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On mast-cell-mediated angiogenesis in the rat mesenteric-window assay.
Agents Actions. 1990 Apr; 30(1-2):231-3.AA

Abstract

Testosterone propionate injected s.c. significantly reduced the mast-cell mediated angiogenic response occurring in prepubescent rats, thereby indicating that this angiogenic reaction can be influenced by hormonal stimuli. Since the newly-formed vessels are very small, one could expect that microscopic examination would be needed to quantify the vasculature. When studying the discernment of vessels at optical magnifications of between x 100 and x 1000 in sections of methacrylate-embedded mesenteric window, we found that the number of discernible vessels increased dramatically as the magnification increased. This not only underlines the genuine microvascular character of the reaction but also demonstrates the need for high-power magnification when truly quantifying an angiogenic reaction by optical means.

Authors+Show Affiliations

Norrby K
Department of Pathology, Gothenburg University, Sahlgren's Hospital, Sweden.
Jakobsson A
No affiliation info available
Sörbo J
No affiliation info available

MeSH

AnimalsMaleMast CellsMesenteryNeovascularization, PathologicRatsRats, Inbred StrainsTestosteronep-Methoxy-N-methylphenethylamine

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1695445

Citation

Norrby, K, et al. "On Mast-cell-mediated Angiogenesis in the Rat Mesenteric-window Assay." Agents and Actions, vol. 30, no. 1-2, 1990, pp. 231-3.
Norrby K, Jakobsson A, Sörbo J. On mast-cell-mediated angiogenesis in the rat mesenteric-window assay. Agents Actions. 1990;30(1-2):231-3.
Norrby, K., Jakobsson, A., & Sörbo, J. (1990). On mast-cell-mediated angiogenesis in the rat mesenteric-window assay. Agents and Actions, 30(1-2), 231-3.
Norrby K, Jakobsson A, Sörbo J. On Mast-cell-mediated Angiogenesis in the Rat Mesenteric-window Assay. Agents Actions. 1990;30(1-2):231-3. PubMed PMID: 1695445.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - On mast-cell-mediated angiogenesis in the rat mesenteric-window assay. AU - Norrby,K, AU - Jakobsson,A, AU - Sörbo,J, PY - 1990/4/1/pubmed PY - 1990/4/1/medline PY - 1990/4/1/entrez SP - 231 EP - 3 JF - Agents and actions JO - Agents Actions VL - 30 IS - 1-2 N2 - Testosterone propionate injected s.c. significantly reduced the mast-cell mediated angiogenic response occurring in prepubescent rats, thereby indicating that this angiogenic reaction can be influenced by hormonal stimuli. Since the newly-formed vessels are very small, one could expect that microscopic examination would be needed to quantify the vasculature. When studying the discernment of vessels at optical magnifications of between x 100 and x 1000 in sections of methacrylate-embedded mesenteric window, we found that the number of discernible vessels increased dramatically as the magnification increased. This not only underlines the genuine microvascular character of the reaction but also demonstrates the need for high-power magnification when truly quantifying an angiogenic reaction by optical means. SN - 0065-4299 UR - https://www.unboundmedicine.com/medline/citation/1695445/On_mast_cell_mediated_angiogenesis_in_the_rat_mesenteric_window_assay_ DB - PRIME DP - Unbound Medicine ER -