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Gabapentin versus nortriptyline in post-herpetic neuralgia patients: a randomized, double-blind clinical trial--the GONIP Trial.
Int J Clin Pharmacol Ther. 2006 Aug; 44(8):358-63.IJ

Abstract

BACKGROUND

Gabapentin and nortriptyline have not been compared in a randomized trial in post-herpetic neuralgia (PHN). The present study was, therefore, undertaken to determine their comparative efficacy and tolerability in the treatment of post-herpetic neuralgia.

PATIENTS AND METHODS

The study was a randomized, double-blind, parallel-group trial of 9 weeks duration. Adult PHN patients with history of > 8 weeks of PHN pain after healing of rash, a pain intensity of at least 40 mm on a 100 mm visual analog scale at screening and at randomization, and average pain score of at least 4 on the Likert scale during the baseline week were included in the study. Gabapentin and nortriptyline were given in incremental doses at 2-weekly intervals till a maximum tolerated dose was obtained. The primary efficacy parameter was change in pain score (11-point Likert scale) from baseline to the end of the study period.

RESULTS

70 patients were available for intention-to-treat analysis. The average pain scores on the Likert scale were significantly reduced at the end of study in both the treatment groups with 47.6% and 42.8% reduction in pain scores in nortriptyline and gabapentin groups, respectively. Patients showed significant improvement in sleep scores in both the treatment groups nortriptyline (46.0%) and gabapentin (52.0%). The VAS and the SF-MPQ scores for pain were significantly reduced in both the groups. Gabapentin was, however, better tolerated as compared to nortriptyline.

CONCLUSION

Gabapentin was shown to be equally efficacious but was better tolerated compared to nortriptyline and can be considered a suitable alternative for the treatment of PHN.

Authors+Show Affiliations

Department of Pharmacology, PGIMER, Chandigarh, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16961166

Citation

Chandra, K, et al. "Gabapentin Versus Nortriptyline in Post-herpetic Neuralgia Patients: a Randomized, Double-blind Clinical Trial--the GONIP Trial." International Journal of Clinical Pharmacology and Therapeutics, vol. 44, no. 8, 2006, pp. 358-63.
Chandra K, Shafiq N, Pandhi P, et al. Gabapentin versus nortriptyline in post-herpetic neuralgia patients: a randomized, double-blind clinical trial--the GONIP Trial. Int J Clin Pharmacol Ther. 2006;44(8):358-63.
Chandra, K., Shafiq, N., Pandhi, P., Gupta, S., & Malhotra, S. (2006). Gabapentin versus nortriptyline in post-herpetic neuralgia patients: a randomized, double-blind clinical trial--the GONIP Trial. International Journal of Clinical Pharmacology and Therapeutics, 44(8), 358-63.
Chandra K, et al. Gabapentin Versus Nortriptyline in Post-herpetic Neuralgia Patients: a Randomized, Double-blind Clinical Trial--the GONIP Trial. Int J Clin Pharmacol Ther. 2006;44(8):358-63. PubMed PMID: 16961166.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gabapentin versus nortriptyline in post-herpetic neuralgia patients: a randomized, double-blind clinical trial--the GONIP Trial. AU - Chandra,K, AU - Shafiq,N, AU - Pandhi,P, AU - Gupta,S, AU - Malhotra,S, PY - 2006/9/12/pubmed PY - 2007/1/17/medline PY - 2006/9/12/entrez SP - 358 EP - 63 JF - International journal of clinical pharmacology and therapeutics JO - Int J Clin Pharmacol Ther VL - 44 IS - 8 N2 - BACKGROUND: Gabapentin and nortriptyline have not been compared in a randomized trial in post-herpetic neuralgia (PHN). The present study was, therefore, undertaken to determine their comparative efficacy and tolerability in the treatment of post-herpetic neuralgia. PATIENTS AND METHODS: The study was a randomized, double-blind, parallel-group trial of 9 weeks duration. Adult PHN patients with history of > 8 weeks of PHN pain after healing of rash, a pain intensity of at least 40 mm on a 100 mm visual analog scale at screening and at randomization, and average pain score of at least 4 on the Likert scale during the baseline week were included in the study. Gabapentin and nortriptyline were given in incremental doses at 2-weekly intervals till a maximum tolerated dose was obtained. The primary efficacy parameter was change in pain score (11-point Likert scale) from baseline to the end of the study period. RESULTS: 70 patients were available for intention-to-treat analysis. The average pain scores on the Likert scale were significantly reduced at the end of study in both the treatment groups with 47.6% and 42.8% reduction in pain scores in nortriptyline and gabapentin groups, respectively. Patients showed significant improvement in sleep scores in both the treatment groups nortriptyline (46.0%) and gabapentin (52.0%). The VAS and the SF-MPQ scores for pain were significantly reduced in both the groups. Gabapentin was, however, better tolerated as compared to nortriptyline. CONCLUSION: Gabapentin was shown to be equally efficacious but was better tolerated compared to nortriptyline and can be considered a suitable alternative for the treatment of PHN. SN - 0946-1965 UR - https://www.unboundmedicine.com/medline/citation/16961166/Gabapentin_versus_nortriptyline_in_post_herpetic_neuralgia_patients:_a_randomized_double_blind_clinical_trial__the_GONIP_Trial_ L2 - https://ClinicalTrials.gov/search/term=16961166 [PUBMED-IDS] DB - PRIME DP - Unbound Medicine ER -