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Fluoroquinolone resistance in Salmonella typhi and S. paratyphi A in Bangalore, India.
Trans R Soc Trop Med Hyg. 2007 Mar; 101(3):308-10.TR

Abstract

Fluoroquinolone resistance in Salmonella typhi and S. paratyphi A is being increasingly reported. The minimum inhibitory concentrations (MICs) of ciprofloxacin, ofloxacin, levofloxacin and gatifloxacin against S. typhi and S. paratyphi A were compared. Fifty blood culture isolates, 25 S. typhi and 25 S. paratyphi A, were studied. The MICs were determined by the agar dilution method. Disc diffusion was done for the fluoroquinolones and other antibiotics. Nalidixic acid resistance was seen in 21/25 S. paratyphi A and 17/25 S. typhi isolates, and these had higher MICs to fluoroquinolones. Five S. typhi and six S. paratyphi A were fully resistant to ciprofloxacin (MIC >2 microg/l). No multidrug resistance was seen in S. typhi. The absence of multidrug resistance and presence of fluoroquinolone resistance warrants a review of therapy for enteric fever.

Authors+Show Affiliations

Department of Microbiology, Manipal Hospital, 98 Rustom Bagh, Airport Road, Bangalore 560017, India. sangeeta.joshi@manipalhospital.orgNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16950486

Citation

Joshi, S, and S K. Amarnath. "Fluoroquinolone Resistance in Salmonella Typhi and S. Paratyphi a in Bangalore, India." Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 101, no. 3, 2007, pp. 308-10.
Joshi S, Amarnath SK. Fluoroquinolone resistance in Salmonella typhi and S. paratyphi A in Bangalore, India. Trans R Soc Trop Med Hyg. 2007;101(3):308-10.
Joshi, S., & Amarnath, S. K. (2007). Fluoroquinolone resistance in Salmonella typhi and S. paratyphi A in Bangalore, India. Transactions of the Royal Society of Tropical Medicine and Hygiene, 101(3), 308-10.
Joshi S, Amarnath SK. Fluoroquinolone Resistance in Salmonella Typhi and S. Paratyphi a in Bangalore, India. Trans R Soc Trop Med Hyg. 2007;101(3):308-10. PubMed PMID: 16950486.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fluoroquinolone resistance in Salmonella typhi and S. paratyphi A in Bangalore, India. AU - Joshi,S, AU - Amarnath,S K, Y1 - 2006/09/06/ PY - 2006/02/03/received PY - 2006/04/29/revised PY - 2006/05/02/accepted PY - 2006/9/5/pubmed PY - 2007/9/12/medline PY - 2006/9/5/entrez SP - 308 EP - 10 JF - Transactions of the Royal Society of Tropical Medicine and Hygiene JO - Trans R Soc Trop Med Hyg VL - 101 IS - 3 N2 - Fluoroquinolone resistance in Salmonella typhi and S. paratyphi A is being increasingly reported. The minimum inhibitory concentrations (MICs) of ciprofloxacin, ofloxacin, levofloxacin and gatifloxacin against S. typhi and S. paratyphi A were compared. Fifty blood culture isolates, 25 S. typhi and 25 S. paratyphi A, were studied. The MICs were determined by the agar dilution method. Disc diffusion was done for the fluoroquinolones and other antibiotics. Nalidixic acid resistance was seen in 21/25 S. paratyphi A and 17/25 S. typhi isolates, and these had higher MICs to fluoroquinolones. Five S. typhi and six S. paratyphi A were fully resistant to ciprofloxacin (MIC >2 microg/l). No multidrug resistance was seen in S. typhi. The absence of multidrug resistance and presence of fluoroquinolone resistance warrants a review of therapy for enteric fever. SN - 0035-9203 UR - https://www.unboundmedicine.com/medline/citation/16950486/Fluoroquinolone_resistance_in_Salmonella_typhi_and_S__paratyphi_A_in_Bangalore_India_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0035-9203(06)00204-5 DB - PRIME DP - Unbound Medicine ER -