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The high-activity Val allele of the catechol-O-methyltransferase gene predicts greater cognitive deterioration in patients with psychosis.
Psychiatr Genet. 2006 Oct; 16(5):213-6.PG

Abstract

The objective of this study was to examine whether the functional genetic polymorphism Val158Met in the catechol-O-methyltransferase (COMT) gene influences cognitive deterioration in a sample of patients with psychosis under treatment with atypical antipsychotics. Eighty-seven patients with psychosis were genotyped for this polymorphism and were assessed with three Wechsler Adult Intelligence Scale (WAIS)-III subtests (Vocabulary, Information, and Digit Symbol-Coding). Performance on these three subtests was used to compute a 'cognitive deterioration index', and the effect of COMT genotype on this cognitive deterioration index was examined. A linear relationship between the number of Val alleles and the score on the cognitive deterioration index (i.e. the more Val alleles, the more cognitive deterioration) was observed. These results confirm the role of COMT genotype in the cognition of patients under treatment for psychosis, suggesting that it influences the extent of their cognitive deterioration.

Authors+Show Affiliations

Fundacion Argibide, Pamplona (Navarra), Spain. I.Mata@iop.kcl.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16969277

Citation

Mata, Ignacio, et al. "The High-activity Val Allele of the catechol-O-methyltransferase Gene Predicts Greater Cognitive Deterioration in Patients With Psychosis." Psychiatric Genetics, vol. 16, no. 5, 2006, pp. 213-6.
Mata I, Arranz MJ, Staddon S, et al. The high-activity Val allele of the catechol-O-methyltransferase gene predicts greater cognitive deterioration in patients with psychosis. Psychiatr Genet. 2006;16(5):213-6.
Mata, I., Arranz, M. J., Staddon, S., Lopez-Ilundain, J. M., Tabares-Seisdedos, R., & Murray, R. M. (2006). The high-activity Val allele of the catechol-O-methyltransferase gene predicts greater cognitive deterioration in patients with psychosis. Psychiatric Genetics, 16(5), 213-6.
Mata I, et al. The High-activity Val Allele of the catechol-O-methyltransferase Gene Predicts Greater Cognitive Deterioration in Patients With Psychosis. Psychiatr Genet. 2006;16(5):213-6. PubMed PMID: 16969277.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The high-activity Val allele of the catechol-O-methyltransferase gene predicts greater cognitive deterioration in patients with psychosis. AU - Mata,Ignacio, AU - Arranz,Maria J, AU - Staddon,Susan, AU - Lopez-Ilundain,Jose M, AU - Tabares-Seisdedos,Rafael, AU - Murray,Robin M, PY - 2006/9/14/pubmed PY - 2006/12/12/medline PY - 2006/9/14/entrez SP - 213 EP - 6 JF - Psychiatric genetics JO - Psychiatr. Genet. VL - 16 IS - 5 N2 - The objective of this study was to examine whether the functional genetic polymorphism Val158Met in the catechol-O-methyltransferase (COMT) gene influences cognitive deterioration in a sample of patients with psychosis under treatment with atypical antipsychotics. Eighty-seven patients with psychosis were genotyped for this polymorphism and were assessed with three Wechsler Adult Intelligence Scale (WAIS)-III subtests (Vocabulary, Information, and Digit Symbol-Coding). Performance on these three subtests was used to compute a 'cognitive deterioration index', and the effect of COMT genotype on this cognitive deterioration index was examined. A linear relationship between the number of Val alleles and the score on the cognitive deterioration index (i.e. the more Val alleles, the more cognitive deterioration) was observed. These results confirm the role of COMT genotype in the cognition of patients under treatment for psychosis, suggesting that it influences the extent of their cognitive deterioration. SN - 0955-8829 UR - https://www.unboundmedicine.com/medline/citation/16969277/The_high_activity_Val_allele_of_the_catechol_O_methyltransferase_gene_predicts_greater_cognitive_deterioration_in_patients_with_psychosis_ L2 - http://dx.doi.org/10.1097/01.ypg.0000218626.26622.a2 DB - PRIME DP - Unbound Medicine ER -