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Floating hot-melt extruded tablets for gastroretentive controlled drug release system.
J Control Release. 2006 Oct 10; 115(2):121-9.JC

Abstract

The purpose of this study was to investigate the influence of sodium bicarbonate on the physicochemical properties of controlled release hot-melt extruded (HME) tablets containing Eudragit RS PO and/or Eudragit E PO. Acetohydroxamic acid and chlorpheniramine maleate were used as model drugs. Sodium bicarbonate was incorporated into the tablet formulations and the drug release properties and buoyancy in media for HME tablets and directly compressed (DC) tablets were investigated. The HME tablets prepared from the powder blend containing both Eudragit RS PO and sodium bicarbonate exhibited sustained release properties and the tablets floated on the surface of the media for 24 h. The cross-sectional morphology of the HME tablets showed a porous structure since CO(2) gas was generated due to the thermal decomposition of sodium bicarbonate in the softened acrylic polymers at elevated temperature during the extrusion process. In contrast, all DC tablets prepared in this study showed no buoyancy and rapid drug release in the dissolution media. The drug release rate from floating HME tablets was controlled by both the incorporation of Eudragit E PO into the matrix tablet and the diameter of the die used in the extrusion equipment. The drug release profiles and buoyancy of the floating HME tablets were stable when stored at 40 degrees C/75%RH for 3 months.

Authors+Show Affiliations

Division of Pharmaceutics, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA. mamoru.fukuda@mb.kyorin-pharm.co.jp <mamoru.fukuda@mb.kyorin-pharm.co.jp>No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16959356

Citation

Fukuda, Mamoru, et al. "Floating Hot-melt Extruded Tablets for Gastroretentive Controlled Drug Release System." Journal of Controlled Release : Official Journal of the Controlled Release Society, vol. 115, no. 2, 2006, pp. 121-9.
Fukuda M, Peppas NA, McGinity JW. Floating hot-melt extruded tablets for gastroretentive controlled drug release system. J Control Release. 2006;115(2):121-9.
Fukuda, M., Peppas, N. A., & McGinity, J. W. (2006). Floating hot-melt extruded tablets for gastroretentive controlled drug release system. Journal of Controlled Release : Official Journal of the Controlled Release Society, 115(2), 121-9.
Fukuda M, Peppas NA, McGinity JW. Floating Hot-melt Extruded Tablets for Gastroretentive Controlled Drug Release System. J Control Release. 2006 Oct 10;115(2):121-9. PubMed PMID: 16959356.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Floating hot-melt extruded tablets for gastroretentive controlled drug release system. AU - Fukuda,Mamoru, AU - Peppas,Nicholas A, AU - McGinity,James W, Y1 - 2006/07/21/ PY - 2006/02/21/received PY - 2006/07/13/revised PY - 2006/07/15/accepted PY - 2006/9/9/pubmed PY - 2007/1/4/medline PY - 2006/9/9/entrez SP - 121 EP - 9 JF - Journal of controlled release : official journal of the Controlled Release Society JO - J Control Release VL - 115 IS - 2 N2 - The purpose of this study was to investigate the influence of sodium bicarbonate on the physicochemical properties of controlled release hot-melt extruded (HME) tablets containing Eudragit RS PO and/or Eudragit E PO. Acetohydroxamic acid and chlorpheniramine maleate were used as model drugs. Sodium bicarbonate was incorporated into the tablet formulations and the drug release properties and buoyancy in media for HME tablets and directly compressed (DC) tablets were investigated. The HME tablets prepared from the powder blend containing both Eudragit RS PO and sodium bicarbonate exhibited sustained release properties and the tablets floated on the surface of the media for 24 h. The cross-sectional morphology of the HME tablets showed a porous structure since CO(2) gas was generated due to the thermal decomposition of sodium bicarbonate in the softened acrylic polymers at elevated temperature during the extrusion process. In contrast, all DC tablets prepared in this study showed no buoyancy and rapid drug release in the dissolution media. The drug release rate from floating HME tablets was controlled by both the incorporation of Eudragit E PO into the matrix tablet and the diameter of the die used in the extrusion equipment. The drug release profiles and buoyancy of the floating HME tablets were stable when stored at 40 degrees C/75%RH for 3 months. SN - 0168-3659 UR - https://www.unboundmedicine.com/medline/citation/16959356/Floating_hot_melt_extruded_tablets_for_gastroretentive_controlled_drug_release_system_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-3659(06)00365-8 DB - PRIME DP - Unbound Medicine ER -