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Increase in adhesion molecules in cerebrospinal fluid of children with mumps and mumps meningitis.
Scand J Immunol. 2006 Oct; 64(4):420-4.SJ

Abstract

Adhesion molecules play a key role in leucocyte migration into the central nervous system (CNS). Concentrations of endothelial-derived soluble intercellular adhesion molecule-1 (sICAM-1) and leucocyte-originated soluble L-selectin (sL-selectin) in cerebrospinal fluid (CSF) of children with mumps meningitis (mononuclear pleocytosis, n = 33) and mumps (absence of pleocytosis, n = 9) were compared with values from age-matched control group (n = 19). In 14 patients from the meningitis group, adhesion molecule levels together with albumin concentration were estimated in paired CSF/serum samples to calculate concentration quotients and determine molecule intrathecal release. Both sICAM-1 (median 3.44 versus 0.86 ng/ml; P < 0.0001) and sL-selectin (median 29.91 versus 8.52 ng/ml; P < 0.0001) concentrations in CSF were increased in mumps meningitis patients compared with controls. Increased levels of the selected adhesion molecules were also observed in mumps patients without CNS involvement when compared with controls (median sICAM-1: 1.14 versus 0.86 ng/ml, sL-selectin: 13.54 versus 8.52 ng/ml; P < 0.01). Additionally, the concentration of adhesion molecules was found to correlate with CSF leucocyte count. Considerable correlation of sICAM-1 and sL-selectin quotients and corresponding albumin quotients suggests that a majority of the soluble adhesion molecules originated from the bloodstream. Analysis of adhesion molecule levels demonstrated indirect evidence of brain-derived fractions. Our results suggest the involvement of adhesion molecules during the early phase of mumps meningitis.

Authors+Show Affiliations

Department of Pediatric Infectious Diseases, Medical University of Bialystok, Bialystok, Poland.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16970684

Citation

Sulik, A, et al. "Increase in Adhesion Molecules in Cerebrospinal Fluid of Children With Mumps and Mumps Meningitis." Scandinavian Journal of Immunology, vol. 64, no. 4, 2006, pp. 420-4.
Sulik A, Wojtkowska M, Rozkiewicz D, et al. Increase in adhesion molecules in cerebrospinal fluid of children with mumps and mumps meningitis. Scand J Immunol. 2006;64(4):420-4.
Sulik, A., Wojtkowska, M., Rozkiewicz, D., & Oldak, E. (2006). Increase in adhesion molecules in cerebrospinal fluid of children with mumps and mumps meningitis. Scandinavian Journal of Immunology, 64(4), 420-4.
Sulik A, et al. Increase in Adhesion Molecules in Cerebrospinal Fluid of Children With Mumps and Mumps Meningitis. Scand J Immunol. 2006;64(4):420-4. PubMed PMID: 16970684.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increase in adhesion molecules in cerebrospinal fluid of children with mumps and mumps meningitis. AU - Sulik,A, AU - Wojtkowska,M, AU - Rozkiewicz,D, AU - Oldak,E, PY - 2006/9/15/pubmed PY - 2006/11/1/medline PY - 2006/9/15/entrez SP - 420 EP - 4 JF - Scandinavian journal of immunology JO - Scand J Immunol VL - 64 IS - 4 N2 - Adhesion molecules play a key role in leucocyte migration into the central nervous system (CNS). Concentrations of endothelial-derived soluble intercellular adhesion molecule-1 (sICAM-1) and leucocyte-originated soluble L-selectin (sL-selectin) in cerebrospinal fluid (CSF) of children with mumps meningitis (mononuclear pleocytosis, n = 33) and mumps (absence of pleocytosis, n = 9) were compared with values from age-matched control group (n = 19). In 14 patients from the meningitis group, adhesion molecule levels together with albumin concentration were estimated in paired CSF/serum samples to calculate concentration quotients and determine molecule intrathecal release. Both sICAM-1 (median 3.44 versus 0.86 ng/ml; P < 0.0001) and sL-selectin (median 29.91 versus 8.52 ng/ml; P < 0.0001) concentrations in CSF were increased in mumps meningitis patients compared with controls. Increased levels of the selected adhesion molecules were also observed in mumps patients without CNS involvement when compared with controls (median sICAM-1: 1.14 versus 0.86 ng/ml, sL-selectin: 13.54 versus 8.52 ng/ml; P < 0.01). Additionally, the concentration of adhesion molecules was found to correlate with CSF leucocyte count. Considerable correlation of sICAM-1 and sL-selectin quotients and corresponding albumin quotients suggests that a majority of the soluble adhesion molecules originated from the bloodstream. Analysis of adhesion molecule levels demonstrated indirect evidence of brain-derived fractions. Our results suggest the involvement of adhesion molecules during the early phase of mumps meningitis. SN - 0300-9475 UR - https://www.unboundmedicine.com/medline/citation/16970684/Increase_in_adhesion_molecules_in_cerebrospinal_fluid_of_children_with_mumps_and_mumps_meningitis_ L2 - https://doi.org/10.1111/j.1365-3083.2006.01797.x DB - PRIME DP - Unbound Medicine ER -