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Antioxidant vitamins and risk of gastric cancer: a case-control study in Portugal.

Abstract

We quantified the effect of antioxidant vitamins in gastric cancer risk, taking into account Helicobacter pylori seropositivity and overall fruit and vegetable intake. Incident cases were identified in two large hospitals in Porto, Portugal, and controls were randomly sampled among city dwellers. Food intake was assessed with a previously validated semiquantitative food-frequency questionnaire. A commercially available chromatographic immunoassay was used for the detection of immunoglobulin G antibodies. Complete questionnaire information and serum samples were available for 233 cases and 311 controls. Compared with subjects in the lowest tertile of dietary intake, the odds ratios (ORs) for those in the highest were 0.85 (95% confidence interval, CI = 0.45-1.60) for vitamin C, 1.04 (95% CI = 0.60-1.80) for vitamin E, and 1.33 (95% CI = 0.77-2.30) for provitamin A carotenoids after further adjusting for fruit and vegetable consumption. Fruit and vegetables remained an independent protective factor (OR = 0.45; 95% CI = 0.23-0.89) after further adjustment for the intake of antioxidant vitamins. H. pylori status had no significant interaction with dietary items. Factors other than H. pylori infection and intake of vitamin C and provitamin A carotenoids seem to account for the inverse association between fruit and vegetable consumption and gastric cancer.

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  • Authors+Show Affiliations

    ,

    Department of Hygiene and Epidemiology, University of Porto Medical School, Porto, Portugal. nlunet@med.up.pt

    , , ,

    Source

    Nutrition and cancer 55:1 2006 pg 71-7

    MeSH

    Aged
    Antioxidants
    Ascorbic Acid
    Case-Control Studies
    Confidence Intervals
    Diet
    Diet Surveys
    Female
    Fruit
    Helicobacter Infections
    Helicobacter pylori
    Humans
    Immunoglobulin G
    Male
    Middle Aged
    Odds Ratio
    Portugal
    Risk Factors
    Stomach Neoplasms
    Surveys and Questionnaires
    Vegetables
    Vitamin E
    Vitamins

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    16965243

    Citation

    Lunet, Nuno, et al. "Antioxidant Vitamins and Risk of Gastric Cancer: a Case-control Study in Portugal." Nutrition and Cancer, vol. 55, no. 1, 2006, pp. 71-7.
    Lunet N, Valbuena C, Carneiro F, et al. Antioxidant vitamins and risk of gastric cancer: a case-control study in Portugal. Nutr Cancer. 2006;55(1):71-7.
    Lunet, N., Valbuena, C., Carneiro, F., Lopes, C., & Barros, H. (2006). Antioxidant vitamins and risk of gastric cancer: a case-control study in Portugal. Nutrition and Cancer, 55(1), pp. 71-7.
    Lunet N, et al. Antioxidant Vitamins and Risk of Gastric Cancer: a Case-control Study in Portugal. Nutr Cancer. 2006;55(1):71-7. PubMed PMID: 16965243.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Antioxidant vitamins and risk of gastric cancer: a case-control study in Portugal. AU - Lunet,Nuno, AU - Valbuena,Carmen, AU - Carneiro,Fátima, AU - Lopes,Carlos, AU - Barros,Henrique, PY - 2006/9/13/pubmed PY - 2007/1/17/medline PY - 2006/9/13/entrez SP - 71 EP - 7 JF - Nutrition and cancer JO - Nutr Cancer VL - 55 IS - 1 N2 - We quantified the effect of antioxidant vitamins in gastric cancer risk, taking into account Helicobacter pylori seropositivity and overall fruit and vegetable intake. Incident cases were identified in two large hospitals in Porto, Portugal, and controls were randomly sampled among city dwellers. Food intake was assessed with a previously validated semiquantitative food-frequency questionnaire. A commercially available chromatographic immunoassay was used for the detection of immunoglobulin G antibodies. Complete questionnaire information and serum samples were available for 233 cases and 311 controls. Compared with subjects in the lowest tertile of dietary intake, the odds ratios (ORs) for those in the highest were 0.85 (95% confidence interval, CI = 0.45-1.60) for vitamin C, 1.04 (95% CI = 0.60-1.80) for vitamin E, and 1.33 (95% CI = 0.77-2.30) for provitamin A carotenoids after further adjusting for fruit and vegetable consumption. Fruit and vegetables remained an independent protective factor (OR = 0.45; 95% CI = 0.23-0.89) after further adjustment for the intake of antioxidant vitamins. H. pylori status had no significant interaction with dietary items. Factors other than H. pylori infection and intake of vitamin C and provitamin A carotenoids seem to account for the inverse association between fruit and vegetable consumption and gastric cancer. SN - 0163-5581 UR - https://www.unboundmedicine.com/medline/citation/16965243/Antioxidant_vitamins_and_risk_of_gastric_cancer:_a_case_control_study_in_Portugal_ L2 - http://www.tandfonline.com/doi/full/10.1207/s15327914nc5501_9 DB - PRIME DP - Unbound Medicine ER -