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Drug prescription in mild cognitive impairment: the physicians' perspective in Italy.
Int J Geriatr Psychiatry. 2006 Nov; 21(11):1071-7.IJ

Abstract

OBJECTIVES

Today there are no data on the type of drugs prescribed to MCI patients nor the prevalence of their prescription. The aim of this study was to describe which drugs were prescribed in 2004 for cognitive and non cognitive disturbances of patients with MCI in a sizable group of Italian expert centers for the diagnosis and treatment of Alzheimer's disease.

METHODS

Eighty-eight of the 314 contacted UVAs (28%) agreed to take part to the present study. The physicians were surveyed with a structured questionnaire assessing questions related to prescription of drug therapy based on their subjective judgement.

RESULTS

Cholinesterase inhibitors are prescribed to 90% of patients with AD but, interestingly, to about one in four patients with MCI (27%). Gingko and nootropics are prescribed infrequently, but in MCI two to three times more often than in AD. About one in four (27%) and one in ten (9%) MCI patient are prescribed SSRIs and benzodiazepines, a proportion similar to that of AD (28% and 10%), while atypical and traditional neuroleptics are virtually never used in MCI patients. Vitamin E is prescribed to more than half of MCI (57%) and in about half as many AD patients (27%).

CONCLUSIONS

These data suggest that lacking approved or clearly effective drugs for cognitive symptoms, physicians respond with 'analogy treatments' and by increasing the prescription of 'accessory drugs'. Non cognitive symptoms in MCI are managed virtually exclusively with SSRIs and benzodiazepines.

Authors+Show Affiliations

Laboratory of Epidemiology Neuroimaging & Telemedicine, IRCCS San Giovanni di Dio-FBF, Brescia, Italy. papers@centroAlzheimer.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16955446

Citation

Frisoni, Giovanni B., et al. "Drug Prescription in Mild Cognitive Impairment: the Physicians' Perspective in Italy." International Journal of Geriatric Psychiatry, vol. 21, no. 11, 2006, pp. 1071-7.
Frisoni GB, Canu E, Geroldi C, et al. Drug prescription in mild cognitive impairment: the physicians' perspective in Italy. Int J Geriatr Psychiatry. 2006;21(11):1071-7.
Frisoni, G. B., Canu, E., Geroldi, C., Zanetti, O., & Zacchi, V. (2006). Drug prescription in mild cognitive impairment: the physicians' perspective in Italy. International Journal of Geriatric Psychiatry, 21(11), 1071-7.
Frisoni GB, et al. Drug Prescription in Mild Cognitive Impairment: the Physicians' Perspective in Italy. Int J Geriatr Psychiatry. 2006;21(11):1071-7. PubMed PMID: 16955446.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Drug prescription in mild cognitive impairment: the physicians' perspective in Italy. AU - Frisoni,Giovanni B, AU - Canu,Elisa, AU - Geroldi,Cristina, AU - Zanetti,Orazio, AU - Zacchi,Valeria, PY - 2006/9/7/pubmed PY - 2007/9/22/medline PY - 2006/9/7/entrez SP - 1071 EP - 7 JF - International journal of geriatric psychiatry JO - Int J Geriatr Psychiatry VL - 21 IS - 11 N2 - OBJECTIVES: Today there are no data on the type of drugs prescribed to MCI patients nor the prevalence of their prescription. The aim of this study was to describe which drugs were prescribed in 2004 for cognitive and non cognitive disturbances of patients with MCI in a sizable group of Italian expert centers for the diagnosis and treatment of Alzheimer's disease. METHODS: Eighty-eight of the 314 contacted UVAs (28%) agreed to take part to the present study. The physicians were surveyed with a structured questionnaire assessing questions related to prescription of drug therapy based on their subjective judgement. RESULTS: Cholinesterase inhibitors are prescribed to 90% of patients with AD but, interestingly, to about one in four patients with MCI (27%). Gingko and nootropics are prescribed infrequently, but in MCI two to three times more often than in AD. About one in four (27%) and one in ten (9%) MCI patient are prescribed SSRIs and benzodiazepines, a proportion similar to that of AD (28% and 10%), while atypical and traditional neuroleptics are virtually never used in MCI patients. Vitamin E is prescribed to more than half of MCI (57%) and in about half as many AD patients (27%). CONCLUSIONS: These data suggest that lacking approved or clearly effective drugs for cognitive symptoms, physicians respond with 'analogy treatments' and by increasing the prescription of 'accessory drugs'. Non cognitive symptoms in MCI are managed virtually exclusively with SSRIs and benzodiazepines. SN - 0885-6230 UR - https://www.unboundmedicine.com/medline/citation/16955446/Drug_prescription_in_mild_cognitive_impairment:_the_physicians'_perspective_in_Italy_ L2 - https://doi.org/10.1002/gps.1609 DB - PRIME DP - Unbound Medicine ER -