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NMDA antagonist AP-5 increase environmentally induced cocaine-conditioned locomotion within the nucleus accumbens.
Pharmacol Biochem Behav. 2006 Sep; 85(1):178-84.PB

Abstract

An environment previously associated with cocaine use can elicit cravings, even in the absence of the drug, which may be due to the formation of strong associations between the environment and the drug. These associations can result from motor learning and reinforcing effects of cocaine, and may be mediated in part by ionotropic glutamate receptors in the nucleus accumbens (N.Acc.). To determine whether NMDA receptor activity in the N.Acc. affects the expression of conditioned locomotion, rats were trained using an environment-elicited cocaine-conditioning paradigm. Rats trained to pair a cocaine injection with an environment showed an increased locomotor activity when tested in the drug-paired environment, whereas rats injected with cocaine in their home cages did not exhibit greater locomotion. Significantly greater locomotor activity occurred in trained animals that received an infusion of AP-5, a NMDA receptor antagonist, into the N.Acc. These results suggest that animals trained to associate environmental cues with cocaine become conditioned to this environment. Furthermore, our finding demonstrates that NMDA receptor activation within the N.Acc. modulates cocaine-induced conditioning.

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Authors+Show Affiliations

Rodríguez-Borrero E
University of Puerto Rico, Río Piedras Campus, Biology Department, San Juan, Puerto Rico.
Bernardo Colón A
No affiliation info available
Burgos-Mártir MA
No affiliation info available
Alvarez Carillo JE
No affiliation info available
del Campo YE
No affiliation info available
Abella-Ramírez C
No affiliation info available
Maldonado-Vlaar CS
No affiliation info available

MeSH

2-Amino-5-phosphonovalerateAnimalsBehavior, AnimalCocaineEnzyme-Linked Immunosorbent AssayExcitatory Amino Acid AntagonistsLocomotionMaleNucleus AccumbensRatsRats, Sprague-DawleyReceptors, N-Methyl-D-Aspartate

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16963113

Citation

Rodríguez-Borrero, Enrique, et al. "NMDA Antagonist AP-5 Increase Environmentally Induced Cocaine-conditioned Locomotion Within the Nucleus Accumbens." Pharmacology, Biochemistry, and Behavior, vol. 85, no. 1, 2006, pp. 178-84.
Rodríguez-Borrero E, Bernardo Colón A, Burgos-Mártir MA, et al. NMDA antagonist AP-5 increase environmentally induced cocaine-conditioned locomotion within the nucleus accumbens. Pharmacol Biochem Behav. 2006;85(1):178-84.
Rodríguez-Borrero, E., Bernardo Colón, A., Burgos-Mártir, M. A., Alvarez Carillo, J. E., del Campo, Y. E., Abella-Ramírez, C., & Maldonado-Vlaar, C. S. (2006). NMDA antagonist AP-5 increase environmentally induced cocaine-conditioned locomotion within the nucleus accumbens. Pharmacology, Biochemistry, and Behavior, 85(1), 178-84.
Rodríguez-Borrero E, et al. NMDA Antagonist AP-5 Increase Environmentally Induced Cocaine-conditioned Locomotion Within the Nucleus Accumbens. Pharmacol Biochem Behav. 2006;85(1):178-84. PubMed PMID: 16963113.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - NMDA antagonist AP-5 increase environmentally induced cocaine-conditioned locomotion within the nucleus accumbens. AU - Rodríguez-Borrero,Enrique, AU - Bernardo Colón,Alexandra, AU - Burgos-Mártir,Melissa A, AU - Alvarez Carillo,José E, AU - del Campo,Yaniré Estrada, AU - Abella-Ramírez,Cynthia, AU - Maldonado-Vlaar,Carmen S, Y1 - 2006/09/11/ PY - 2005/05/06/received PY - 2006/07/14/revised PY - 2006/07/28/accepted PY - 2006/9/12/pubmed PY - 2007/2/24/medline PY - 2006/9/12/entrez SP - 178 EP - 84 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol Biochem Behav VL - 85 IS - 1 N2 - An environment previously associated with cocaine use can elicit cravings, even in the absence of the drug, which may be due to the formation of strong associations between the environment and the drug. These associations can result from motor learning and reinforcing effects of cocaine, and may be mediated in part by ionotropic glutamate receptors in the nucleus accumbens (N.Acc.). To determine whether NMDA receptor activity in the N.Acc. affects the expression of conditioned locomotion, rats were trained using an environment-elicited cocaine-conditioning paradigm. Rats trained to pair a cocaine injection with an environment showed an increased locomotor activity when tested in the drug-paired environment, whereas rats injected with cocaine in their home cages did not exhibit greater locomotion. Significantly greater locomotor activity occurred in trained animals that received an infusion of AP-5, a NMDA receptor antagonist, into the N.Acc. These results suggest that animals trained to associate environmental cues with cocaine become conditioned to this environment. Furthermore, our finding demonstrates that NMDA receptor activation within the N.Acc. modulates cocaine-induced conditioning. SN - 0091-3057 UR - https://www.unboundmedicine.com/medline/citation/16963113/NMDA_antagonist_AP_5_increase_environmentally_induced_cocaine_conditioned_locomotion_within_the_nucleus_accumbens_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(06)00254-1 DB - PRIME DP - Unbound Medicine ER -