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Pulse wave velocity is increased in patients with transient myocardial ischemia.
J Hypertens. 2006 Oct; 24(10):2085-90.JH

Abstract

OBJECTIVE

We have recently shown that mean pulse pressure is higher in patients with transient myocardial ischemia. Pulse pressure elevation might be an important consequence of increased arterial stiffness. The aim of this study was to prove if arterial stiffness is changed in patients with transient myocardial ischemia who bear a high cardiovascular risk. Additionally we investigated whether arterial stiffness or wave reflection is the best indicator for transient myocardial ischemia. Aortic pulse wave velocity (PWV) is a measure of arterial stiffness, and augmentation index (AIx) an indication of arterial wave reflection. Both are indicators for cardiovascular risk.

METHODS

PWV (carotid-femoral) and AIx (SphygmoCor) were assessed in 74 hypertensive patients. Transient myocardial ischemia was detected using an ST-triggered 24-h ambulatory blood pressure monitoring device.

RESULTS

ST-segment depressions were recorded in 30 of 74 patients. There were no significant differences with regard to age, mean arterial pressure, systolic blood pressure, diastolic blood pressure or heart rate. PWV was seen to be higher in patients with transient myocardial ischemia (10.6 versus 9.5 m/s, P = 0.036). There was no significant difference in AIx between the two groups. PWV (r = 0.36, P = 0.002) but not AIx correlated with pulse pressure.

CONCLUSIONS

PWV is higher in hypertensive individuals (age > 60 years) with transient myocardial ischemia, suggesting that PWV is an indicator of increased cardiovascular risk. Although AIx is known to be associated with several cardiovascular diseases, it was not seen to be associated with silent myocardial ischemia. Our results suggest that the clinical significance of parameters of arterial stiffness and arterial wave reflection change with age, with a higher clinical importance of PWV indicated in patients over the age of 60.

Authors+Show Affiliations

Medizinische Poliklinik, University of Bonn, Germany bInstitute for Medical Statistics, University of Bonn, Germany. johannes.baulmann@ukb.uni-bonn.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16957570

Citation

Baulmann, Johannes, et al. "Pulse Wave Velocity Is Increased in Patients With Transient Myocardial Ischemia." Journal of Hypertension, vol. 24, no. 10, 2006, pp. 2085-90.
Baulmann J, Homsi R, Uen S, et al. Pulse wave velocity is increased in patients with transient myocardial ischemia. J Hypertens. 2006;24(10):2085-90.
Baulmann, J., Homsi, R., Uen, S., Düsing, R., Fimmers, R., Vetter, H., & Mengden, T. (2006). Pulse wave velocity is increased in patients with transient myocardial ischemia. Journal of Hypertension, 24(10), 2085-90.
Baulmann J, et al. Pulse Wave Velocity Is Increased in Patients With Transient Myocardial Ischemia. J Hypertens. 2006;24(10):2085-90. PubMed PMID: 16957570.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pulse wave velocity is increased in patients with transient myocardial ischemia. AU - Baulmann,Johannes, AU - Homsi,Rami, AU - Uen,Sakir, AU - Düsing,Rainer, AU - Fimmers,Rolf, AU - Vetter,Hans, AU - Mengden,Thomas, PY - 2006/9/8/pubmed PY - 2007/1/31/medline PY - 2006/9/8/entrez SP - 2085 EP - 90 JF - Journal of hypertension JO - J. Hypertens. VL - 24 IS - 10 N2 - OBJECTIVE: We have recently shown that mean pulse pressure is higher in patients with transient myocardial ischemia. Pulse pressure elevation might be an important consequence of increased arterial stiffness. The aim of this study was to prove if arterial stiffness is changed in patients with transient myocardial ischemia who bear a high cardiovascular risk. Additionally we investigated whether arterial stiffness or wave reflection is the best indicator for transient myocardial ischemia. Aortic pulse wave velocity (PWV) is a measure of arterial stiffness, and augmentation index (AIx) an indication of arterial wave reflection. Both are indicators for cardiovascular risk. METHODS: PWV (carotid-femoral) and AIx (SphygmoCor) were assessed in 74 hypertensive patients. Transient myocardial ischemia was detected using an ST-triggered 24-h ambulatory blood pressure monitoring device. RESULTS: ST-segment depressions were recorded in 30 of 74 patients. There were no significant differences with regard to age, mean arterial pressure, systolic blood pressure, diastolic blood pressure or heart rate. PWV was seen to be higher in patients with transient myocardial ischemia (10.6 versus 9.5 m/s, P = 0.036). There was no significant difference in AIx between the two groups. PWV (r = 0.36, P = 0.002) but not AIx correlated with pulse pressure. CONCLUSIONS: PWV is higher in hypertensive individuals (age > 60 years) with transient myocardial ischemia, suggesting that PWV is an indicator of increased cardiovascular risk. Although AIx is known to be associated with several cardiovascular diseases, it was not seen to be associated with silent myocardial ischemia. Our results suggest that the clinical significance of parameters of arterial stiffness and arterial wave reflection change with age, with a higher clinical importance of PWV indicated in patients over the age of 60. SN - 0263-6352 UR - https://www.unboundmedicine.com/medline/citation/16957570/Pulse_wave_velocity_is_increased_in_patients_with_transient_myocardial_ischemia_ L2 - http://dx.doi.org/10.1097/01.hjh.0000244959.92856.7e DB - PRIME DP - Unbound Medicine ER -