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Effects of transfusion on human erythrovirus B19-susceptible or -infected pediatric recipients in a genotype 3-endemic area.
Transfusion. 2006 Sep; 46(9):1593-600.T

Abstract

BACKGROUND

Human erythrovirus (parvovirus) B19 is transmitted by transfusion of blood, blood components, and plasma derivatives and is resistant to most viral inactivation methods. B19 genotype 3 is prevalent in Ghana, and no related clinical information is available.

STUDY DESIGN AND METHODS

This study assessed the transmission of B19 genotype 3 by transfusion and the potential effect of transfused B19 antibodies in viremic recipients. Immunological aspects of B19 genotype 3 infection in children mainly transfused for acute malarial anemia were examined. Molecular and serologic methods adapted to genotype 3 were developed and used.

RESULTS

Among 114 donor-recipient pairs from Ghana, two donations contained B19 DNA and specific antibodies, and no evidence of transmission was found. B19 immunoglobulin G (IgG)-containing whole blood was transfused to 14 B19 DNA-positive recipients. Three recipients with detectable levels of IgG to B19 failed to clear viremia 1 to 2.3 months after transfusion. Ten recipients without IgG to VP2 before transfusion cleared the virus but failed to develop an immune response to B19 within 1 to 2 months after transfusion. Only 1 patient who received little specific IgG by transfusion produced detectable antibodies.

CONCLUSION

Low levels of B19 genotype 3 DNA associated with specific IgG are not infectious by transfusion. Viral clearance and apparent down regulation of immune response to B19 may be related to removal of the viral antigens by transfused antibodies and/or immunomodulatory effect of transfusion.

Authors+Show Affiliations

Division of Transfusion Medicine, Department of Haematology, University of Cambridge, Cambridge, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16965589

Citation

Parsyan, Armen, et al. "Effects of Transfusion On Human Erythrovirus B19-susceptible or -infected Pediatric Recipients in a Genotype 3-endemic Area." Transfusion, vol. 46, no. 9, 2006, pp. 1593-600.
Parsyan A, Addo-Yobo E, Owusu-Ofori S, et al. Effects of transfusion on human erythrovirus B19-susceptible or -infected pediatric recipients in a genotype 3-endemic area. Transfusion. 2006;46(9):1593-600.
Parsyan, A., Addo-Yobo, E., Owusu-Ofori, S., Akpene, H., Sarkodie, F., & Allain, J. P. (2006). Effects of transfusion on human erythrovirus B19-susceptible or -infected pediatric recipients in a genotype 3-endemic area. Transfusion, 46(9), 1593-600.
Parsyan A, et al. Effects of Transfusion On Human Erythrovirus B19-susceptible or -infected Pediatric Recipients in a Genotype 3-endemic Area. Transfusion. 2006;46(9):1593-600. PubMed PMID: 16965589.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of transfusion on human erythrovirus B19-susceptible or -infected pediatric recipients in a genotype 3-endemic area. AU - Parsyan,Armen, AU - Addo-Yobo,Emmanuel, AU - Owusu-Ofori,Shirley, AU - Akpene,Henrietta, AU - Sarkodie,Francis, AU - Allain,Jean-Pierre, PY - 2006/9/13/pubmed PY - 2006/10/18/medline PY - 2006/9/13/entrez SP - 1593 EP - 600 JF - Transfusion JO - Transfusion VL - 46 IS - 9 N2 - BACKGROUND: Human erythrovirus (parvovirus) B19 is transmitted by transfusion of blood, blood components, and plasma derivatives and is resistant to most viral inactivation methods. B19 genotype 3 is prevalent in Ghana, and no related clinical information is available. STUDY DESIGN AND METHODS: This study assessed the transmission of B19 genotype 3 by transfusion and the potential effect of transfused B19 antibodies in viremic recipients. Immunological aspects of B19 genotype 3 infection in children mainly transfused for acute malarial anemia were examined. Molecular and serologic methods adapted to genotype 3 were developed and used. RESULTS: Among 114 donor-recipient pairs from Ghana, two donations contained B19 DNA and specific antibodies, and no evidence of transmission was found. B19 immunoglobulin G (IgG)-containing whole blood was transfused to 14 B19 DNA-positive recipients. Three recipients with detectable levels of IgG to B19 failed to clear viremia 1 to 2.3 months after transfusion. Ten recipients without IgG to VP2 before transfusion cleared the virus but failed to develop an immune response to B19 within 1 to 2 months after transfusion. Only 1 patient who received little specific IgG by transfusion produced detectable antibodies. CONCLUSION: Low levels of B19 genotype 3 DNA associated with specific IgG are not infectious by transfusion. Viral clearance and apparent down regulation of immune response to B19 may be related to removal of the viral antigens by transfused antibodies and/or immunomodulatory effect of transfusion. SN - 0041-1132 UR - https://www.unboundmedicine.com/medline/citation/16965589/Effects_of_transfusion_on_human_erythrovirus_B19_susceptible_or__infected_pediatric_recipients_in_a_genotype_3_endemic_area_ L2 - https://doi.org/10.1111/j.1537-2995.2006.00952.x DB - PRIME DP - Unbound Medicine ER -