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Effects of hazelnut-enriched diet on plasma cholesterol and lipoprotein profiles in hypercholesterolemic adult men.
Eur J Clin Nutr. 2007 Feb; 61(2):212-20.EJ

Abstract

OBJECTIVE

Frequent consumption of nuts is associated with favorable plasma lipid profiles and reduced risk of coronary heart disease (CHD). This study was conducted to investigate the effects of hazelnut-enriched diet on plasma cholesterol and lipoprotein profiles in hypercholesterolemic adult men compared with baseline and control diet, and also to measure the anthropometric parameters, habitual physical activities, nutrient intake and endothelial function.

SUBJECTS AND DESIGN

Fifteen hypercholesterolemic men aged 48+/-8 years were recruited voluntarily. A well-controlled, 2-period (P1 and P2) study design with a total of 8-week was implemented. In the P1, subjects consumed a control diet (low-fat, low-cholesterol and high-carbohydrate). During the P2, the control diet was supplemented with MUFA-rich hazelnut (40 g/day), which provided 11.6% of total energy content. Anthropometric parameters and habitual physical activities were recorded. Plasma total and HDL cholesterol, TAG, ApoA-1, Apo B, total homocysteine and glucose concentrations were measured. All parameters and measurements were obtained at baseline and end of each 4-week diet period.

RESULTS

Body weights of subjects remained stable throughout the study. Compared with baseline, the hazelnut-enriched diet decreased (P<0.05) the concentrations of VLDL cholesterol, triacylglycerol, apolipoprotein B by 29.5, 31.8, and 9.2%, respectively, while increasing HDL cholesterol concentrations by 12.6%. Total/HDL cholesterol and LDL/HDL cholesterol ratios favorably decreased (P<0.05). Although insignificant there was a decreasing trend for the rest of parameters, particularly in total (5.2%) and LDL cholesterol (3.3%) in subjects consuming a hazelnut-enriched diet compared to that of the baseline. No changes were found in fasting levels of glucose, Apo A-1 and homocysteine between the control and hazelnut-enriched diets.

CONCLUSIONS

This study demonstrated that a high-fat and high-MUFA-rich hazelnut diet was superior to a low-fat control diet because of favorable changes in plasma lipid profiles of hypercholesterolemic adult men and, thereby positively affecting the CHD risk profile.

SPONSORSHIP

Funding provided by a grant from the Hazelnut Promotion Group, Giresun, Turkey.

Authors+Show Affiliations

Department of Nutrition and Dietetics, Hacettepe University, Ankara, Turkey. seyitmer@hacettepe.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16969381

Citation

Mercanligil, S M., et al. "Effects of Hazelnut-enriched Diet On Plasma Cholesterol and Lipoprotein Profiles in Hypercholesterolemic Adult Men." European Journal of Clinical Nutrition, vol. 61, no. 2, 2007, pp. 212-20.
Mercanligil SM, Arslan P, Alasalvar C, et al. Effects of hazelnut-enriched diet on plasma cholesterol and lipoprotein profiles in hypercholesterolemic adult men. Eur J Clin Nutr. 2007;61(2):212-20.
Mercanligil, S. M., Arslan, P., Alasalvar, C., Okut, E., Akgül, E., Pinar, A., Geyik, P. O., Tokgözoğlu, L., & Shahidi, F. (2007). Effects of hazelnut-enriched diet on plasma cholesterol and lipoprotein profiles in hypercholesterolemic adult men. European Journal of Clinical Nutrition, 61(2), 212-20.
Mercanligil SM, et al. Effects of Hazelnut-enriched Diet On Plasma Cholesterol and Lipoprotein Profiles in Hypercholesterolemic Adult Men. Eur J Clin Nutr. 2007;61(2):212-20. PubMed PMID: 16969381.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of hazelnut-enriched diet on plasma cholesterol and lipoprotein profiles in hypercholesterolemic adult men. AU - Mercanligil,S M, AU - Arslan,P, AU - Alasalvar,C, AU - Okut,E, AU - Akgül,E, AU - Pinar,A, AU - Geyik,P O, AU - Tokgözoğlu,L, AU - Shahidi,F, Y1 - 2006/09/13/ PY - 2006/9/14/pubmed PY - 2007/3/21/medline PY - 2006/9/14/entrez SP - 212 EP - 20 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 61 IS - 2 N2 - OBJECTIVE: Frequent consumption of nuts is associated with favorable plasma lipid profiles and reduced risk of coronary heart disease (CHD). This study was conducted to investigate the effects of hazelnut-enriched diet on plasma cholesterol and lipoprotein profiles in hypercholesterolemic adult men compared with baseline and control diet, and also to measure the anthropometric parameters, habitual physical activities, nutrient intake and endothelial function. SUBJECTS AND DESIGN: Fifteen hypercholesterolemic men aged 48+/-8 years were recruited voluntarily. A well-controlled, 2-period (P1 and P2) study design with a total of 8-week was implemented. In the P1, subjects consumed a control diet (low-fat, low-cholesterol and high-carbohydrate). During the P2, the control diet was supplemented with MUFA-rich hazelnut (40 g/day), which provided 11.6% of total energy content. Anthropometric parameters and habitual physical activities were recorded. Plasma total and HDL cholesterol, TAG, ApoA-1, Apo B, total homocysteine and glucose concentrations were measured. All parameters and measurements were obtained at baseline and end of each 4-week diet period. RESULTS: Body weights of subjects remained stable throughout the study. Compared with baseline, the hazelnut-enriched diet decreased (P<0.05) the concentrations of VLDL cholesterol, triacylglycerol, apolipoprotein B by 29.5, 31.8, and 9.2%, respectively, while increasing HDL cholesterol concentrations by 12.6%. Total/HDL cholesterol and LDL/HDL cholesterol ratios favorably decreased (P<0.05). Although insignificant there was a decreasing trend for the rest of parameters, particularly in total (5.2%) and LDL cholesterol (3.3%) in subjects consuming a hazelnut-enriched diet compared to that of the baseline. No changes were found in fasting levels of glucose, Apo A-1 and homocysteine between the control and hazelnut-enriched diets. CONCLUSIONS: This study demonstrated that a high-fat and high-MUFA-rich hazelnut diet was superior to a low-fat control diet because of favorable changes in plasma lipid profiles of hypercholesterolemic adult men and, thereby positively affecting the CHD risk profile. SPONSORSHIP: Funding provided by a grant from the Hazelnut Promotion Group, Giresun, Turkey. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/16969381/Effects_of_hazelnut_enriched_diet_on_plasma_cholesterol_and_lipoprotein_profiles_in_hypercholesterolemic_adult_men_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1602518 DB - PRIME DP - Unbound Medicine ER -