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Ischemia reperfusion injury and histamine release in isolated and perfused guinea-pig heart: pharmacological interventions.
Agents Actions. 1990 Apr; 30(1-2):198-201.AA

Abstract

Experiments were carried out to provide further information on the biochemical and morphological changes occurring in the guinea-pig heart after multiple ligature and reopening of the left anterior descending (LAD) coronary artery. In isolated perfused guinea-pig heart the reopening of LAD coronary artery leads to a release of histamine related to a loss of metachromasia by cardiac mast cells. The process is associated with malonyldialdehyde (MDA) production, cellular overload of calcium and ventricular arrhythmias which can be modulated by pharmacological interventions.

Authors+Show Affiliations

Department of Preclinical and Clinical Pharmacology, University of Florence, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1695442

Citation

Masini, E, et al. "Ischemia Reperfusion Injury and Histamine Release in Isolated and Perfused Guinea-pig Heart: Pharmacological Interventions." Agents and Actions, vol. 30, no. 1-2, 1990, pp. 198-201.
Masini E, Bianchi S, Gambassi F, et al. Ischemia reperfusion injury and histamine release in isolated and perfused guinea-pig heart: pharmacological interventions. Agents Actions. 1990;30(1-2):198-201.
Masini, E., Bianchi, S., Gambassi, F., Palmerani, B., Pistelli, A., Carlomagno, L., & Mannaioni, P. F. (1990). Ischemia reperfusion injury and histamine release in isolated and perfused guinea-pig heart: pharmacological interventions. Agents and Actions, 30(1-2), 198-201.
Masini E, et al. Ischemia Reperfusion Injury and Histamine Release in Isolated and Perfused Guinea-pig Heart: Pharmacological Interventions. Agents Actions. 1990;30(1-2):198-201. PubMed PMID: 1695442.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ischemia reperfusion injury and histamine release in isolated and perfused guinea-pig heart: pharmacological interventions. AU - Masini,E, AU - Bianchi,S, AU - Gambassi,F, AU - Palmerani,B, AU - Pistelli,A, AU - Carlomagno,L, AU - Mannaioni,P F, PY - 1990/4/1/pubmed PY - 1990/4/1/medline PY - 1990/4/1/entrez SP - 198 EP - 201 JF - Agents and actions JO - Agents Actions VL - 30 IS - 1-2 N2 - Experiments were carried out to provide further information on the biochemical and morphological changes occurring in the guinea-pig heart after multiple ligature and reopening of the left anterior descending (LAD) coronary artery. In isolated perfused guinea-pig heart the reopening of LAD coronary artery leads to a release of histamine related to a loss of metachromasia by cardiac mast cells. The process is associated with malonyldialdehyde (MDA) production, cellular overload of calcium and ventricular arrhythmias which can be modulated by pharmacological interventions. SN - 0065-4299 UR - https://www.unboundmedicine.com/medline/citation/1695442/Ischemia_reperfusion_injury_and_histamine_release_in_isolated_and_perfused_guinea_pig_heart:_pharmacological_interventions_ DB - PRIME DP - Unbound Medicine ER -