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The PediPump: development status of a new pediatric ventricular assist device: update II.
ASAIO J. 2006 Sep-Oct; 52(5):581-7.AJ

Abstract

The PediPump is a new ventricular assist device with a hydraulic output range designed for children from newborn infants to adolescents. The design is based on a mixed-flow rotary pump; the rotating assembly consists of a front impeller, front and rear radial magnetic bearings, and a central motor magnet. Two different implantable pumps were designed initially: an intravascular pump measuring 7 x 75 mm and an extravascular pump measuring 14 x 85 mm. Current prototypes are substantially smaller: The current intravascular version measures 4.5 x 55 mm, whereas the current extravascular version measures 11 x 70 mm. Both devices provide pressure and flows capable of supporting adults, far exceeding the initially defined physiologic requirements for children weighing 2 to 25 kg. This basic pump design may be used in acute or chronic clinical settings to provide right ventricular, left ventricular, or biventricular support. There are three objectives for the PediPump development program: 1) determination of basic engineering requirements for hardware and control logic including design analysis for system sizing, evaluation of control concepts, and bench testing of prototypes; 2) performance of preclinical anatomic fitting studies using CT-based 3D modeling; and 3) animal studies to provide characterization and reliability testing of the device.

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Authors+Show Affiliations

Duncan BW
Department of Pediatric and Congenital Heart Surgery, Children's Hospital, Cleveland Clinic, Cleveland, Ohio 44195, USA.
Dudzinski DT
No affiliation info available
Gu L
No affiliation info available
Mielke N
No affiliation info available
Noecker AM
No affiliation info available
Kopcak MW
No affiliation info available
Fukamachi K
No affiliation info available
Cingoz F
No affiliation info available
Ootaki Y
No affiliation info available
Smith WA
No affiliation info available

MeSH

AdolescentBiomedical EngineeringChildChild, PreschoolHeart-Assist DevicesHumansInfantInfant, NewbornProsthesis DesignProsthesis Fitting

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16966863

Citation

Duncan, Brian W., et al. "The PediPump: Development Status of a New Pediatric Ventricular Assist Device: Update II." ASAIO Journal (American Society for Artificial Internal Organs : 1992), vol. 52, no. 5, 2006, pp. 581-7.
Duncan BW, Dudzinski DT, Gu L, et al. The PediPump: development status of a new pediatric ventricular assist device: update II. ASAIO J. 2006;52(5):581-7.
Duncan, B. W., Dudzinski, D. T., Gu, L., Mielke, N., Noecker, A. M., Kopcak, M. W., Fukamachi, K., Cingoz, F., Ootaki, Y., & Smith, W. A. (2006). The PediPump: development status of a new pediatric ventricular assist device: update II. ASAIO Journal (American Society for Artificial Internal Organs : 1992), 52(5), 581-7.
Duncan BW, et al. The PediPump: Development Status of a New Pediatric Ventricular Assist Device: Update II. ASAIO J. 2006 Sep-Oct;52(5):581-7. PubMed PMID: 16966863.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The PediPump: development status of a new pediatric ventricular assist device: update II. AU - Duncan,Brian W, AU - Dudzinski,David T, AU - Gu,Lei, AU - Mielke,Nicole, AU - Noecker,Angela M, AU - Kopcak,Michael W, AU - Fukamachi,Kiyotaka, AU - Cingoz,Faruk, AU - Ootaki,Yoshio, AU - Smith,William A, PY - 2006/9/13/pubmed PY - 2006/12/19/medline PY - 2006/9/13/entrez SP - 581 EP - 7 JF - ASAIO journal (American Society for Artificial Internal Organs : 1992) JO - ASAIO J VL - 52 IS - 5 N2 - The PediPump is a new ventricular assist device with a hydraulic output range designed for children from newborn infants to adolescents. The design is based on a mixed-flow rotary pump; the rotating assembly consists of a front impeller, front and rear radial magnetic bearings, and a central motor magnet. Two different implantable pumps were designed initially: an intravascular pump measuring 7 x 75 mm and an extravascular pump measuring 14 x 85 mm. Current prototypes are substantially smaller: The current intravascular version measures 4.5 x 55 mm, whereas the current extravascular version measures 11 x 70 mm. Both devices provide pressure and flows capable of supporting adults, far exceeding the initially defined physiologic requirements for children weighing 2 to 25 kg. This basic pump design may be used in acute or chronic clinical settings to provide right ventricular, left ventricular, or biventricular support. There are three objectives for the PediPump development program: 1) determination of basic engineering requirements for hardware and control logic including design analysis for system sizing, evaluation of control concepts, and bench testing of prototypes; 2) performance of preclinical anatomic fitting studies using CT-based 3D modeling; and 3) animal studies to provide characterization and reliability testing of the device. SN - 1058-2916 UR - https://www.unboundmedicine.com/medline/citation/16966863/The_PediPump:_development_status_of_a_new_pediatric_ventricular_assist_device:_update_II_ L2 - https://doi.org/10.1097/01.mat.0000235821.63492.c4 DB - PRIME DP - Unbound Medicine ER -