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Perinatal risk factors and infantile autism.
Acta Psychiatr Scand. 2006 Oct; 114(4):257-64.AP

Abstract

OBJECTIVE

Suboptimal conditions during pregnancy and birth have been suggested as a cause of infantile autism. We have studied the association between obstetric factors and infantile autism.

METHOD

A population-based, matched case-control study of infantile autism. Conditional logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CI).

RESULTS

The risk of infantile autism was increased for mothers aged >35 years, with foreign citizenship, and mothers who used medicine during pregnancy. A higher risk of infantile autism was seen among children with low birth weight and with congenital malformations. Birth interventions, pathological cardiotocography, green amnion fluid and acidosis during delivery were not associated with increased risk for infantile autism.

CONCLUSION

Our findings suggest that suboptimal birth conditions are not an independent risk factor for infantile autism. A high prevalence of low birth weight and birth defects among autism cases seems to explain the suboptimal birth outcome.

Authors+Show Affiliations

Department of Epidemiology and Social Medicine, Institute of Public Health, University of Aarhus, Vennelyst Boulevard 6, 8000 Aarhus C, Denmark. rmai@soci.au.dkNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16968363

Citation

Maimburg, R D., and M Vaeth. "Perinatal Risk Factors and Infantile Autism." Acta Psychiatrica Scandinavica, vol. 114, no. 4, 2006, pp. 257-64.
Maimburg RD, Vaeth M. Perinatal risk factors and infantile autism. Acta Psychiatr Scand. 2006;114(4):257-64.
Maimburg, R. D., & Vaeth, M. (2006). Perinatal risk factors and infantile autism. Acta Psychiatrica Scandinavica, 114(4), 257-64.
Maimburg RD, Vaeth M. Perinatal Risk Factors and Infantile Autism. Acta Psychiatr Scand. 2006;114(4):257-64. PubMed PMID: 16968363.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Perinatal risk factors and infantile autism. AU - Maimburg,R D, AU - Vaeth,M, PY - 2006/9/14/pubmed PY - 2007/1/11/medline PY - 2006/9/14/entrez SP - 257 EP - 64 JF - Acta psychiatrica Scandinavica JO - Acta Psychiatr Scand VL - 114 IS - 4 N2 - OBJECTIVE: Suboptimal conditions during pregnancy and birth have been suggested as a cause of infantile autism. We have studied the association between obstetric factors and infantile autism. METHOD: A population-based, matched case-control study of infantile autism. Conditional logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CI). RESULTS: The risk of infantile autism was increased for mothers aged >35 years, with foreign citizenship, and mothers who used medicine during pregnancy. A higher risk of infantile autism was seen among children with low birth weight and with congenital malformations. Birth interventions, pathological cardiotocography, green amnion fluid and acidosis during delivery were not associated with increased risk for infantile autism. CONCLUSION: Our findings suggest that suboptimal birth conditions are not an independent risk factor for infantile autism. A high prevalence of low birth weight and birth defects among autism cases seems to explain the suboptimal birth outcome. SN - 0001-690X UR - https://www.unboundmedicine.com/medline/citation/16968363/Perinatal_risk_factors_and_infantile_autism_ L2 - https://doi.org/10.1111/j.1600-0447.2006.00805.x DB - PRIME DP - Unbound Medicine ER -