiro, AU - Shimizu,Chiori, AU - Kitajima,Masayuki, AU - Onodera,Atsushi, AU - Suzuki,Akane, AU - Seki,Nobuo, AU - Nakayama,Toshinori, Y1 - 2006/07/28/ PY - 2005/12/26/received PY - 2006/05/16/revised PY - 2006/05/23/accepted PY - 2006/9/5/pubmed PY - 2006/10/18/medline PY - 2006/9/5/entrez SP - 725 EP - 33 JF - The Journal of allergy and clinical immunology JO - J Allergy Clin Immunol VL - 118 IS - 3 N2 - BACKGROUND: Nishiki-nezumi Cinnamon/Nagoya (NC/Nga) mice raised in nonair-controlled conventional circumstances spontaneously develop atopic dermatitis-like skin lesions; however, the underlying mechanisms remain unclear. OBJECTIVE: We wanted to identify the critical intracellular signaling molecules in T cells that induce atopic dermatitis-like skin legions in NC/Nga mice. METHODS: We examined the levels of signal transduction and cytokine production in T cells, particularly those in atopic dermatitis-like lesions induced by the topical injection of mite antigens in NC/Nga mice under specific pathogen-free conditions. RESULTS: In NC/Nga mice maintained under specific pathogen-free conditions, the capability of T(H)1/T(H)2 and T cytotoxic 1/T cytotoxic 2 (Tc1/Tc2) cell differentiation increased significantly. T-cell antigen receptor-mediated activation of the extracellular signal-regulated kinase/mitogen-activated protein kinase cascade and nuclear factor-kappaB (NF-kappaB) signaling were enhanced in NC/Nga T cells. The expression of T(H)2 cytokines (IL-4, IL-13, and IL-5) and that of GATA-binding protein 3 (GATA3), avian musculoaponeurotic fibrosarcoma (c-Maf), NF-kappaB, and activator protein 1 (AP1) selectively increased in draining lymph node T cells of NC/Nga mice. Moreover, the cell transfer of inhibitory NF-kappaB mutant-infected T(H)2 cells reduced ear thickness in the mite antigen-induced skin lesion of NC/Nga mice. CONCLUSION: Hyperresponsive T(H)2 cells with an enhanced activity of NF-kappaB and AP1 play a crucial role in the pathogenesis of atopic dermatitis-like skin lesions in NC/Nga mice. CLINICAL IMPLICATIONS: These results indicate potential therapeutic usefulness of developing selective inhibitors for NF-kappaB in the treatment of human atopic dermatitis. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/16950294/Hyperresponsive_TH2_cells_with_enhanced_nuclear_factor_kappa_B_activation_induce_atopic_dermatitis_like_skin_lesions_in_Nishiki_nezumi_Cinnamon/Nagoya_mice_ DB - PRIME DP - Unbound Medicine ER -