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Clinical outcome of cystic fibrosis presenting with or without meconium ileus: a matched cohort study.
J Pediatr Surg 2006; 41(9):1556-60JP

Abstract

OBJECTIVE

This matched case-control study compared the nutritional and the pulmonary long-term outcomes of cystic fibrosis (CF) patients presenting a history of meconium ileus (MI) with early-diagnosed symptomatic CF without MI (non-MI).

MATERIAL AND METHOD

Twenty-six patients with CF treated for MI between 1980 and 1997 have been matched for sex, birth date, and earliest CF symptomatic diagnosis for the children with non-MI CF. Clinical characteristics, genotype and complications were evaluated as well as the progression of the CF disease from infancy to 15 years old by nutritional status (z score weight, z score height), pulmonary function tests (PFTs) (FVC and FEV1), and Pseudomonas aeruginosa acquisition.

RESULTS

Median duration of the follow-up was 12.5 years (range, 10-17 years). Genotype identification showed no significant difference. Further on, the rate of complications and the occurrence of chronic P. aeruginosa colonization did not differ. At age of 15 years (n = 13), nutritional status and PFTs did not demonstrate any significant difference.

CONCLUSION

These results suggest that adequate initial nutritional and medical management of MI allows further similar nutritional status and PFTs compared with other early-diagnosed symptomatic CF patients. In this study, MI did not represent an additional risk factor for the patient's life.

Authors+Show Affiliations

Cystic Fibrosis Centre, Hospital Robert Debré 48, bd Serurier, 75019 Paris, France. anne.munck@rdb.ap-hop-paris.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16952591

Citation

Munck, Anne, et al. "Clinical Outcome of Cystic Fibrosis Presenting With or Without Meconium Ileus: a Matched Cohort Study." Journal of Pediatric Surgery, vol. 41, no. 9, 2006, pp. 1556-60.
Munck A, Gérardin M, Alberti C, et al. Clinical outcome of cystic fibrosis presenting with or without meconium ileus: a matched cohort study. J Pediatr Surg. 2006;41(9):1556-60.
Munck, A., Gérardin, M., Alberti, C., Ajzenman, C., Lebourgeois, M., Aigrain, Y., & Navarro, J. (2006). Clinical outcome of cystic fibrosis presenting with or without meconium ileus: a matched cohort study. Journal of Pediatric Surgery, 41(9), pp. 1556-60.
Munck A, et al. Clinical Outcome of Cystic Fibrosis Presenting With or Without Meconium Ileus: a Matched Cohort Study. J Pediatr Surg. 2006;41(9):1556-60. PubMed PMID: 16952591.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical outcome of cystic fibrosis presenting with or without meconium ileus: a matched cohort study. AU - Munck,Anne, AU - Gérardin,Michèle, AU - Alberti,Corinne, AU - Ajzenman,Catherine, AU - Lebourgeois,Muriel, AU - Aigrain,Yves, AU - Navarro,Jean, PY - 2006/9/6/pubmed PY - 2006/9/30/medline PY - 2006/9/6/entrez SP - 1556 EP - 60 JF - Journal of pediatric surgery JO - J. Pediatr. Surg. VL - 41 IS - 9 N2 - OBJECTIVE: This matched case-control study compared the nutritional and the pulmonary long-term outcomes of cystic fibrosis (CF) patients presenting a history of meconium ileus (MI) with early-diagnosed symptomatic CF without MI (non-MI). MATERIAL AND METHOD: Twenty-six patients with CF treated for MI between 1980 and 1997 have been matched for sex, birth date, and earliest CF symptomatic diagnosis for the children with non-MI CF. Clinical characteristics, genotype and complications were evaluated as well as the progression of the CF disease from infancy to 15 years old by nutritional status (z score weight, z score height), pulmonary function tests (PFTs) (FVC and FEV1), and Pseudomonas aeruginosa acquisition. RESULTS: Median duration of the follow-up was 12.5 years (range, 10-17 years). Genotype identification showed no significant difference. Further on, the rate of complications and the occurrence of chronic P. aeruginosa colonization did not differ. At age of 15 years (n = 13), nutritional status and PFTs did not demonstrate any significant difference. CONCLUSION: These results suggest that adequate initial nutritional and medical management of MI allows further similar nutritional status and PFTs compared with other early-diagnosed symptomatic CF patients. In this study, MI did not represent an additional risk factor for the patient's life. SN - 1531-5037 UR - https://www.unboundmedicine.com/medline/citation/16952591/Clinical_outcome_of_cystic_fibrosis_presenting_with_or_without_meconium_ileus:_a_matched_cohort_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3468(06)00377-0 DB - PRIME DP - Unbound Medicine ER -