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Comparison of anthropometric, area- and volume-based assessment of abdominal subcutaneous and visceral adipose tissue volumes using multi-detector computed tomography.
Int J Obes (Lond). 2007 Mar; 31(3):500-6.IJ

Abstract

PURPOSE

Cross-sectional imaging may enable accurate localization and quantification of subcutaneous and visceral adipose tissue. The reproducibility of multi-detector computed tomography (MDCT)-based volumetric quantification of abdominal adipose tissue and the ability to depict age- and gender-related characteristics of adipose tissue deposition have not been reported.

METHODS

We evaluated a random subset of 100 Caucasian subjects (age range: 37-83 years; 49% women) of the Framingham Heart Study offspring cohort who underwent MDCT scanning. Two readers measured subcutaneous and visceral adipose tissue volumes (SAV and VAV; cm(3)) and areas (SAA and VAA; cm(2)) as well as abdominal sagital diameter (SD) and waist circumference (WC).

RESULTS

Inter-reader reproducibility was excellent (relative difference: -0.34+/-0.52% for SAV and 0.59+/-0.93% for VAV, intra-class correlation (ICC)=0.99 each). The mean SAA/VAA ratio was significantly different from the mean SAV/VAV ratio (2.0+/-1.2 vs 1.7+/-0.9; P<0.001). The ratio of SAV/VAV was only weakly inversely associated with SD (ICC=-0.32, P=0.01) and not significantly associated with WC (ICC=-0.14, P=0.14) or body mass index (ICC=-0.17, P=0.09). The mean SAV/VAV ratio was significantly different between participants <60 vs >60 years (1.9+/-1.0 vs 1.5+/-0.7; P<0.001) and between men and women (1.2+/-0.5 vs 2.2+/-0.9; P<0.001).

CONCLUSION

This study demonstrates that MDCT-based volumetric quantification of abdominal adipose tissue is highly reproducible. In addition, our results suggest that volumetric measurements can depict age- and gender-related differences of visceral and subcutaneous abdominal adipose tissue deposition. Further research is warranted to assess whether volumetric measurements may substantially improve the predictive value of obesity measures for insulin resistance, type 2 diabetes mellitus and other diseases.

Authors+Show Affiliations

Radiology Department, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16953256

Citation

Maurovich-Horvat, P, et al. "Comparison of Anthropometric, Area- and Volume-based Assessment of Abdominal Subcutaneous and Visceral Adipose Tissue Volumes Using Multi-detector Computed Tomography." International Journal of Obesity (2005), vol. 31, no. 3, 2007, pp. 500-6.
Maurovich-Horvat P, Massaro J, Fox CS, et al. Comparison of anthropometric, area- and volume-based assessment of abdominal subcutaneous and visceral adipose tissue volumes using multi-detector computed tomography. Int J Obes (Lond). 2007;31(3):500-6.
Maurovich-Horvat, P., Massaro, J., Fox, C. S., Moselewski, F., O'Donnell, C. J., & Hoffmann, U. (2007). Comparison of anthropometric, area- and volume-based assessment of abdominal subcutaneous and visceral adipose tissue volumes using multi-detector computed tomography. International Journal of Obesity (2005), 31(3), 500-6.
Maurovich-Horvat P, et al. Comparison of Anthropometric, Area- and Volume-based Assessment of Abdominal Subcutaneous and Visceral Adipose Tissue Volumes Using Multi-detector Computed Tomography. Int J Obes (Lond). 2007;31(3):500-6. PubMed PMID: 16953256.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of anthropometric, area- and volume-based assessment of abdominal subcutaneous and visceral adipose tissue volumes using multi-detector computed tomography. AU - Maurovich-Horvat,P, AU - Massaro,J, AU - Fox,C S, AU - Moselewski,F, AU - O'Donnell,C J, AU - Hoffmann,U, Y1 - 2006/09/05/ PY - 2006/9/6/pubmed PY - 2007/6/8/medline PY - 2006/9/6/entrez SP - 500 EP - 6 JF - International journal of obesity (2005) JO - Int J Obes (Lond) VL - 31 IS - 3 N2 - PURPOSE: Cross-sectional imaging may enable accurate localization and quantification of subcutaneous and visceral adipose tissue. The reproducibility of multi-detector computed tomography (MDCT)-based volumetric quantification of abdominal adipose tissue and the ability to depict age- and gender-related characteristics of adipose tissue deposition have not been reported. METHODS: We evaluated a random subset of 100 Caucasian subjects (age range: 37-83 years; 49% women) of the Framingham Heart Study offspring cohort who underwent MDCT scanning. Two readers measured subcutaneous and visceral adipose tissue volumes (SAV and VAV; cm(3)) and areas (SAA and VAA; cm(2)) as well as abdominal sagital diameter (SD) and waist circumference (WC). RESULTS: Inter-reader reproducibility was excellent (relative difference: -0.34+/-0.52% for SAV and 0.59+/-0.93% for VAV, intra-class correlation (ICC)=0.99 each). The mean SAA/VAA ratio was significantly different from the mean SAV/VAV ratio (2.0+/-1.2 vs 1.7+/-0.9; P<0.001). The ratio of SAV/VAV was only weakly inversely associated with SD (ICC=-0.32, P=0.01) and not significantly associated with WC (ICC=-0.14, P=0.14) or body mass index (ICC=-0.17, P=0.09). The mean SAV/VAV ratio was significantly different between participants <60 vs >60 years (1.9+/-1.0 vs 1.5+/-0.7; P<0.001) and between men and women (1.2+/-0.5 vs 2.2+/-0.9; P<0.001). CONCLUSION: This study demonstrates that MDCT-based volumetric quantification of abdominal adipose tissue is highly reproducible. In addition, our results suggest that volumetric measurements can depict age- and gender-related differences of visceral and subcutaneous abdominal adipose tissue deposition. Further research is warranted to assess whether volumetric measurements may substantially improve the predictive value of obesity measures for insulin resistance, type 2 diabetes mellitus and other diseases. SN - 0307-0565 UR - https://www.unboundmedicine.com/medline/citation/16953256/Comparison_of_anthropometric_area__and_volume_based_assessment_of_abdominal_subcutaneous_and_visceral_adipose_tissue_volumes_using_multi_detector_computed_tomography_ L2 - https://doi.org/10.1038/sj.ijo.0803454 DB - PRIME DP - Unbound Medicine ER -