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Metabolic hormones profile in 2 weeks old healthy infants of diabetic mothers.
Saudi Med J 2006; 27(9):1338-45SM

Abstract

OBJECTIVE

To determine the concentration of plasma leptin and other metabolic hormones in offspring of diabetic and none diabetic mothers after 2 weeks of age. The relationship between leptin and metabolic hormones was also investigated.

METHODS

Included in the study were 79 newborns from the Neonatal Unit at King Abdul-Aziz University Hospital, Jeddah, Kingdom of Saudi Arabia from January 2004-January 2005. The newborns were categorized into 3 main groups: the control group, consisting of 32 infants of non-diabetic mothers; the gestational diabetes mothers (GDM) group, consisting of 26 infants; and the frank diabetic mothers (FDM), consisting of 21 infants. Infants of diabetic mothers were further subdivided into those of dietary (d) or insulin (i) dependent mothers. Plasma leptin, insulin, cortisol and free thyroxin levels were measured by enzyme link immunosorbent assay.

RESULTS

No significant difference in plasma leptin was observed between the studied groups. The GDM-d and FDM-d showed lower glucose versus controls (p<0.001 and p<0.05). There was significant correlation between leptin and glucose in the GDM group (r=0.18, p< 0.05) and with insulin in GDM-d on diet control (r=0.37, p< 0.01).

CONCLUSION

After 2 weeks of life, no difference in plasma leptin between infants of diabetic and non-diabetic mothers was observed, which may be important for the stimulation of feeding behavior and acquisition of energy homeostasis. Significant association between plasma leptin and insulin in offspring of GDM supports the hypothesis that functional adipoinsular axis might exist in term newborns.

Authors+Show Affiliations

Department of Pediatrics, King Abdul-Aziz University Hospital, PO Box 17818, Jeddah 21494, Kingdom of Saudi Arabia. soad.jaber@gmail.com

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16951770

Citation

Jaber, Soad M.. "Metabolic Hormones Profile in 2 Weeks Old Healthy Infants of Diabetic Mothers." Saudi Medical Journal, vol. 27, no. 9, 2006, pp. 1338-45.
Jaber SM. Metabolic hormones profile in 2 weeks old healthy infants of diabetic mothers. Saudi Med J. 2006;27(9):1338-45.
Jaber, S. M. (2006). Metabolic hormones profile in 2 weeks old healthy infants of diabetic mothers. Saudi Medical Journal, 27(9), pp. 1338-45.
Jaber SM. Metabolic Hormones Profile in 2 Weeks Old Healthy Infants of Diabetic Mothers. Saudi Med J. 2006;27(9):1338-45. PubMed PMID: 16951770.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic hormones profile in 2 weeks old healthy infants of diabetic mothers. A1 - Jaber,Soad M, PY - 2006/9/5/pubmed PY - 2007/5/19/medline PY - 2006/9/5/entrez SP - 1338 EP - 45 JF - Saudi medical journal JO - Saudi Med J VL - 27 IS - 9 N2 - OBJECTIVE: To determine the concentration of plasma leptin and other metabolic hormones in offspring of diabetic and none diabetic mothers after 2 weeks of age. The relationship between leptin and metabolic hormones was also investigated. METHODS: Included in the study were 79 newborns from the Neonatal Unit at King Abdul-Aziz University Hospital, Jeddah, Kingdom of Saudi Arabia from January 2004-January 2005. The newborns were categorized into 3 main groups: the control group, consisting of 32 infants of non-diabetic mothers; the gestational diabetes mothers (GDM) group, consisting of 26 infants; and the frank diabetic mothers (FDM), consisting of 21 infants. Infants of diabetic mothers were further subdivided into those of dietary (d) or insulin (i) dependent mothers. Plasma leptin, insulin, cortisol and free thyroxin levels were measured by enzyme link immunosorbent assay. RESULTS: No significant difference in plasma leptin was observed between the studied groups. The GDM-d and FDM-d showed lower glucose versus controls (p<0.001 and p<0.05). There was significant correlation between leptin and glucose in the GDM group (r=0.18, p< 0.05) and with insulin in GDM-d on diet control (r=0.37, p< 0.01). CONCLUSION: After 2 weeks of life, no difference in plasma leptin between infants of diabetic and non-diabetic mothers was observed, which may be important for the stimulation of feeding behavior and acquisition of energy homeostasis. Significant association between plasma leptin and insulin in offspring of GDM supports the hypothesis that functional adipoinsular axis might exist in term newborns. SN - 0379-5284 UR - https://www.unboundmedicine.com/medline/citation/16951770/Metabolic_hormones_profile_in_2_weeks_old_healthy_infants_of_diabetic_mothers_ L2 - https://medlineplus.gov/diabetesmedicines.html DB - PRIME DP - Unbound Medicine ER -