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Environmental determinants of Parkinson's disease.
Arch Environ Occup Health 2005 Jan-Feb; 60(1):32-8AE

Abstract

Increasing toxicologic and epidemiologic evidence suggests that pesticides and other environmental exposures are associated with idiopathic Parkinson's disease. Using a case-control study, the authors examined the impact of farming, pesticide use, rural residence, and well water use (including critical periods of childhood exposure) on the risk of Parkinson's disease. After adjustment for confounding, > or = 40 years of well-water exposure (compared to no well water use) was associated with an increased risk of Parkinson's disease (OR = 7.1; 95% CI: 2.3-22.1). The authors found an increased risk of Parkinson's disease (OR = 2.1; 95% Cl: 0.7-6.4) for well water use during the first 20 years of life (compared with <20 years of exposure) and saw some suggestion of an exposure-response relationship with increasing childhood exposure. Farming and pesticide use (occupational or residential) was not associated with Parkinson's disease but exposure assessment limitations warrant further investigation.

Authors+Show Affiliations

Program in Environmental Studies, Southern Illinois University, Edwardsville, IL, USA. wright.michael@epa.govNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16961006

Citation

Wright, J Michael, and Jane Keller-Byrne. "Environmental Determinants of Parkinson's Disease." Archives of Environmental & Occupational Health, vol. 60, no. 1, 2005, pp. 32-8.
Wright JM, Keller-Byrne J. Environmental determinants of Parkinson's disease. Arch Environ Occup Health. 2005;60(1):32-8.
Wright, J. M., & Keller-Byrne, J. (2005). Environmental determinants of Parkinson's disease. Archives of Environmental & Occupational Health, 60(1), pp. 32-8.
Wright JM, Keller-Byrne J. Environmental Determinants of Parkinson's Disease. Arch Environ Occup Health. 2005;60(1):32-8. PubMed PMID: 16961006.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Environmental determinants of Parkinson's disease. AU - Wright,J Michael, AU - Keller-Byrne,Jane, PY - 2006/9/12/pubmed PY - 2006/9/29/medline PY - 2006/9/12/entrez SP - 32 EP - 8 JF - Archives of environmental & occupational health JO - Arch Environ Occup Health VL - 60 IS - 1 N2 - Increasing toxicologic and epidemiologic evidence suggests that pesticides and other environmental exposures are associated with idiopathic Parkinson's disease. Using a case-control study, the authors examined the impact of farming, pesticide use, rural residence, and well water use (including critical periods of childhood exposure) on the risk of Parkinson's disease. After adjustment for confounding, > or = 40 years of well-water exposure (compared to no well water use) was associated with an increased risk of Parkinson's disease (OR = 7.1; 95% CI: 2.3-22.1). The authors found an increased risk of Parkinson's disease (OR = 2.1; 95% Cl: 0.7-6.4) for well water use during the first 20 years of life (compared with <20 years of exposure) and saw some suggestion of an exposure-response relationship with increasing childhood exposure. Farming and pesticide use (occupational or residential) was not associated with Parkinson's disease but exposure assessment limitations warrant further investigation. SN - 1933-8244 UR - https://www.unboundmedicine.com/medline/citation/16961006/Environmental_determinants_of_Parkinson's_disease_ L2 - http://www.tandfonline.com/doi/full/10.3200/AEOH.60.1.32-38 DB - PRIME DP - Unbound Medicine ER -