TY - JOUR T1 - Antioxidant and antimutagenic properties of Hibiscus tiliaceus L. methanolic extract. AU - Rosa,Renato Moreira, AU - Melecchi,Maria Inés S, AU - da Costa Halmenschlager,Rafael, AU - Abad,Fernanda C, AU - Simoni,Cristina Rosat, AU - Caramão,Elina B, AU - Henriques,João Antonio Pêgas, AU - Saffi,Jenifer, AU - de Paula Ramos,Ana Lígia Lia, PY - 2006/9/14/pubmed PY - 2006/11/3/medline PY - 2006/9/14/entrez SP - 7324 EP - 30 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 54 IS - 19 N2 - The genus Hibiscus thrives in a variety of climates and produces a diversity of natural compounds with bioactive properties. We have studied the chemical composition and the in vivo antioxidant properties of Hibiscus tiliaceus L. methanolic flower extract, as well as its mutagenic/antimutagenic effects. Vitamin E and some stigmasterol derivatives that might confer an antioxidant effect to the extract were present. Treatment with this extract protected several Saccharomyces cerevisiae strains defective in antioxidant defenses against H2O2 and t-BOOH cytotoxicities, showing a clear antioxidant activity. The effect is the same for all strains used, independent of the antioxidant defense disrupted, suggesting that protection may be due to molecules that act as versatile and wide spectrum nonenzymatic antioxidants, such as vitamins or phytosterols. The extract was not mutagenic in either Salmonella typhimurium or S. cerevisiae and showed a significant antimutagenic action against oxidative mutagens in S. cerevisiae. SN - 0021-8561 UR - https://www.unboundmedicine.com/medline/citation/16968101/Antioxidant_and_antimutagenic_properties_of_Hibiscus_tiliaceus_L__methanolic_extract_ L2 - https://doi.org/10.1021/jf061407b DB - PRIME DP - Unbound Medicine ER -