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Alcoholic neuropathy.
Curr Opin Neurol. 2006 Oct; 19(5):481-6.CO

Abstract

PURPOSE OF REVIEW

The concept of alcoholic neuropathy has been obscured because of an often undetected or overestimated influence of thiamine deficiency. We describe clinicopathologic features of alcoholic neuropathy, taking the effect of thiamine status into consideration, and recent progress associated with the pathogenesis.

RECENT FINDINGS

Clinical features of alcoholic neuropathy without thiamine deficiency are characterized by slowly progressive, sensory-dominant symptoms. Superficial sensation is predominantly impaired and painful symptoms are the major complaint. Pathologic features are characterized by small-fiber-predominant axonal loss. In contrast, the clinicopathologic features of alcoholic neuropathy with concomitant thiamine deficiency are variable, constituting a spectrum ranging from a picture of a pure form of alcoholic neuropathy to a presentation of nonalcoholic thiamine-deficiency neuropathy. One possible mediator of the direct neurotoxic effects among the metabolites of ethanol is acetaldehyde. Axonal transport and cytoskeletal properties are impaired by ethanol exposure. Protein kinase A and protein kinase C may also play a role in the pathogenesis, especially in association with painful symptoms.

SUMMARY

Nutritional deficiency as well as the direct neurotoxic effects of ethanol or its metabolites can cause alcoholic neuropathy. Although clinicopathologic features of the pure form of alcoholic neuropathy are uniform, they show extensive variation when thiamine deficiency is present.

Authors+Show Affiliations

Department of Neurology, Nagoya University, Graduate School of Medicine, Nagoya, Japan.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16969158

Citation

Koike, Haruki, and Gen Sobue. "Alcoholic Neuropathy." Current Opinion in Neurology, vol. 19, no. 5, 2006, pp. 481-6.
Koike H, Sobue G. Alcoholic neuropathy. Curr Opin Neurol. 2006;19(5):481-6.
Koike, H., & Sobue, G. (2006). Alcoholic neuropathy. Current Opinion in Neurology, 19(5), 481-6.
Koike H, Sobue G. Alcoholic Neuropathy. Curr Opin Neurol. 2006;19(5):481-6. PubMed PMID: 16969158.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcoholic neuropathy. AU - Koike,Haruki, AU - Sobue,Gen, PY - 2006/9/14/pubmed PY - 2007/2/23/medline PY - 2006/9/14/entrez SP - 481 EP - 6 JF - Current opinion in neurology JO - Curr. Opin. Neurol. VL - 19 IS - 5 N2 - PURPOSE OF REVIEW: The concept of alcoholic neuropathy has been obscured because of an often undetected or overestimated influence of thiamine deficiency. We describe clinicopathologic features of alcoholic neuropathy, taking the effect of thiamine status into consideration, and recent progress associated with the pathogenesis. RECENT FINDINGS: Clinical features of alcoholic neuropathy without thiamine deficiency are characterized by slowly progressive, sensory-dominant symptoms. Superficial sensation is predominantly impaired and painful symptoms are the major complaint. Pathologic features are characterized by small-fiber-predominant axonal loss. In contrast, the clinicopathologic features of alcoholic neuropathy with concomitant thiamine deficiency are variable, constituting a spectrum ranging from a picture of a pure form of alcoholic neuropathy to a presentation of nonalcoholic thiamine-deficiency neuropathy. One possible mediator of the direct neurotoxic effects among the metabolites of ethanol is acetaldehyde. Axonal transport and cytoskeletal properties are impaired by ethanol exposure. Protein kinase A and protein kinase C may also play a role in the pathogenesis, especially in association with painful symptoms. SUMMARY: Nutritional deficiency as well as the direct neurotoxic effects of ethanol or its metabolites can cause alcoholic neuropathy. Although clinicopathologic features of the pure form of alcoholic neuropathy are uniform, they show extensive variation when thiamine deficiency is present. SN - 1350-7540 UR - https://www.unboundmedicine.com/medline/citation/16969158/Alcoholic_neuropathy_ L2 - http://dx.doi.org/10.1097/01.wco.0000245371.89941.eb DB - PRIME DP - Unbound Medicine ER -
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