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Effects of a low-fat, high-fiber diet and exercise program on breast cancer risk factors in vivo and tumor cell growth and apoptosis in vitro.
Nutr Cancer. 2006; 55(1):28-34.NC

Abstract

The present study investigated the effects of a diet and exercise intervention on known breast cancer (BCa) risk factors, including estrogen, obesity, insulin, and insulin-like growth factor-I (IGF-I), in overweight/obese, postmenopausal women. In addition, using the subjects' pre- and postintervention serum in vitro, serum-stimulated growth and apoptosis of three estrogen receptor-positive BCa cell lines were studied. The women where placed on a low-fat (10-15% kcal), high-fiber (30-40 g per 1,000 kcal/day) diet and attended daily exercise classes for 2 wk. Serum estradiol was reduced in the women on hormone treatment (HT; n = 28) as well as those not on HT (n = 10). Serum insulin and IGF-I were significantly reduced in all women, whereas IGF binding protein-1 was increased significantly. In vitro growth of the BCa cell lines was reduced by 6.6% for the MCF-7 cells, 9.9% for the ZR-75-1 cells, and 18.5% for the T-47D cells. Apoptosis was increased by 20% in the ZR-75-1 cells, 23% in the MCF-7 cells, and 30% in the T-47D cells (n = 12). These results show that a very-low-fat, high-fiber diet combined with daily exercise results in major reductions in risk factors for BCa while subjects remained overweight/obese. These in vivo serum changes slowed the growth and induced apoptosis in serum-stimulated BCa cell lines in vitro.

Authors+Show Affiliations

Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095-1606, USA. jbarnard@physci.ucla.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16965238

Citation

Barnard, R James, et al. "Effects of a Low-fat, High-fiber Diet and Exercise Program On Breast Cancer Risk Factors in Vivo and Tumor Cell Growth and Apoptosis in Vitro." Nutrition and Cancer, vol. 55, no. 1, 2006, pp. 28-34.
Barnard RJ, Gonzalez JH, Liva ME, et al. Effects of a low-fat, high-fiber diet and exercise program on breast cancer risk factors in vivo and tumor cell growth and apoptosis in vitro. Nutr Cancer. 2006;55(1):28-34.
Barnard, R. J., Gonzalez, J. H., Liva, M. E., & Ngo, T. H. (2006). Effects of a low-fat, high-fiber diet and exercise program on breast cancer risk factors in vivo and tumor cell growth and apoptosis in vitro. Nutrition and Cancer, 55(1), 28-34.
Barnard RJ, et al. Effects of a Low-fat, High-fiber Diet and Exercise Program On Breast Cancer Risk Factors in Vivo and Tumor Cell Growth and Apoptosis in Vitro. Nutr Cancer. 2006;55(1):28-34. PubMed PMID: 16965238.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of a low-fat, high-fiber diet and exercise program on breast cancer risk factors in vivo and tumor cell growth and apoptosis in vitro. AU - Barnard,R James, AU - Gonzalez,Jenny Hong, AU - Liva,Maud E, AU - Ngo,Tung H, PY - 2006/9/13/pubmed PY - 2007/1/17/medline PY - 2006/9/13/entrez SP - 28 EP - 34 JF - Nutrition and cancer JO - Nutr Cancer VL - 55 IS - 1 N2 - The present study investigated the effects of a diet and exercise intervention on known breast cancer (BCa) risk factors, including estrogen, obesity, insulin, and insulin-like growth factor-I (IGF-I), in overweight/obese, postmenopausal women. In addition, using the subjects' pre- and postintervention serum in vitro, serum-stimulated growth and apoptosis of three estrogen receptor-positive BCa cell lines were studied. The women where placed on a low-fat (10-15% kcal), high-fiber (30-40 g per 1,000 kcal/day) diet and attended daily exercise classes for 2 wk. Serum estradiol was reduced in the women on hormone treatment (HT; n = 28) as well as those not on HT (n = 10). Serum insulin and IGF-I were significantly reduced in all women, whereas IGF binding protein-1 was increased significantly. In vitro growth of the BCa cell lines was reduced by 6.6% for the MCF-7 cells, 9.9% for the ZR-75-1 cells, and 18.5% for the T-47D cells. Apoptosis was increased by 20% in the ZR-75-1 cells, 23% in the MCF-7 cells, and 30% in the T-47D cells (n = 12). These results show that a very-low-fat, high-fiber diet combined with daily exercise results in major reductions in risk factors for BCa while subjects remained overweight/obese. These in vivo serum changes slowed the growth and induced apoptosis in serum-stimulated BCa cell lines in vitro. SN - 0163-5581 UR - https://www.unboundmedicine.com/medline/citation/16965238/Effects_of_a_low_fat_high_fiber_diet_and_exercise_program_on_breast_cancer_risk_factors_in_vivo_and_tumor_cell_growth_and_apoptosis_in_vitro_ L2 - http://www.tandfonline.com/doi/full/10.1207/s15327914nc5501_4 DB - PRIME DP - Unbound Medicine ER -