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Deletion/insertion polymorphism of the angiotensin-converting enzyme gene and white matter hyperintensities in dementia: A pilot study.
J Am Geriatr Soc 2006; 54(9):1395-400JA

Abstract

OBJECTIVES

To examine the association between the angiotensin-converting enzyme (ACE) deletion/insertion (D/I) polymorphism and white matter hyperintensities (WMHs) in patients with dementia.

DESIGN

Observational pilot study with adjustment for potential confounders using analysis of covariance.

SETTING

Secondary care old-age psychiatry services in greater Manchester, United Kingdom.

PARTICIPANTS

Ninety-seven patients with dementia: 49 with Alzheimer's disease (AD, National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer's Disease and Related Disorders Association criteria) and 48 with vascular dementia (VaD, National Institute of Neurological Disorders and Stroke/Association Internationale pour la Recherche et l'Enseignement en Neurosciences criteria).

MEASUREMENTS

The ACE D/I polymorphism, WMHs (deep WMHs (DWMHs) and periventricular hyperintensities (PVHs)) on T2-weighted magnetic resonance imaging, and potential cardiovascular confounders.

RESULTS

The D/D polymorphism of the ACE genotype was associated with severity of DWMH (P = .005) but not PVH (P = .34), corrected for age, cardiovascular risk factors, and type of dementia. Post hoc analyses were limited by statistical power but suggested an interaction with the apolipoprotein E epsilon4 allele.

CONCLUSION

The results support previous observations that genetic factors influence the development of WMHs in dementia. The involvement of the ACE D/I polymorphism in the pathogenesis of DWMHs in dementia (AD and VaD), by a mechanism that is independent of its association with cardiovascular risk factors, should be confirmed in a large population-based sample.

Authors+Show Affiliations

Division of Psychiatry, Education and Research Center, South Manchester University Hospital, Manchester, United Kingdom. nitin.purandare@manchester.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16970648

Citation

Purandare, Nitin, et al. "Deletion/insertion Polymorphism of the Angiotensin-converting Enzyme Gene and White Matter Hyperintensities in Dementia: a Pilot Study." Journal of the American Geriatrics Society, vol. 54, no. 9, 2006, pp. 1395-400.
Purandare N, Oude Voshaar RC, Davidson Y, et al. Deletion/insertion polymorphism of the angiotensin-converting enzyme gene and white matter hyperintensities in dementia: A pilot study. J Am Geriatr Soc. 2006;54(9):1395-400.
Purandare, N., Oude Voshaar, R. C., Davidson, Y., Gibbons, L., Hardicre, J., Byrne, J., ... Mann, D. M. (2006). Deletion/insertion polymorphism of the angiotensin-converting enzyme gene and white matter hyperintensities in dementia: A pilot study. Journal of the American Geriatrics Society, 54(9), pp. 1395-400.
Purandare N, et al. Deletion/insertion Polymorphism of the Angiotensin-converting Enzyme Gene and White Matter Hyperintensities in Dementia: a Pilot Study. J Am Geriatr Soc. 2006;54(9):1395-400. PubMed PMID: 16970648.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Deletion/insertion polymorphism of the angiotensin-converting enzyme gene and white matter hyperintensities in dementia: A pilot study. AU - Purandare,Nitin, AU - Oude Voshaar,Richard C, AU - Davidson,Yvonne, AU - Gibbons,Linda, AU - Hardicre,Jayne, AU - Byrne,Jane, AU - McCollum,Charles, AU - Jackson,Alan, AU - Burns,Alistair, AU - Mann,David M A, PY - 2006/9/15/pubmed PY - 2006/10/21/medline PY - 2006/9/15/entrez SP - 1395 EP - 400 JF - Journal of the American Geriatrics Society JO - J Am Geriatr Soc VL - 54 IS - 9 N2 - OBJECTIVES: To examine the association between the angiotensin-converting enzyme (ACE) deletion/insertion (D/I) polymorphism and white matter hyperintensities (WMHs) in patients with dementia. DESIGN: Observational pilot study with adjustment for potential confounders using analysis of covariance. SETTING: Secondary care old-age psychiatry services in greater Manchester, United Kingdom. PARTICIPANTS: Ninety-seven patients with dementia: 49 with Alzheimer's disease (AD, National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer's Disease and Related Disorders Association criteria) and 48 with vascular dementia (VaD, National Institute of Neurological Disorders and Stroke/Association Internationale pour la Recherche et l'Enseignement en Neurosciences criteria). MEASUREMENTS: The ACE D/I polymorphism, WMHs (deep WMHs (DWMHs) and periventricular hyperintensities (PVHs)) on T2-weighted magnetic resonance imaging, and potential cardiovascular confounders. RESULTS: The D/D polymorphism of the ACE genotype was associated with severity of DWMH (P = .005) but not PVH (P = .34), corrected for age, cardiovascular risk factors, and type of dementia. Post hoc analyses were limited by statistical power but suggested an interaction with the apolipoprotein E epsilon4 allele. CONCLUSION: The results support previous observations that genetic factors influence the development of WMHs in dementia. The involvement of the ACE D/I polymorphism in the pathogenesis of DWMHs in dementia (AD and VaD), by a mechanism that is independent of its association with cardiovascular risk factors, should be confirmed in a large population-based sample. SN - 0002-8614 UR - https://www.unboundmedicine.com/medline/citation/16970648/Deletion/insertion_polymorphism_of_the_angiotensin_converting_enzyme_gene_and_white_matter_hyperintensities_in_dementia:_A_pilot_study_ L2 - https://doi.org/10.1111/j.1532-5415.2006.00841.x DB - PRIME DP - Unbound Medicine ER -