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Evidence for the roles of histamine and prostaglandins as mediators in exercise-induced asthma: the inhibitory effect of terfenadine and flurbiprofen alone and in combination.
Eur Respir J 1990; 3(5):540-7ER

Abstract

We investigated the effects of terfenadine, a histamine H1-receptor antagonist, and flurbiprofen, a cyclooxygenase inhibitor, on exercise-induced bronchoconstriction to assess the contribution of the mast cell products histamine and prostaglandins. Eight asthmatics were studied on 4 occasions with treadmill exercise tests. Terfenadine or placebo was administered 3 h prior to exercise, and flurbiprofen or placebo was administered 2 h prior to exercise, in a double-blind randomized trial. Airway calibre was determined by measurement of the forced expiratory volume in one second (FEV1) immediately prior to exercise challenge, and over 30 min post-exercise. Following placebo, the mean maximum percentage fall in FEV1 was 39%. This fell to 25% after terfenadine (p less than 0.05), 27% after flurbiprofen (p less than 0.05), and 30% after the active combination (NS). Analysis of the areas under curves of percentage falls in FEV1 over 30 min showed significant inhibition on all 3 active drug days (p less than 0.05). We conclude that histamine release and prostaglandin generation contribute to exercise-induced bronchoconstriction, although the interaction between these mediators appears complex.

Authors+Show Affiliations

Immunopharmacology Group, Southampton General Hospital, UK.No affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

1695877

Citation

Finnerty, J P., and S T. Holgate. "Evidence for the Roles of Histamine and Prostaglandins as Mediators in Exercise-induced Asthma: the Inhibitory Effect of Terfenadine and Flurbiprofen Alone and in Combination." The European Respiratory Journal, vol. 3, no. 5, 1990, pp. 540-7.
Finnerty JP, Holgate ST. Evidence for the roles of histamine and prostaglandins as mediators in exercise-induced asthma: the inhibitory effect of terfenadine and flurbiprofen alone and in combination. Eur Respir J. 1990;3(5):540-7.
Finnerty, J. P., & Holgate, S. T. (1990). Evidence for the roles of histamine and prostaglandins as mediators in exercise-induced asthma: the inhibitory effect of terfenadine and flurbiprofen alone and in combination. The European Respiratory Journal, 3(5), pp. 540-7.
Finnerty JP, Holgate ST. Evidence for the Roles of Histamine and Prostaglandins as Mediators in Exercise-induced Asthma: the Inhibitory Effect of Terfenadine and Flurbiprofen Alone and in Combination. Eur Respir J. 1990;3(5):540-7. PubMed PMID: 1695877.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence for the roles of histamine and prostaglandins as mediators in exercise-induced asthma: the inhibitory effect of terfenadine and flurbiprofen alone and in combination. AU - Finnerty,J P, AU - Holgate,S T, PY - 1990/5/1/pubmed PY - 1990/5/1/medline PY - 1990/5/1/entrez SP - 540 EP - 7 JF - The European respiratory journal JO - Eur. Respir. J. VL - 3 IS - 5 N2 - We investigated the effects of terfenadine, a histamine H1-receptor antagonist, and flurbiprofen, a cyclooxygenase inhibitor, on exercise-induced bronchoconstriction to assess the contribution of the mast cell products histamine and prostaglandins. Eight asthmatics were studied on 4 occasions with treadmill exercise tests. Terfenadine or placebo was administered 3 h prior to exercise, and flurbiprofen or placebo was administered 2 h prior to exercise, in a double-blind randomized trial. Airway calibre was determined by measurement of the forced expiratory volume in one second (FEV1) immediately prior to exercise challenge, and over 30 min post-exercise. Following placebo, the mean maximum percentage fall in FEV1 was 39%. This fell to 25% after terfenadine (p less than 0.05), 27% after flurbiprofen (p less than 0.05), and 30% after the active combination (NS). Analysis of the areas under curves of percentage falls in FEV1 over 30 min showed significant inhibition on all 3 active drug days (p less than 0.05). We conclude that histamine release and prostaglandin generation contribute to exercise-induced bronchoconstriction, although the interaction between these mediators appears complex. SN - 0903-1936 UR - https://www.unboundmedicine.com/medline/citation/1695877/Evidence_for_the_roles_of_histamine_and_prostaglandins_as_mediators_in_exercise_induced_asthma:_the_inhibitory_effect_of_terfenadine_and_flurbiprofen_alone_and_in_combination_ L2 - http://www.diseaseinfosearch.org/result/633 DB - PRIME DP - Unbound Medicine ER -