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Anti-inflammatory activity of hexane leaf extract of Aspilia africana C.D. Adams.
J Ethnopharmacol. 2007 Jan 19; 109(2):219-25.JE

Abstract

The anti-inflammatory activity of hexane leaf extract of Aspilia africana C.D. Adams (Compositae) was evaluated in rodents using the xylene-induced ear edema, egg albumin- and agar-induced paw edema, formaldehyde-induced arthritis, cotton pellet granuloma, gastric ulcerogenic, acetic acid-induced vascular permeability and dextran-induced in vivo leukocyte migration tests. Results showed that the extract (5mg/ear) inhibited topical edema in the mouse ear and at 200 and 400mg/kg (i.p.), it significantly (P<0.05) suppressed the development of egg albumin- and agar-induced paw edema, and the global edematous response to arthritis induced by formaldehyde in rats. Oral administration of the extract (200 or 400mg/kg) evoked a significant (P<0.05) dose-related ulceration of the rat gastric mucosa and inhibition of vascular permeability induced by acetic acid in mice. The extract also significantly (P<0.05) reduced total leukocyte and neutrophils counts in a non-dose-related manner. However, it significantly (P<0.05) increased lymphocyte counts and stimulated the growth of granuloma tissues induced by subcutaneously implanted cotton pellets in rats. Phytochemical tests showed that the extract contained sterols and terpenoids. These findings suggest that the leaves of Aspilia africana possess anti-inflammatory activity in acute and certain aspects of chronic inflammation, which may derive from inhibition of prostaglandins synthesis, inhibition of increased vascular permeability, inhibition of neutrophil migration into inflamed tissues, and stimulation of lymphocyte accumulation, which may enhance tissue repair and healing. The terpenoids present in the leaves may account for the anti-inflammatory activity.

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Authors+Show Affiliations

Okoli CO
Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria. charlesokoli@hotmail.com
Akah PA
No affiliation info available
Nwafor SV
No affiliation info available
Anisiobi AI
No affiliation info available
Ibegbunam IN
No affiliation info available
Erojikwe O
No affiliation info available

MeSH

Administration, OralAdministration, TopicalAnimalsAnti-Inflammatory AgentsArthritisAsteraceaeDose-Response Relationship, DrugDrug Evaluation, PreclinicalEarEdemaFemaleGastric MucosaHexanesMaleMicePlant ExtractsPlant LeavesProstaglandinsRatsStomach UlcerTerpenes

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16950582

Citation

Okoli, C O., et al. "Anti-inflammatory Activity of Hexane Leaf Extract of Aspilia Africana C.D. Adams." Journal of Ethnopharmacology, vol. 109, no. 2, 2007, pp. 219-25.
Okoli CO, Akah PA, Nwafor SV, et al. Anti-inflammatory activity of hexane leaf extract of Aspilia africana C.D. Adams. J Ethnopharmacol. 2007;109(2):219-25.
Okoli, C. O., Akah, P. A., Nwafor, S. V., Anisiobi, A. I., Ibegbunam, I. N., & Erojikwe, O. (2007). Anti-inflammatory activity of hexane leaf extract of Aspilia africana C.D. Adams. Journal of Ethnopharmacology, 109(2), 219-25.
Okoli CO, et al. Anti-inflammatory Activity of Hexane Leaf Extract of Aspilia Africana C.D. Adams. J Ethnopharmacol. 2007 Jan 19;109(2):219-25. PubMed PMID: 16950582.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory activity of hexane leaf extract of Aspilia africana C.D. Adams. AU - Okoli,C O, AU - Akah,P A, AU - Nwafor,S V, AU - Anisiobi,A I, AU - Ibegbunam,I N, AU - Erojikwe,O, Y1 - 2006/08/07/ PY - 2005/04/04/received PY - 2006/04/24/revised PY - 2006/07/20/accepted PY - 2006/9/5/pubmed PY - 2007/4/6/medline PY - 2006/9/5/entrez SP - 219 EP - 25 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 109 IS - 2 N2 - The anti-inflammatory activity of hexane leaf extract of Aspilia africana C.D. Adams (Compositae) was evaluated in rodents using the xylene-induced ear edema, egg albumin- and agar-induced paw edema, formaldehyde-induced arthritis, cotton pellet granuloma, gastric ulcerogenic, acetic acid-induced vascular permeability and dextran-induced in vivo leukocyte migration tests. Results showed that the extract (5mg/ear) inhibited topical edema in the mouse ear and at 200 and 400mg/kg (i.p.), it significantly (P<0.05) suppressed the development of egg albumin- and agar-induced paw edema, and the global edematous response to arthritis induced by formaldehyde in rats. Oral administration of the extract (200 or 400mg/kg) evoked a significant (P<0.05) dose-related ulceration of the rat gastric mucosa and inhibition of vascular permeability induced by acetic acid in mice. The extract also significantly (P<0.05) reduced total leukocyte and neutrophils counts in a non-dose-related manner. However, it significantly (P<0.05) increased lymphocyte counts and stimulated the growth of granuloma tissues induced by subcutaneously implanted cotton pellets in rats. Phytochemical tests showed that the extract contained sterols and terpenoids. These findings suggest that the leaves of Aspilia africana possess anti-inflammatory activity in acute and certain aspects of chronic inflammation, which may derive from inhibition of prostaglandins synthesis, inhibition of increased vascular permeability, inhibition of neutrophil migration into inflamed tissues, and stimulation of lymphocyte accumulation, which may enhance tissue repair and healing. The terpenoids present in the leaves may account for the anti-inflammatory activity. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/16950582/Anti_inflammatory_activity_of_hexane_leaf_extract_of_Aspilia_africana_C_D__Adams_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(06)00374-6 DB - PRIME DP - Unbound Medicine ER -