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Review article: the intestinal lumen as a therapeutic target in inflammatory bowel disease.
Aliment Pharmacol Ther. 2006 Oct; 24 Suppl 3:90-5.AP

Abstract

Undigested carbohydrates reaching the colon can act as competitors for epithelial bacterial receptors, making it difficult for noncommensal bacteria to adhere to them. On the contrary, fermentation of these carbohydrates by anaerobic flora produces - among other substrates - butyrate that is involved in numerous important metabolic processes. These include the provision of energy to the colonocytes, the enhancement of sodium and water absorption and the synthesis of mucus and cell membranes. In addition, butyrate inhibits the nuclear translocation of the transcription factor NFkappaB, which exerts a potent anti-inflammatory activity. Clinical experience with probiotics in inflammatory bowel disease (IBD) is controversial. Whereas some probiotic preparations appear to be useful in ulcerative colitis (UC) and pouchitis, most attempts to use probiotics for treating or preventing recurrence in Crohn's disease have failed. It should be pointed out that - unlike in the small bowel - the colon and ileal pouches are well-established microbiological ecosystems with increasing amounts of a wide variety of bacterial strains. These bacterial strains have a high degree of metabolic interaction with luminal nutrients and a greater probability of developing dysbiosis. With this in mind, the rationale for using pre- and probiotics appears to be stronger for colonic IBD (UC or Crohn's colitis) and pouchitis than for IBD mostly involving the small bowel.

Authors+Show Affiliations

Department of Gastroenterology and Hepatology, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Catalonia, Spain. mgassull.germanstrias@gencat.net

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16961752

Citation

Gassull, M A.. "Review Article: the Intestinal Lumen as a Therapeutic Target in Inflammatory Bowel Disease." Alimentary Pharmacology & Therapeutics, vol. 24 Suppl 3, 2006, pp. 90-5.
Gassull MA. Review article: the intestinal lumen as a therapeutic target in inflammatory bowel disease. Aliment Pharmacol Ther. 2006;24 Suppl 3:90-5.
Gassull, M. A. (2006). Review article: the intestinal lumen as a therapeutic target in inflammatory bowel disease. Alimentary Pharmacology & Therapeutics, 24 Suppl 3, 90-5.
Gassull MA. Review Article: the Intestinal Lumen as a Therapeutic Target in Inflammatory Bowel Disease. Aliment Pharmacol Ther. 2006;24 Suppl 3:90-5. PubMed PMID: 16961752.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Review article: the intestinal lumen as a therapeutic target in inflammatory bowel disease. A1 - Gassull,M A, PY - 2006/9/12/pubmed PY - 2007/5/22/medline PY - 2006/9/12/entrez SP - 90 EP - 5 JF - Alimentary pharmacology & therapeutics JO - Aliment Pharmacol Ther VL - 24 Suppl 3 N2 - Undigested carbohydrates reaching the colon can act as competitors for epithelial bacterial receptors, making it difficult for noncommensal bacteria to adhere to them. On the contrary, fermentation of these carbohydrates by anaerobic flora produces - among other substrates - butyrate that is involved in numerous important metabolic processes. These include the provision of energy to the colonocytes, the enhancement of sodium and water absorption and the synthesis of mucus and cell membranes. In addition, butyrate inhibits the nuclear translocation of the transcription factor NFkappaB, which exerts a potent anti-inflammatory activity. Clinical experience with probiotics in inflammatory bowel disease (IBD) is controversial. Whereas some probiotic preparations appear to be useful in ulcerative colitis (UC) and pouchitis, most attempts to use probiotics for treating or preventing recurrence in Crohn's disease have failed. It should be pointed out that - unlike in the small bowel - the colon and ileal pouches are well-established microbiological ecosystems with increasing amounts of a wide variety of bacterial strains. These bacterial strains have a high degree of metabolic interaction with luminal nutrients and a greater probability of developing dysbiosis. With this in mind, the rationale for using pre- and probiotics appears to be stronger for colonic IBD (UC or Crohn's colitis) and pouchitis than for IBD mostly involving the small bowel. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/16961752/Review_article:_the_intestinal_lumen_as_a_therapeutic_target_in_inflammatory_bowel_disease_ L2 - https://doi.org/10.1111/j.1365-2036.2006.03067.x DB - PRIME DP - Unbound Medicine ER -