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Older adults with cognitive complaints show brain atrophy similar to that of amnestic MCI.
Neurology 2006; 67(5):834-42Neur

Abstract

OBJECTIVE

To examine the neural basis of cognitive complaints in healthy older adults in the absence of memory impairment and to determine whether there are medial temporal lobe (MTL) gray matter (GM) changes as reported in Alzheimer disease (AD) and amnestic mild cognitive impairment (MCI).

METHODS

Participants were 40 euthymic individuals with cognitive complaints (CCs) who had normal neuropsychological test performance. The authors compared their structural brain MRI scans to those of 40 patients with amnestic MCI and 40 healthy controls (HCs) using voxel-based morphometry and hippocampal volume analysis.

RESULTS

The CC and MCI groups showed similar patterns of decreased GM relative to the HC group on whole brain analysis, with differences evident in the MTL, frontotemporal, and other neocortical regions. The degree of GM loss was associated with extent of both memory complaints and performance deficits. Manually segmented hippocampal volumes, adjusted for age and intracranial volume, were significantly reduced only in the MCI group, with the CC group showing an intermediate level.

CONCLUSIONS

Cognitive complaints in older adults may indicate underlying neurodegenerative changes even when unaccompanied by deficits on formal testing. The cognitive complaint group may represent a pre-mild cognitive impairment stage and may provide an earlier therapeutic opportunity than mild cognitive impairment. MRI analysis approaches incorporating signal intensity may have greater sensitivity in early preclinical stages than volumetric methods.

Authors+Show Affiliations

Brain Imaging Laboratory, Department of Psychiatry, Dartmouth Medical School, Hanover, NH, USA. andrew.saykin@dartmouth.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

16966547

Citation

Saykin, A J., et al. "Older Adults With Cognitive Complaints Show Brain Atrophy Similar to That of Amnestic MCI." Neurology, vol. 67, no. 5, 2006, pp. 834-42.
Saykin AJ, Wishart HA, Rabin LA, et al. Older adults with cognitive complaints show brain atrophy similar to that of amnestic MCI. Neurology. 2006;67(5):834-42.
Saykin, A. J., Wishart, H. A., Rabin, L. A., Santulli, R. B., Flashman, L. A., West, J. D., ... Mamourian, A. C. (2006). Older adults with cognitive complaints show brain atrophy similar to that of amnestic MCI. Neurology, 67(5), pp. 834-42.
Saykin AJ, et al. Older Adults With Cognitive Complaints Show Brain Atrophy Similar to That of Amnestic MCI. Neurology. 2006 Sep 12;67(5):834-42. PubMed PMID: 16966547.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Older adults with cognitive complaints show brain atrophy similar to that of amnestic MCI. AU - Saykin,A J, AU - Wishart,H A, AU - Rabin,L A, AU - Santulli,R B, AU - Flashman,L A, AU - West,J D, AU - McHugh,T L, AU - Mamourian,A C, PY - 2006/9/13/pubmed PY - 2006/9/27/medline PY - 2006/9/13/entrez SP - 834 EP - 42 JF - Neurology JO - Neurology VL - 67 IS - 5 N2 - OBJECTIVE: To examine the neural basis of cognitive complaints in healthy older adults in the absence of memory impairment and to determine whether there are medial temporal lobe (MTL) gray matter (GM) changes as reported in Alzheimer disease (AD) and amnestic mild cognitive impairment (MCI). METHODS: Participants were 40 euthymic individuals with cognitive complaints (CCs) who had normal neuropsychological test performance. The authors compared their structural brain MRI scans to those of 40 patients with amnestic MCI and 40 healthy controls (HCs) using voxel-based morphometry and hippocampal volume analysis. RESULTS: The CC and MCI groups showed similar patterns of decreased GM relative to the HC group on whole brain analysis, with differences evident in the MTL, frontotemporal, and other neocortical regions. The degree of GM loss was associated with extent of both memory complaints and performance deficits. Manually segmented hippocampal volumes, adjusted for age and intracranial volume, were significantly reduced only in the MCI group, with the CC group showing an intermediate level. CONCLUSIONS: Cognitive complaints in older adults may indicate underlying neurodegenerative changes even when unaccompanied by deficits on formal testing. The cognitive complaint group may represent a pre-mild cognitive impairment stage and may provide an earlier therapeutic opportunity than mild cognitive impairment. MRI analysis approaches incorporating signal intensity may have greater sensitivity in early preclinical stages than volumetric methods. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/16966547/Older_adults_with_cognitive_complaints_show_brain_atrophy_similar_to_that_of_amnestic_MCI_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=16966547 DB - PRIME DP - Unbound Medicine ER -