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Relationship between antihypertensive drug therapy and cognitive function in elderly hypertensive patients with memory complaints.
J Hypertens. 2006 Oct; 24(10):2101-7.JH

Abstract

OBJECTIVE

To evaluate the relationship between antihypertensive treatments and cognitive function in elderly hypertensive patients with memory complaints.

METHODS

The association between cognitive function and antihypertensive drug therapy was studied in 1241 hypertensive elderly patients with memory complaints attending a geriatric outpatient clinic. Cognitive function was assessed using the Mini Mental State Examination (MMSE) and validated neuropsychological tests (Cognitive Efficiency Profile; CEP). Patients were classified into four categories according to their cognitive status: normal cognitive function, mild cognitive impairment (MCI), Alzheimer's disease (AD) or vascular dementia (VaD).

RESULTS

In this population aged 78 +/- 8 years, with a mean blood pressure of 152 +/- 19/86 +/- 12 mmHg, antihypertensive treatment was prescribed for 57% of patients. After adjustment for age, sex and education, treated hypertensive patients had better cognitive function than untreated patients (MMSE score 23.9 +/- 5.6/30 versus 22.7 +/- 6.4/30, P < 0.001, CEP score 49.1 +/- 24.9/100 versus 45.4 +/- 23.7/100, P < 0.001). This association was observed independently of the cognitive status, both in normal, MCI, AD and VaD hypertensive patients. The odds ratio (OR) for AD was 0.58 [95% confidence interval (CI) 0.42-0.81] in treated compared with untreated hypertensive patients. In patients on antihypertensive therapy, higher cognitive function was observed in patients using calcium antagonists compared with those without calcium antagonists (CEP 52.9 +/- 24.6/100 versus 46.4 +/- 23.4/100, P < 0.001; OR for AD 0.67; 95% CI 0.45-0.99), independently of blood pressure level.

CONCLUSIONS

Antihypertensive therapy was associated with a lower risk of cognitive impairment and AD. In particular, the use of calcium antagonists was associated with a decreased risk of cognitive impairment and AD independently of the blood pressure level, suggesting a specific neuroprotective effect of these antihypertensive agents.

Authors+Show Affiliations

Université Paris-Descartes, Department of Geriatrics, Hôpital Broca, Paris, France. olivier.hanon@brc.ap-hop-paris.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16957572

Citation

Hanon, Olivier, et al. "Relationship Between Antihypertensive Drug Therapy and Cognitive Function in Elderly Hypertensive Patients With Memory Complaints." Journal of Hypertension, vol. 24, no. 10, 2006, pp. 2101-7.
Hanon O, Pequignot R, Seux ML, et al. Relationship between antihypertensive drug therapy and cognitive function in elderly hypertensive patients with memory complaints. J Hypertens. 2006;24(10):2101-7.
Hanon, O., Pequignot, R., Seux, M. L., Lenoir, H., Bune, A., Rigaud, A. S., Forette, F., & Girerd, X. (2006). Relationship between antihypertensive drug therapy and cognitive function in elderly hypertensive patients with memory complaints. Journal of Hypertension, 24(10), 2101-7.
Hanon O, et al. Relationship Between Antihypertensive Drug Therapy and Cognitive Function in Elderly Hypertensive Patients With Memory Complaints. J Hypertens. 2006;24(10):2101-7. PubMed PMID: 16957572.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between antihypertensive drug therapy and cognitive function in elderly hypertensive patients with memory complaints. AU - Hanon,Olivier, AU - Pequignot,Renaud, AU - Seux,Marie Laure, AU - Lenoir,Hermine, AU - Bune,Alexandra, AU - Rigaud,Anne Sophie, AU - Forette,Françoise, AU - Girerd,Xavier, PY - 2006/9/8/pubmed PY - 2007/1/31/medline PY - 2006/9/8/entrez SP - 2101 EP - 7 JF - Journal of hypertension JO - J. Hypertens. VL - 24 IS - 10 N2 - OBJECTIVE: To evaluate the relationship between antihypertensive treatments and cognitive function in elderly hypertensive patients with memory complaints. METHODS: The association between cognitive function and antihypertensive drug therapy was studied in 1241 hypertensive elderly patients with memory complaints attending a geriatric outpatient clinic. Cognitive function was assessed using the Mini Mental State Examination (MMSE) and validated neuropsychological tests (Cognitive Efficiency Profile; CEP). Patients were classified into four categories according to their cognitive status: normal cognitive function, mild cognitive impairment (MCI), Alzheimer's disease (AD) or vascular dementia (VaD). RESULTS: In this population aged 78 +/- 8 years, with a mean blood pressure of 152 +/- 19/86 +/- 12 mmHg, antihypertensive treatment was prescribed for 57% of patients. After adjustment for age, sex and education, treated hypertensive patients had better cognitive function than untreated patients (MMSE score 23.9 +/- 5.6/30 versus 22.7 +/- 6.4/30, P < 0.001, CEP score 49.1 +/- 24.9/100 versus 45.4 +/- 23.7/100, P < 0.001). This association was observed independently of the cognitive status, both in normal, MCI, AD and VaD hypertensive patients. The odds ratio (OR) for AD was 0.58 [95% confidence interval (CI) 0.42-0.81] in treated compared with untreated hypertensive patients. In patients on antihypertensive therapy, higher cognitive function was observed in patients using calcium antagonists compared with those without calcium antagonists (CEP 52.9 +/- 24.6/100 versus 46.4 +/- 23.4/100, P < 0.001; OR for AD 0.67; 95% CI 0.45-0.99), independently of blood pressure level. CONCLUSIONS: Antihypertensive therapy was associated with a lower risk of cognitive impairment and AD. In particular, the use of calcium antagonists was associated with a decreased risk of cognitive impairment and AD independently of the blood pressure level, suggesting a specific neuroprotective effect of these antihypertensive agents. SN - 0263-6352 UR - https://www.unboundmedicine.com/medline/citation/16957572/Relationship_between_antihypertensive_drug_therapy_and_cognitive_function_in_elderly_hypertensive_patients_with_memory_complaints_ L2 - http://dx.doi.org/10.1097/01.hjh.0000244961.69985.05 DB - PRIME DP - Unbound Medicine ER -