Tags

Type your tag names separated by a space and hit enter

Antioxidant vitamins and risk of gastric cancer: a case-control study in Portugal.
Nutr Cancer 2006; 55(1):71-7NC

Abstract

We quantified the effect of antioxidant vitamins in gastric cancer risk, taking into account Helicobacter pylori seropositivity and overall fruit and vegetable intake. Incident cases were identified in two large hospitals in Porto, Portugal, and controls were randomly sampled among city dwellers. Food intake was assessed with a previously validated semiquantitative food-frequency questionnaire. A commercially available chromatographic immunoassay was used for the detection of immunoglobulin G antibodies. Complete questionnaire information and serum samples were available for 233 cases and 311 controls. Compared with subjects in the lowest tertile of dietary intake, the odds ratios (ORs) for those in the highest were 0.85 (95% confidence interval, CI = 0.45-1.60) for vitamin C, 1.04 (95% CI = 0.60-1.80) for vitamin E, and 1.33 (95% CI = 0.77-2.30) for provitamin A carotenoids after further adjusting for fruit and vegetable consumption. Fruit and vegetables remained an independent protective factor (OR = 0.45; 95% CI = 0.23-0.89) after further adjustment for the intake of antioxidant vitamins. H. pylori status had no significant interaction with dietary items. Factors other than H. pylori infection and intake of vitamin C and provitamin A carotenoids seem to account for the inverse association between fruit and vegetable consumption and gastric cancer.

Authors+Show Affiliations

Department of Hygiene and Epidemiology, University of Porto Medical School, Porto, Portugal. nlunet@med.up.ptNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16965243

Citation

Lunet, Nuno, et al. "Antioxidant Vitamins and Risk of Gastric Cancer: a Case-control Study in Portugal." Nutrition and Cancer, vol. 55, no. 1, 2006, pp. 71-7.
Lunet N, Valbuena C, Carneiro F, et al. Antioxidant vitamins and risk of gastric cancer: a case-control study in Portugal. Nutr Cancer. 2006;55(1):71-7.
Lunet, N., Valbuena, C., Carneiro, F., Lopes, C., & Barros, H. (2006). Antioxidant vitamins and risk of gastric cancer: a case-control study in Portugal. Nutrition and Cancer, 55(1), pp. 71-7.
Lunet N, et al. Antioxidant Vitamins and Risk of Gastric Cancer: a Case-control Study in Portugal. Nutr Cancer. 2006;55(1):71-7. PubMed PMID: 16965243.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant vitamins and risk of gastric cancer: a case-control study in Portugal. AU - Lunet,Nuno, AU - Valbuena,Carmen, AU - Carneiro,Fátima, AU - Lopes,Carlos, AU - Barros,Henrique, PY - 2006/9/13/pubmed PY - 2007/1/17/medline PY - 2006/9/13/entrez SP - 71 EP - 7 JF - Nutrition and cancer JO - Nutr Cancer VL - 55 IS - 1 N2 - We quantified the effect of antioxidant vitamins in gastric cancer risk, taking into account Helicobacter pylori seropositivity and overall fruit and vegetable intake. Incident cases were identified in two large hospitals in Porto, Portugal, and controls were randomly sampled among city dwellers. Food intake was assessed with a previously validated semiquantitative food-frequency questionnaire. A commercially available chromatographic immunoassay was used for the detection of immunoglobulin G antibodies. Complete questionnaire information and serum samples were available for 233 cases and 311 controls. Compared with subjects in the lowest tertile of dietary intake, the odds ratios (ORs) for those in the highest were 0.85 (95% confidence interval, CI = 0.45-1.60) for vitamin C, 1.04 (95% CI = 0.60-1.80) for vitamin E, and 1.33 (95% CI = 0.77-2.30) for provitamin A carotenoids after further adjusting for fruit and vegetable consumption. Fruit and vegetables remained an independent protective factor (OR = 0.45; 95% CI = 0.23-0.89) after further adjustment for the intake of antioxidant vitamins. H. pylori status had no significant interaction with dietary items. Factors other than H. pylori infection and intake of vitamin C and provitamin A carotenoids seem to account for the inverse association between fruit and vegetable consumption and gastric cancer. SN - 0163-5581 UR - https://www.unboundmedicine.com/medline/citation/16965243/Antioxidant_vitamins_and_risk_of_gastric_cancer:_a_case_control_study_in_Portugal_ L2 - http://www.tandfonline.com/doi/full/10.1207/s15327914nc5501_9 DB - PRIME DP - Unbound Medicine ER -