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Macrocyclic lactone-resistant Parascaris equorum on stud farms in Canada and effectiveness of fenbendazole and pyrantel pamoate.
Vet Parasitol. 2007 Apr 30; 145(3-4):371-6.VP

Abstract

The aims of studies in 2002 and 2003 on three farms with 76 foals naturally infected with Parascaris equorum were to (i) identify if the nematode was resistant to ivermectin and moxidectin, and (ii) confirm the effectiveness of fenbendazole and pyrantel pamoate for the parasite. Twelve clinical trials, each with a Fecal Egg Count Reduction Test, were conducted on two Thoroughbred and one Standardbred farms in southwestern Ontario, Canada. In each trial, Parascaris eggs/g feces were estimated for each foal pre- and post-treatment using the Cornell-Wisconsin double flotation and Cornell-McMaster dilution techniques. On each farm and for each trial, foals were randomized into treatment groups. Treatments were ivermectin, moxidectin, fenbendazole, pyrantel pamoate administered at the manufacturers' recommended dosages, and some foals were untreated. The overall efficacy for ivermectin was 33.5% (19 foals) and for moxidectin 47.2% (28 foals). Fenbendazole (16 foals) and pyrantel pamoate (21 foals) were highly effective for P. equorum each at 97.6%. For fenbendazole, 15 foals had 100% and for pyrantel pamoate 17 foals had >97% with 14 at 100%.

Authors+Show Affiliations

Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, N1G 2W1 (Slocombe) Canada. oslocomb@uoguelph.caNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16962243

Citation

Slocombe, J Owen D., et al. "Macrocyclic Lactone-resistant Parascaris Equorum On Stud Farms in Canada and Effectiveness of Fenbendazole and Pyrantel Pamoate." Veterinary Parasitology, vol. 145, no. 3-4, 2007, pp. 371-6.
Slocombe JO, de Gannes RV, Lake MC. Macrocyclic lactone-resistant Parascaris equorum on stud farms in Canada and effectiveness of fenbendazole and pyrantel pamoate. Vet Parasitol. 2007;145(3-4):371-6.
Slocombe, J. O., de Gannes, R. V., & Lake, M. C. (2007). Macrocyclic lactone-resistant Parascaris equorum on stud farms in Canada and effectiveness of fenbendazole and pyrantel pamoate. Veterinary Parasitology, 145(3-4), 371-6.
Slocombe JO, de Gannes RV, Lake MC. Macrocyclic Lactone-resistant Parascaris Equorum On Stud Farms in Canada and Effectiveness of Fenbendazole and Pyrantel Pamoate. Vet Parasitol. 2007 Apr 30;145(3-4):371-6. PubMed PMID: 16962243.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Macrocyclic lactone-resistant Parascaris equorum on stud farms in Canada and effectiveness of fenbendazole and pyrantel pamoate. AU - Slocombe,J Owen D, AU - de Gannes,Rolph V G, AU - Lake,Mary C, Y1 - 2006/09/07/ PY - 2006/03/21/received PY - 2006/07/28/revised PY - 2006/08/02/accepted PY - 2006/9/12/pubmed PY - 2007/11/6/medline PY - 2006/9/12/entrez SP - 371 EP - 6 JF - Veterinary parasitology JO - Vet Parasitol VL - 145 IS - 3-4 N2 - The aims of studies in 2002 and 2003 on three farms with 76 foals naturally infected with Parascaris equorum were to (i) identify if the nematode was resistant to ivermectin and moxidectin, and (ii) confirm the effectiveness of fenbendazole and pyrantel pamoate for the parasite. Twelve clinical trials, each with a Fecal Egg Count Reduction Test, were conducted on two Thoroughbred and one Standardbred farms in southwestern Ontario, Canada. In each trial, Parascaris eggs/g feces were estimated for each foal pre- and post-treatment using the Cornell-Wisconsin double flotation and Cornell-McMaster dilution techniques. On each farm and for each trial, foals were randomized into treatment groups. Treatments were ivermectin, moxidectin, fenbendazole, pyrantel pamoate administered at the manufacturers' recommended dosages, and some foals were untreated. The overall efficacy for ivermectin was 33.5% (19 foals) and for moxidectin 47.2% (28 foals). Fenbendazole (16 foals) and pyrantel pamoate (21 foals) were highly effective for P. equorum each at 97.6%. For fenbendazole, 15 foals had 100% and for pyrantel pamoate 17 foals had >97% with 14 at 100%. SN - 0304-4017 UR - https://www.unboundmedicine.com/medline/citation/16962243/Macrocyclic_lactone_resistant_Parascaris_equorum_on_stud_farms_in_Canada_and_effectiveness_of_fenbendazole_and_pyrantel_pamoate_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-4017(06)00471-7 DB - PRIME DP - Unbound Medicine ER -