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Gargling with tea catechin extracts for the prevention of influenza infection in elderly nursing home residents: a prospective clinical study.

Abstract

OBJECTIVES

To evaluate the effects of gargling tea catechin extracts on the prevention of influenza infection in elderly nursing home residents.

DESIGN

A prospective study conducted for 3 months from January to March 2005.

SETTINGS/LOCATION

A nursing home in Japan.

SUBJECTS

A total of 124 elderly residents of at least 65 years of age were enrolled in the study. Seventy-six residents (83 +/-8.2 years, mean +/-standard deviation; 24 men, 52 women) gargled with tea catechin extract (catechin group) and were compared with 48 age- and sex-matched residents who gargled without tea catechin extracts (control group). All the residents were vaccinated with an influenza vaccine until early December 2004.

INTERVENTIONS

catechin group: gargling with the tea catechin extract solution (200 microg/mL catechins, 60% of catechins comprise epigallocatechin gallate); control group: gargling without the catechin extract solution. In both groups, gargling was performed three times daily for 3 months.

OUTCOME MEASURES

The incidence of influenza infection during the study was compared between the two groups. A safety evaluation was conducted to observe adverse events during the study.

RESULTS

The incidence of influenza infection was significantly lower in the catechin group (1.3%, one resident) than in the control group (10%, five residents) calculated by multivariate logistic regression analysis (p = 0.028; odds ratio, 15.711; 95% confidence interval, 1.883-399.658). No adverse events, such as respiratory tract irritation, an obstruction, or allergic bronchial spasm, were observed during the study.

CONCLUSIONS

This prospective study demonstrating the effect of catechin gargling on the prevention of influenza infection in the elderly is the first to be reported in the literature. Further randomized, controlled studies are needed to confirm the effects of catechin gargling on the prevention of influenza infection.

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  • Authors+Show Affiliations

    ,

    Division of Drug Evaluation & Informatics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan. hyamada@u-shizuoka-ken.ac.jp

    , ,

    Source

    MeSH

    Administration, Oral
    Aged
    Aged, 80 and over
    Anti-Infective Agents
    Catechin
    Cohort Studies
    Cross Infection
    Female
    Humans
    Influenza, Human
    Japan
    Male
    Nursing Homes
    Phytotherapy
    Plant Extracts
    Prospective Studies
    Tea
    Therapeutic Irrigation

    Pub Type(s)

    Controlled Clinical Trial
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16970537

    Citation

    Yamada, Hiroshi, et al. "Gargling With Tea Catechin Extracts for the Prevention of Influenza Infection in Elderly Nursing Home Residents: a Prospective Clinical Study." Journal of Alternative and Complementary Medicine (New York, N.Y.), vol. 12, no. 7, 2006, pp. 669-72.
    Yamada H, Takuma N, Daimon T, et al. Gargling with tea catechin extracts for the prevention of influenza infection in elderly nursing home residents: a prospective clinical study. J Altern Complement Med. 2006;12(7):669-72.
    Yamada, H., Takuma, N., Daimon, T., & Hara, Y. (2006). Gargling with tea catechin extracts for the prevention of influenza infection in elderly nursing home residents: a prospective clinical study. Journal of Alternative and Complementary Medicine (New York, N.Y.), 12(7), pp. 669-72.
    Yamada H, et al. Gargling With Tea Catechin Extracts for the Prevention of Influenza Infection in Elderly Nursing Home Residents: a Prospective Clinical Study. J Altern Complement Med. 2006;12(7):669-72. PubMed PMID: 16970537.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Gargling with tea catechin extracts for the prevention of influenza infection in elderly nursing home residents: a prospective clinical study. AU - Yamada,Hiroshi, AU - Takuma,Norikata, AU - Daimon,Takashi, AU - Hara,Yukihiko, PY - 2006/9/15/pubmed PY - 2007/1/11/medline PY - 2006/9/15/entrez SP - 669 EP - 72 JF - Journal of alternative and complementary medicine (New York, N.Y.) JO - J Altern Complement Med VL - 12 IS - 7 N2 - OBJECTIVES: To evaluate the effects of gargling tea catechin extracts on the prevention of influenza infection in elderly nursing home residents. DESIGN: A prospective study conducted for 3 months from January to March 2005. SETTINGS/LOCATION: A nursing home in Japan. SUBJECTS: A total of 124 elderly residents of at least 65 years of age were enrolled in the study. Seventy-six residents (83 +/-8.2 years, mean +/-standard deviation; 24 men, 52 women) gargled with tea catechin extract (catechin group) and were compared with 48 age- and sex-matched residents who gargled without tea catechin extracts (control group). All the residents were vaccinated with an influenza vaccine until early December 2004. INTERVENTIONS: catechin group: gargling with the tea catechin extract solution (200 microg/mL catechins, 60% of catechins comprise epigallocatechin gallate); control group: gargling without the catechin extract solution. In both groups, gargling was performed three times daily for 3 months. OUTCOME MEASURES: The incidence of influenza infection during the study was compared between the two groups. A safety evaluation was conducted to observe adverse events during the study. RESULTS: The incidence of influenza infection was significantly lower in the catechin group (1.3%, one resident) than in the control group (10%, five residents) calculated by multivariate logistic regression analysis (p = 0.028; odds ratio, 15.711; 95% confidence interval, 1.883-399.658). No adverse events, such as respiratory tract irritation, an obstruction, or allergic bronchial spasm, were observed during the study. CONCLUSIONS: This prospective study demonstrating the effect of catechin gargling on the prevention of influenza infection in the elderly is the first to be reported in the literature. Further randomized, controlled studies are needed to confirm the effects of catechin gargling on the prevention of influenza infection. SN - 1075-5535 UR - https://www.unboundmedicine.com/medline/citation/16970537/Gargling_with_tea_catechin_extracts_for_the_prevention_of_influenza_infection_in_elderly_nursing_home_residents:_a_prospective_clinical_study_ L2 - https://www.liebertpub.com/doi/full/10.1089/acm.2006.12.669?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -