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Ceramide/sphingosine/sphingosine 1-phosphate metabolism on the cell surface and in the extracellular space.
Cell Signal 2007; 19(2):229-37CS

Abstract

Sphingolipid metabolites, ceramide, sphingosine, and sphingosine 1-phosphate, have emerged as a new class of lipid biomodulators of various cell functions. These metabolites are known to function not only as intracellular second messengers, but also in the extracellular space. Sphingosine 1-phosphate especially has numerous functions as an important extracellular mediator that binds to cell surface S1P receptors. Recent studies have also shown that sphingolipid-metabolizing enzymes function not only in intracellular organelles but also in the extracellular spaces, including the outer leaflet of the plasma membrane. This review focuses on the metabolic enzymes (acid and alkaline sphingomyelinases, neutral ceramidase, and sphingosine kinase) that are involved in the production of the sphingolipid metabolites in these extracellular spaces, and on the metabolic pathway itself.

Authors+Show Affiliations

Department of Biomembrane and Biofunctional Chemistry, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12-Nishi 6, Kita-ku, Sapporo 060-0812, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

16963225

Citation

Tani, Motohiro, et al. "Ceramide/sphingosine/sphingosine 1-phosphate Metabolism On the Cell Surface and in the Extracellular Space." Cellular Signalling, vol. 19, no. 2, 2007, pp. 229-37.
Tani M, Ito M, Igarashi Y. Ceramide/sphingosine/sphingosine 1-phosphate metabolism on the cell surface and in the extracellular space. Cell Signal. 2007;19(2):229-37.
Tani, M., Ito, M., & Igarashi, Y. (2007). Ceramide/sphingosine/sphingosine 1-phosphate metabolism on the cell surface and in the extracellular space. Cellular Signalling, 19(2), pp. 229-37.
Tani M, Ito M, Igarashi Y. Ceramide/sphingosine/sphingosine 1-phosphate Metabolism On the Cell Surface and in the Extracellular Space. Cell Signal. 2007;19(2):229-37. PubMed PMID: 16963225.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ceramide/sphingosine/sphingosine 1-phosphate metabolism on the cell surface and in the extracellular space. AU - Tani,Motohiro, AU - Ito,Makoto, AU - Igarashi,Yasuyuki, Y1 - 2006/09/11/ PY - 2006/04/03/received PY - 2006/07/03/revised PY - 2006/07/04/accepted PY - 2006/9/12/pubmed PY - 2007/2/28/medline PY - 2006/9/12/entrez SP - 229 EP - 37 JF - Cellular signalling JO - Cell. Signal. VL - 19 IS - 2 N2 - Sphingolipid metabolites, ceramide, sphingosine, and sphingosine 1-phosphate, have emerged as a new class of lipid biomodulators of various cell functions. These metabolites are known to function not only as intracellular second messengers, but also in the extracellular space. Sphingosine 1-phosphate especially has numerous functions as an important extracellular mediator that binds to cell surface S1P receptors. Recent studies have also shown that sphingolipid-metabolizing enzymes function not only in intracellular organelles but also in the extracellular spaces, including the outer leaflet of the plasma membrane. This review focuses on the metabolic enzymes (acid and alkaline sphingomyelinases, neutral ceramidase, and sphingosine kinase) that are involved in the production of the sphingolipid metabolites in these extracellular spaces, and on the metabolic pathway itself. SN - 0898-6568 UR - https://www.unboundmedicine.com/medline/citation/16963225/Ceramide/sphingosine/sphingosine_1_phosphate_metabolism_on_the_cell_surface_and_in_the_extracellular_space_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0898-6568(06)00157-4 DB - PRIME DP - Unbound Medicine ER -