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Outbreak detection and secondary prevention of Legionnaires' disease: a national approach.
Int J Hyg Environ Health. 2007 Jan; 210(1):1-7.IJ

Abstract

BACKGROUND

To stop a possible outbreak of Legionnaires' disease (LD) at an early stage an outbreak detection programme was installed in The Netherlands.

METHODS

The programme consisted of sampling and controlling of potential sources to which LD patients had been exposed during their incubation period. Potential sources were considered to be true sources of infection if two or more LD patients (cluster) had visited them, or if available patients' isolates and environmental Legionella spp. were indistinguishable by amplified fragment length polymorphism genotyping.

RESULTS

Rapid sampling and genotyping as well as cluster recognition helped to target control measures. Despite these measures, two small outbreaks were only stopped after renewal of the water system. The combination of genotyping and cluster recognition lead to 29 of 190 (15%) patient-source associations.

CONCLUSION

Systematic sampling and cluster recognition can contribute to outbreak detection and lead to cost-effective secondary prevention of Legionnaires' disease.

Links

Publisher Full Text

Authors+Show Affiliations

Den Boer JW
Municipal Health Service Kennemerland, P.O. Box 5514, 2000 GM Haarlem, The Netherlands. jwdenboer@hdk.nl
Verhoef L
No affiliation info available
Bencini MA
No affiliation info available
Bruin JP
No affiliation info available
Jansen R
No affiliation info available
Yzerman EP
No affiliation info available

MeSH

AdolescentAdultAgedAged, 80 and overChildChild, PreschoolDisease OutbreaksFemaleHumansLegionella pneumophilaLegionnaires' DiseaseMaleMiddle AgedNetherlandsWater MicrobiologyWater Supply

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16956792

Citation

Den Boer, Jeroen W., et al. "Outbreak Detection and Secondary Prevention of Legionnaires' Disease: a National Approach." International Journal of Hygiene and Environmental Health, vol. 210, no. 1, 2007, pp. 1-7.
Den Boer JW, Verhoef L, Bencini MA, et al. Outbreak detection and secondary prevention of Legionnaires' disease: a national approach. Int J Hyg Environ Health. 2007;210(1):1-7.
Den Boer, J. W., Verhoef, L., Bencini, M. A., Bruin, J. P., Jansen, R., & Yzerman, E. P. (2007). Outbreak detection and secondary prevention of Legionnaires' disease: a national approach. International Journal of Hygiene and Environmental Health, 210(1), 1-7.
Den Boer JW, et al. Outbreak Detection and Secondary Prevention of Legionnaires' Disease: a National Approach. Int J Hyg Environ Health. 2007;210(1):1-7. PubMed PMID: 16956792.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Outbreak detection and secondary prevention of Legionnaires' disease: a national approach. AU - Den Boer,Jeroen W, AU - Verhoef,Linda, AU - Bencini,Max A, AU - Bruin,Jacob P, AU - Jansen,R, AU - Yzerman,Ed P F, Y1 - 2006/09/07/ PY - 2006/01/23/received PY - 2006/07/03/revised PY - 2006/07/03/accepted PY - 2006/9/8/pubmed PY - 2007/4/6/medline PY - 2006/9/8/entrez SP - 1 EP - 7 JF - International journal of hygiene and environmental health JO - Int J Hyg Environ Health VL - 210 IS - 1 N2 - BACKGROUND: To stop a possible outbreak of Legionnaires' disease (LD) at an early stage an outbreak detection programme was installed in The Netherlands. METHODS: The programme consisted of sampling and controlling of potential sources to which LD patients had been exposed during their incubation period. Potential sources were considered to be true sources of infection if two or more LD patients (cluster) had visited them, or if available patients' isolates and environmental Legionella spp. were indistinguishable by amplified fragment length polymorphism genotyping. RESULTS: Rapid sampling and genotyping as well as cluster recognition helped to target control measures. Despite these measures, two small outbreaks were only stopped after renewal of the water system. The combination of genotyping and cluster recognition lead to 29 of 190 (15%) patient-source associations. CONCLUSION: Systematic sampling and cluster recognition can contribute to outbreak detection and lead to cost-effective secondary prevention of Legionnaires' disease. SN - 1438-4639 UR - https://www.unboundmedicine.com/medline/citation/16956792/Outbreak_detection_and_secondary_prevention_of_Legionnaires'_disease:_a_national_approach_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1438-4639(06)00073-3 DB - PRIME DP - Unbound Medicine ER -