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Fasting and post-prandial glycemia and their correlation with glycated hemoglobin in Type 2 diabetes.
J Endocrinol Invest. 2006 Jul-Aug; 29(7):619-24.JE

Abstract

OBJECTIVE

The relative contribution of fasting and post-prandial glucose to glycated hemoglobin (HbA1c) is controversial. In the present study, we assessed the relationship with HbA1c of fasting and post-prandial glucose measured in a more naturalistic setting, through home glucose self-monitoring or with a continuous glucose monitoring system (CGM).

MATERIALS AND METHODS

A consecutive series of 300 patients with Type 2 diabetes were enrolled in the study, provided that they performed blood glucose self-monitoring. HbA1c and fasting plasma glucose (FPG) were measured at enrolment.

RESULTS

Both fasting plasma and capillary glucose showed a significant correlation with HbA1c (r=0.66 and 0.61, respectively; p<0.001). When home glucose monitoring was considered, both mean fasting and post-prandial glucose showed a significant correlation with HbA1c (r=0.71 and 0.73, respectively). In patients in the lower tertile of body mass index (BMI), HbA1c showed a significant correlation at multivariate analysis with post-prandial glucose, but not with fasting glucose. In patients with HbA1c >7%, both fasting and post-prandial glucose showed a significant correlation, after adjustment for age and BMI, with HbA1c (both p<0.01); conversely, in those with HbA1c < or =7%, such a correlation could be observed for fasting (p<0.01), but not for post-prandial glucose.

CONCLUSION

In conclusion, both fasting and post-prandial glucose contribute to the determination of HbA1c . Home glucose self-monitoring appears to provide a more accurate assessment of metabolic control than a single plasma glucose measurement in experimental conditions. Fasting glucose could provide a greater contribution to HbA1c in patients with lower HbA1c, while post-prandial glucose seems to play a major role in leaner Type 2 diabetic subjects.

Authors+Show Affiliations

Monami M
Geriatric Unit, Department of Critical Care, University of Florence Medical School, 50141 Florence, Italy. mmonami@libero.it
Lamanna C
No affiliation info available
Lambertucci L
No affiliation info available
Longo R
No affiliation info available
Cocca C
No affiliation info available
Addante F
No affiliation info available
Lotti E
No affiliation info available
Masotti G
No affiliation info available
Marchionni N
No affiliation info available
Mannucci E
No affiliation info available

MeSH

AgedBlood GlucoseBlood Glucose Self-MonitoringBlood PressureBody Mass IndexCholesterolDiabetes Mellitus, Type 2FastingFemaleGlycated Hemoglobin AHumansMaleMiddle AgedPostprandial PeriodStatistics as Topic

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16957410

Citation

Monami, M, et al. "Fasting and Post-prandial Glycemia and Their Correlation With Glycated Hemoglobin in Type 2 Diabetes." Journal of Endocrinological Investigation, vol. 29, no. 7, 2006, pp. 619-24.
Monami M, Lamanna C, Lambertucci L, et al. Fasting and post-prandial glycemia and their correlation with glycated hemoglobin in Type 2 diabetes. J Endocrinol Invest. 2006;29(7):619-24.
Monami, M., Lamanna, C., Lambertucci, L., Longo, R., Cocca, C., Addante, F., Lotti, E., Masotti, G., Marchionni, N., & Mannucci, E. (2006). Fasting and post-prandial glycemia and their correlation with glycated hemoglobin in Type 2 diabetes. Journal of Endocrinological Investigation, 29(7), 619-24.
Monami M, et al. Fasting and Post-prandial Glycemia and Their Correlation With Glycated Hemoglobin in Type 2 Diabetes. J Endocrinol Invest. 2006 Jul-Aug;29(7):619-24. PubMed PMID: 16957410.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fasting and post-prandial glycemia and their correlation with glycated hemoglobin in Type 2 diabetes. AU - Monami,M, AU - Lamanna,C, AU - Lambertucci,L, AU - Longo,R, AU - Cocca,C, AU - Addante,F, AU - Lotti,E, AU - Masotti,G, AU - Marchionni,N, AU - Mannucci,E, PY - 2006/9/8/pubmed PY - 2006/10/21/medline PY - 2006/9/8/entrez SP - 619 EP - 24 JF - Journal of endocrinological investigation JO - J Endocrinol Invest VL - 29 IS - 7 N2 - OBJECTIVE: The relative contribution of fasting and post-prandial glucose to glycated hemoglobin (HbA1c) is controversial. In the present study, we assessed the relationship with HbA1c of fasting and post-prandial glucose measured in a more naturalistic setting, through home glucose self-monitoring or with a continuous glucose monitoring system (CGM). MATERIALS AND METHODS: A consecutive series of 300 patients with Type 2 diabetes were enrolled in the study, provided that they performed blood glucose self-monitoring. HbA1c and fasting plasma glucose (FPG) were measured at enrolment. RESULTS: Both fasting plasma and capillary glucose showed a significant correlation with HbA1c (r=0.66 and 0.61, respectively; p<0.001). When home glucose monitoring was considered, both mean fasting and post-prandial glucose showed a significant correlation with HbA1c (r=0.71 and 0.73, respectively). In patients in the lower tertile of body mass index (BMI), HbA1c showed a significant correlation at multivariate analysis with post-prandial glucose, but not with fasting glucose. In patients with HbA1c >7%, both fasting and post-prandial glucose showed a significant correlation, after adjustment for age and BMI, with HbA1c (both p<0.01); conversely, in those with HbA1c < or =7%, such a correlation could be observed for fasting (p<0.01), but not for post-prandial glucose. CONCLUSION: In conclusion, both fasting and post-prandial glucose contribute to the determination of HbA1c . Home glucose self-monitoring appears to provide a more accurate assessment of metabolic control than a single plasma glucose measurement in experimental conditions. Fasting glucose could provide a greater contribution to HbA1c in patients with lower HbA1c, while post-prandial glucose seems to play a major role in leaner Type 2 diabetic subjects. SN - 0391-4097 UR - https://www.unboundmedicine.com/medline/citation/16957410/Fasting_and_post_prandial_glycemia_and_their_correlation_with_glycated_hemoglobin_in_Type_2_diabetes_ DB - PRIME DP - Unbound Medicine ER -