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Exercise-induced systemic effects in muscle-wasted patients with COPD.
Med Sci Sports Exerc 2006; 38(9):1543-52MS

Abstract

PURPOSE

Physical exercise is known to induce an acute inflammatory response and oxidative stress in healthy subjects and patients with chronic obstructive pulmonary disease (COPD). Increasing evidence associates systemic inflammation and oxidative stress with muscle wasting and muscle dysfunction in COPD. In the present study, it was hypothesized that exercise-induced systemic inflammatory and oxidative responses in muscle-wasted COPD patients are increased compared with non-muscle-wasted patients and healthy subjects.

METHODS

Pulmonary function, body composition, and quadriceps muscle strength were measured in 10 muscle-wasted (fat-free mass index (FFMI) < 16 kg x m(-2) (men), < 15 kg x m(-2) (women)), 10 non-muscle-wasted COPD patients, and 10 healthy subjects. Systemic inflammation (C-reactive protein (CRP), leukocytes, cytokines) and oxidative stress (production of reactive oxygen species (ROS) by neutrophils, plasma antioxidant capacity, protein oxidation, lipid peroxidation, oxidized to reduced glutathione ratio (GSSG/GSH)) were determined before and after maximal and submaximal (50% of maximal work rate) cycle ergometry.

RESULTS

Low-grade systemic inflammation was significantly (P < 0.05) elevated in all COPD patients and tended to be highest in muscle-wasted patients. A decreased antioxidant status (plasma antioxidant capacity, P < 0.05; GSH, P < 0.05) and increased protein oxidation (P < 0.001) reflected increased basal oxidative stress in muscle-wasted COPD patients compared with both other groups. Both maximal and submaximal exercise caused increased inflammatory (IL-6, +1.1 pg. x mL(-1) vs rest, P < 0.05) and oxidative responses (ROS release by neutrophils, + 32%; GSSG/GSH + 29%; lipid peroxidation, + 30% vs rest) in muscle-wasted COPD patients, which were less pronounced or not observed in non-muscle-wasted patients and healthy subjects.

CONCLUSIONS

These data indicate that both maximal and submaximal exercise induce increased systemic inflammatory and oxidative responses in muscle-wasted COPD patients compared with non-muscle-wasted patients and healthy subjects.

Authors+Show Affiliations

Department of Pulmonary Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. H.vanHelvoort@long.umcn.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16960513

Citation

Van Helvoort, Hanneke A C., et al. "Exercise-induced Systemic Effects in Muscle-wasted Patients With COPD." Medicine and Science in Sports and Exercise, vol. 38, no. 9, 2006, pp. 1543-52.
Van Helvoort HA, Heijdra YF, Thijs HM, et al. Exercise-induced systemic effects in muscle-wasted patients with COPD. Med Sci Sports Exerc. 2006;38(9):1543-52.
Van Helvoort, H. A., Heijdra, Y. F., Thijs, H. M., Viña, J., Wanten, G. J., & Dekhuijzen, P. N. (2006). Exercise-induced systemic effects in muscle-wasted patients with COPD. Medicine and Science in Sports and Exercise, 38(9), pp. 1543-52.
Van Helvoort HA, et al. Exercise-induced Systemic Effects in Muscle-wasted Patients With COPD. Med Sci Sports Exerc. 2006;38(9):1543-52. PubMed PMID: 16960513.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exercise-induced systemic effects in muscle-wasted patients with COPD. AU - Van Helvoort,Hanneke A C, AU - Heijdra,Yvonne F, AU - Thijs,Hub M H, AU - Viña,José, AU - Wanten,Geert J A, AU - Dekhuijzen,P N Richard, PY - 2006/9/9/pubmed PY - 2006/12/13/medline PY - 2006/9/9/entrez SP - 1543 EP - 52 JF - Medicine and science in sports and exercise JO - Med Sci Sports Exerc VL - 38 IS - 9 N2 - PURPOSE: Physical exercise is known to induce an acute inflammatory response and oxidative stress in healthy subjects and patients with chronic obstructive pulmonary disease (COPD). Increasing evidence associates systemic inflammation and oxidative stress with muscle wasting and muscle dysfunction in COPD. In the present study, it was hypothesized that exercise-induced systemic inflammatory and oxidative responses in muscle-wasted COPD patients are increased compared with non-muscle-wasted patients and healthy subjects. METHODS: Pulmonary function, body composition, and quadriceps muscle strength were measured in 10 muscle-wasted (fat-free mass index (FFMI) < 16 kg x m(-2) (men), < 15 kg x m(-2) (women)), 10 non-muscle-wasted COPD patients, and 10 healthy subjects. Systemic inflammation (C-reactive protein (CRP), leukocytes, cytokines) and oxidative stress (production of reactive oxygen species (ROS) by neutrophils, plasma antioxidant capacity, protein oxidation, lipid peroxidation, oxidized to reduced glutathione ratio (GSSG/GSH)) were determined before and after maximal and submaximal (50% of maximal work rate) cycle ergometry. RESULTS: Low-grade systemic inflammation was significantly (P < 0.05) elevated in all COPD patients and tended to be highest in muscle-wasted patients. A decreased antioxidant status (plasma antioxidant capacity, P < 0.05; GSH, P < 0.05) and increased protein oxidation (P < 0.001) reflected increased basal oxidative stress in muscle-wasted COPD patients compared with both other groups. Both maximal and submaximal exercise caused increased inflammatory (IL-6, +1.1 pg. x mL(-1) vs rest, P < 0.05) and oxidative responses (ROS release by neutrophils, + 32%; GSSG/GSH + 29%; lipid peroxidation, + 30% vs rest) in muscle-wasted COPD patients, which were less pronounced or not observed in non-muscle-wasted patients and healthy subjects. CONCLUSIONS: These data indicate that both maximal and submaximal exercise induce increased systemic inflammatory and oxidative responses in muscle-wasted COPD patients compared with non-muscle-wasted patients and healthy subjects. SN - 0195-9131 UR - https://www.unboundmedicine.com/medline/citation/16960513/Exercise_induced_systemic_effects_in_muscle_wasted_patients_with_COPD_ L2 - http://Insights.ovid.com/pubmed?pmid=16960513 DB - PRIME DP - Unbound Medicine ER -