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Implications of previous subclinical dengue infection but not virus load in dengue hemorrhagic fever.
FEMS Immunol Med Microbiol. 2006 Oct; 48(1):84-90.FI

Abstract

In a study comparing the virus load and immune reaction between patients with primary and secondary dengue-2 (DEN-2) infections in a hospital-based analysis, we found that 40.7% (55/135) of the 135 patients had secondary DEN-2 infection following a DEN-2 outbreak in southern Taiwan. Most of the secondary infections had subclinical primary dengue infections (78.2%; 43/55). Patients with secondary DEN-2 infections had lower platelet counts, and blood interferon-alpha and virus load, but significantly higher interleukin-10 (P=0.030) and anti-DEN-1 neutralization titers (P=0.013) than those with primary infection. Patients with secondary DEN-2 infection also had a higher rate of dengue hemorrhagic fever (DHF) (61.7% vs. 36.3%). A previous subclinical dengue infection is involved in the secondary DEN-2 infection associated with altered immune reaction and higher DHF rate, but lower blood virus load.

Authors+Show Affiliations

Department of Medical Research, Chang Gung Memorial Hospital at Kaohsiung, Chang Gung University College of Medicine, Niau-Sung, Kaohsiung, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16965355

Citation

Yeh, Wen-Ting, et al. "Implications of Previous Subclinical Dengue Infection but Not Virus Load in Dengue Hemorrhagic Fever." FEMS Immunology and Medical Microbiology, vol. 48, no. 1, 2006, pp. 84-90.
Yeh WT, Chen RF, Wang L, et al. Implications of previous subclinical dengue infection but not virus load in dengue hemorrhagic fever. FEMS Immunol Med Microbiol. 2006;48(1):84-90.
Yeh, W. T., Chen, R. F., Wang, L., Liu, J. W., Shaio, M. F., & Yang, K. D. (2006). Implications of previous subclinical dengue infection but not virus load in dengue hemorrhagic fever. FEMS Immunology and Medical Microbiology, 48(1), 84-90.
Yeh WT, et al. Implications of Previous Subclinical Dengue Infection but Not Virus Load in Dengue Hemorrhagic Fever. FEMS Immunol Med Microbiol. 2006;48(1):84-90. PubMed PMID: 16965355.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Implications of previous subclinical dengue infection but not virus load in dengue hemorrhagic fever. AU - Yeh,Wen-Ting, AU - Chen,Rong-Fu, AU - Wang,Lin, AU - Liu,Jien-Wei, AU - Shaio,Men-Fang, AU - Yang,Kuender D, PY - 2006/9/13/pubmed PY - 2006/12/9/medline PY - 2006/9/13/entrez SP - 84 EP - 90 JF - FEMS immunology and medical microbiology JO - FEMS Immunol Med Microbiol VL - 48 IS - 1 N2 - In a study comparing the virus load and immune reaction between patients with primary and secondary dengue-2 (DEN-2) infections in a hospital-based analysis, we found that 40.7% (55/135) of the 135 patients had secondary DEN-2 infection following a DEN-2 outbreak in southern Taiwan. Most of the secondary infections had subclinical primary dengue infections (78.2%; 43/55). Patients with secondary DEN-2 infections had lower platelet counts, and blood interferon-alpha and virus load, but significantly higher interleukin-10 (P=0.030) and anti-DEN-1 neutralization titers (P=0.013) than those with primary infection. Patients with secondary DEN-2 infection also had a higher rate of dengue hemorrhagic fever (DHF) (61.7% vs. 36.3%). A previous subclinical dengue infection is involved in the secondary DEN-2 infection associated with altered immune reaction and higher DHF rate, but lower blood virus load. SN - 0928-8244 UR - https://www.unboundmedicine.com/medline/citation/16965355/Implications_of_previous_subclinical_dengue_infection_but_not_virus_load_in_dengue_hemorrhagic_fever_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0928-8244&date=2006&volume=48&issue=1&spage=84 DB - PRIME DP - Unbound Medicine ER -