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Gastro-oesophageal reflux of liquids and gas during transient lower oesophageal sphincter relaxations.
Neurogastroenterol Motil 2006; 18(10):888-93NM

Abstract

Some transient lower oesophageal sphincter relaxations (TLOSRs) are accompanied by gastro-oesophageal reflux and others are not. We aimed to investigate what factors determine the occurrence and type of reflux during TLOSRs. In 12 healthy subjects prolonged high-resolution manometry was performed. Reflux was detected using pH-impedance monitoring. A total of 219 TLOSRs were detected; no differences were observed between the duration of TLOSRs with liquid-containing reflux (20.2 +/- 1.0 s), gas reflux (17.0 +/- 1.0 s) and no reflux (19.0 +/- 1.0 s). Trans-sphincteric pressure gradient was similar in TLOSRs with liquid reflux (1.6 +/- 0.1 kPa), gas reflux (1.5 +/- 0.1 kPa) and no reflux (1.7 +/- 0.3 kPa). Prevalence, duration and amplitude of oesophageal pre-contractions and sphincteric after-contractions were not different for TLOSRs with and without reflux. The total number of TLOSRs decreased significantly from 8.2 +/- 0.8 in the first to 5.7 +/- 0.5 in the second and 4.4 +/- 0.6 in the third 70-min recording period. The number of TLOSRs accompanied by liquid-containing reflux decreased from 4.7 +/- 0.9 to 3.0 +/- 0.4 to 1.6 +/- 0.4, while the numbers of TLOSRs with gas reflux remained unchanged (2.1 +/- 0.6-2.1 +/- 0.7-2.2 +/- 0.6). Besides, time after the meal, no differences were observed in the characteristics of TLOSRs with and without gastro-oesophageal reflux. We conclude that factors, other than TLOSR characteristics, are important of whether or not a TLOSR is reflux-related.

Authors+Show Affiliations

Department of Gastroenterology, Sint Antonius Hospital, Nieuwegein, The Netherlands. a.bredenoord@antonius.netNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16961691

Citation

Bredenoord, A J., et al. "Gastro-oesophageal Reflux of Liquids and Gas During Transient Lower Oesophageal Sphincter Relaxations." Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society, vol. 18, no. 10, 2006, pp. 888-93.
Bredenoord AJ, Weusten BL, Timmer R, et al. Gastro-oesophageal reflux of liquids and gas during transient lower oesophageal sphincter relaxations. Neurogastroenterol Motil. 2006;18(10):888-93.
Bredenoord, A. J., Weusten, B. L., Timmer, R., & Smout, A. J. (2006). Gastro-oesophageal reflux of liquids and gas during transient lower oesophageal sphincter relaxations. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society, 18(10), pp. 888-93.
Bredenoord AJ, et al. Gastro-oesophageal Reflux of Liquids and Gas During Transient Lower Oesophageal Sphincter Relaxations. Neurogastroenterol Motil. 2006;18(10):888-93. PubMed PMID: 16961691.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastro-oesophageal reflux of liquids and gas during transient lower oesophageal sphincter relaxations. AU - Bredenoord,A J, AU - Weusten,B L A M, AU - Timmer,R, AU - Smout,A J P M, PY - 2006/9/12/pubmed PY - 2006/10/31/medline PY - 2006/9/12/entrez SP - 888 EP - 93 JF - Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society JO - Neurogastroenterol. Motil. VL - 18 IS - 10 N2 - Some transient lower oesophageal sphincter relaxations (TLOSRs) are accompanied by gastro-oesophageal reflux and others are not. We aimed to investigate what factors determine the occurrence and type of reflux during TLOSRs. In 12 healthy subjects prolonged high-resolution manometry was performed. Reflux was detected using pH-impedance monitoring. A total of 219 TLOSRs were detected; no differences were observed between the duration of TLOSRs with liquid-containing reflux (20.2 +/- 1.0 s), gas reflux (17.0 +/- 1.0 s) and no reflux (19.0 +/- 1.0 s). Trans-sphincteric pressure gradient was similar in TLOSRs with liquid reflux (1.6 +/- 0.1 kPa), gas reflux (1.5 +/- 0.1 kPa) and no reflux (1.7 +/- 0.3 kPa). Prevalence, duration and amplitude of oesophageal pre-contractions and sphincteric after-contractions were not different for TLOSRs with and without reflux. The total number of TLOSRs decreased significantly from 8.2 +/- 0.8 in the first to 5.7 +/- 0.5 in the second and 4.4 +/- 0.6 in the third 70-min recording period. The number of TLOSRs accompanied by liquid-containing reflux decreased from 4.7 +/- 0.9 to 3.0 +/- 0.4 to 1.6 +/- 0.4, while the numbers of TLOSRs with gas reflux remained unchanged (2.1 +/- 0.6-2.1 +/- 0.7-2.2 +/- 0.6). Besides, time after the meal, no differences were observed in the characteristics of TLOSRs with and without gastro-oesophageal reflux. We conclude that factors, other than TLOSR characteristics, are important of whether or not a TLOSR is reflux-related. SN - 1350-1925 UR - https://www.unboundmedicine.com/medline/citation/16961691/Gastro_oesophageal_reflux_of_liquids_and_gas_during_transient_lower_oesophageal_sphincter_relaxations_ L2 - https://doi.org/10.1111/j.1365-2982.2006.00817.x DB - PRIME DP - Unbound Medicine ER -