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Change in lean body mass is a major determinant of change in areal bone mineral density of the proximal femur: a 12-year observational study.
Calcif Tissue Int. 2006 Sep; 79(3):145-51.CT

Abstract

Our objective was to assess the contribution of lean body mass (LBM) and fat body mass (FBM) to areal bone mineral density (aBMD) in women during the years surrounding menopause. We used a 12-year observational design. Participants included 75 Caucasian women who were premenopausal, 53 of whom were available for follow-up. There were two measurement periods: baseline and 12-year follow-up. At both measurement periods, bone mineral content and aBMD of the proximal femur, posterior-anterior lumbar spine, and total body was assessed using dual-energy X-ray absorptiometry (DXA). LBM and FBM were derived from the total-body scans. General health, including current menopausal status, hormone replace therapy use, medication use, and physical activity, was assessed by questionnaires. At the end of the study, 44% of the women were postmenopausal. After controlling for baseline aBMD, current menopausal status, and current hormone replacement therapy, we found that change in LBM was independently associated with change in aBMD of the proximal femur (P = 0.001). The cross-sectional analyses also indicated that LBM was a significant determinant of aBMD of all three DXA-scanned sites at both baseline and follow-up. These novel longitudinal data highlight the important contribution of LBM to the maintenance of proximal femur bone mass at a key time in women's life span, the years surrounding menopause.

Authors+Show Affiliations

UBC Bone Health Research Group: Centre for Hip Health, BC Women's Hospital and Health Centre Osteoporosis Program, and Faculty of Medicine, University of British Columbia, 828 West 10th Avenue, Vancouver, BC, Canada, V5Z 1L8.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16969588

Citation

Liu-Ambrose, T, et al. "Change in Lean Body Mass Is a Major Determinant of Change in Areal Bone Mineral Density of the Proximal Femur: a 12-year Observational Study." Calcified Tissue International, vol. 79, no. 3, 2006, pp. 145-51.
Liu-Ambrose T, Kravetsky L, Bailey D, et al. Change in lean body mass is a major determinant of change in areal bone mineral density of the proximal femur: a 12-year observational study. Calcif Tissue Int. 2006;79(3):145-51.
Liu-Ambrose, T., Kravetsky, L., Bailey, D., Sherar, L., Mundt, C., Baxter-Jones, A., Khan, K. M., & McKay, H. A. (2006). Change in lean body mass is a major determinant of change in areal bone mineral density of the proximal femur: a 12-year observational study. Calcified Tissue International, 79(3), 145-51.
Liu-Ambrose T, et al. Change in Lean Body Mass Is a Major Determinant of Change in Areal Bone Mineral Density of the Proximal Femur: a 12-year Observational Study. Calcif Tissue Int. 2006;79(3):145-51. PubMed PMID: 16969588.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Change in lean body mass is a major determinant of change in areal bone mineral density of the proximal femur: a 12-year observational study. AU - Liu-Ambrose,T, AU - Kravetsky,L, AU - Bailey,D, AU - Sherar,L, AU - Mundt,C, AU - Baxter-Jones,A, AU - Khan,K M, AU - McKay,H A, Y1 - 2006/09/11/ PY - 2006/03/31/received PY - 2006/06/21/accepted PY - 2006/9/14/pubmed PY - 2006/11/15/medline PY - 2006/9/14/entrez SP - 145 EP - 51 JF - Calcified tissue international JO - Calcif. Tissue Int. VL - 79 IS - 3 N2 - Our objective was to assess the contribution of lean body mass (LBM) and fat body mass (FBM) to areal bone mineral density (aBMD) in women during the years surrounding menopause. We used a 12-year observational design. Participants included 75 Caucasian women who were premenopausal, 53 of whom were available for follow-up. There were two measurement periods: baseline and 12-year follow-up. At both measurement periods, bone mineral content and aBMD of the proximal femur, posterior-anterior lumbar spine, and total body was assessed using dual-energy X-ray absorptiometry (DXA). LBM and FBM were derived from the total-body scans. General health, including current menopausal status, hormone replace therapy use, medication use, and physical activity, was assessed by questionnaires. At the end of the study, 44% of the women were postmenopausal. After controlling for baseline aBMD, current menopausal status, and current hormone replacement therapy, we found that change in LBM was independently associated with change in aBMD of the proximal femur (P = 0.001). The cross-sectional analyses also indicated that LBM was a significant determinant of aBMD of all three DXA-scanned sites at both baseline and follow-up. These novel longitudinal data highlight the important contribution of LBM to the maintenance of proximal femur bone mass at a key time in women's life span, the years surrounding menopause. SN - 0171-967X UR - https://www.unboundmedicine.com/medline/citation/16969588/Change_in_lean_body_mass_is_a_major_determinant_of_change_in_areal_bone_mineral_density_of_the_proximal_femur:_a_12_year_observational_study_ L2 - https://dx.doi.org/10.1007/s00223-006-0098-z DB - PRIME DP - Unbound Medicine ER -