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Chinese herbal medicine Yin-Chen-Extract as an adjunct to anthelmintic albendazole used against Angiostrongylus cantonensis-induced eosinophilic meningitis or meningoencephalitis.
Am J Trop Med Hyg. 2006 Sep; 75(3):556-62.AJ

Abstract

The effects of albendazole and Yin-Chen-Extract co-therapy on Angiostrongylus cantonensis-induced eosinophilic meningitis in BALB/c mice were evaluated. Assay indicators for the therapeutic effect include worm recovery, histopathological score of the fourth ventricle, tissue-type plasminogen activator, urokinase-type plasminogen activator, matrix metalloproteinase-9, cerebrospinal fluid total protein, leukocyte counts, and proinflammatory cytokines. As a result, albendazole and Yin-Chen-Extract co-therapy significantly decreased (P < 0.05) these factors. Although Yin-Chen-Extract may possess pharmacologic activities beneficial to the inhibition of parasite-induced inflammation, many of these hypothetical benefits await scientific testing and confirmation before application. This study suggests that the combination of Yin-Chen-Extract and albendazole has synergistic effects in managing eosinophilic meningitis or eosinophilic meningoencephalitis.

Authors+Show Affiliations

Department of Parasitology, Chung Shan Medical University, Taiwan. shih@csmu.edu.tw

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16968941

Citation

Lai, Shih-Chan. "Chinese Herbal Medicine Yin-Chen-Extract as an Adjunct to Anthelmintic Albendazole Used Against Angiostrongylus Cantonensis-induced Eosinophilic Meningitis or Meningoencephalitis." The American Journal of Tropical Medicine and Hygiene, vol. 75, no. 3, 2006, pp. 556-62.
Lai SC. Chinese herbal medicine Yin-Chen-Extract as an adjunct to anthelmintic albendazole used against Angiostrongylus cantonensis-induced eosinophilic meningitis or meningoencephalitis. Am J Trop Med Hyg. 2006;75(3):556-62.
Lai, S. C. (2006). Chinese herbal medicine Yin-Chen-Extract as an adjunct to anthelmintic albendazole used against Angiostrongylus cantonensis-induced eosinophilic meningitis or meningoencephalitis. The American Journal of Tropical Medicine and Hygiene, 75(3), 556-62.
Lai SC. Chinese Herbal Medicine Yin-Chen-Extract as an Adjunct to Anthelmintic Albendazole Used Against Angiostrongylus Cantonensis-induced Eosinophilic Meningitis or Meningoencephalitis. Am J Trop Med Hyg. 2006;75(3):556-62. PubMed PMID: 16968941.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chinese herbal medicine Yin-Chen-Extract as an adjunct to anthelmintic albendazole used against Angiostrongylus cantonensis-induced eosinophilic meningitis or meningoencephalitis. A1 - Lai,Shih-Chan, PY - 2006/9/14/pubmed PY - 2006/10/26/medline PY - 2006/9/14/entrez SP - 556 EP - 62 JF - The American journal of tropical medicine and hygiene JO - Am J Trop Med Hyg VL - 75 IS - 3 N2 - The effects of albendazole and Yin-Chen-Extract co-therapy on Angiostrongylus cantonensis-induced eosinophilic meningitis in BALB/c mice were evaluated. Assay indicators for the therapeutic effect include worm recovery, histopathological score of the fourth ventricle, tissue-type plasminogen activator, urokinase-type plasminogen activator, matrix metalloproteinase-9, cerebrospinal fluid total protein, leukocyte counts, and proinflammatory cytokines. As a result, albendazole and Yin-Chen-Extract co-therapy significantly decreased (P < 0.05) these factors. Although Yin-Chen-Extract may possess pharmacologic activities beneficial to the inhibition of parasite-induced inflammation, many of these hypothetical benefits await scientific testing and confirmation before application. This study suggests that the combination of Yin-Chen-Extract and albendazole has synergistic effects in managing eosinophilic meningitis or eosinophilic meningoencephalitis. SN - 0002-9637 UR - https://www.unboundmedicine.com/medline/citation/16968941/Chinese_herbal_medicine_Yin_Chen_Extract_as_an_adjunct_to_anthelmintic_albendazole_used_against_Angiostrongylus_cantonensis_induced_eosinophilic_meningitis_or_meningoencephalitis_ L2 - https://medlineplus.gov/meningitis.html DB - PRIME DP - Unbound Medicine ER -