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Iris colour, optic disc dimensions, degree and progression of glaucomatous optic nerve damage.
Clin Exp Ophthalmol. 2006 Sep-Oct; 34(7):654-60.CE

Abstract

PURPOSE

To evaluate whether iris colour influences size and shape of the optic nerve head and risk for glaucoma progression.

METHODS

The hospital-based observational study included 1973 eyes of 1012 Caucasian subjects with ocular hypertension or chronic open-angle glaucoma. For all patients, colour stereo optic disc photographs were evaluated, and corneal pachymetry and achromatic perimetry were performed. Main outcome measures were optic nerve head parameters, the development or progression of visual field defects and iris colour.

RESULTS

In most of the study groups, size of the optic disc, neuroretinal rim, alpha zone and beta zone of parapapillary atrophy, retinal vessel diameter and central corneal thickness did not differ significantly between eyes with blue, green, brown and mixed iris colour. In the normal-pressure glaucoma group, neuroretinal rim area was smallest in the population with mixed-coloured eyes and largest in the group of eyes with brown irides (P = 0.001 after correction for inter-eye dependency and multiple testing). For the ocular hypertensive subjects and glaucoma patients with follow-up examinations, the rate of development or progression of glaucomatous visual field loss was not significantly associated with iris colour (P = 0.060).

CONCLUSIONS

In Caucasian subjects, iris colour does not have a major association with the size of the optic nerve head structures, central corneal thickness and retinal arterial diameter. In Caucasian patients with ocular hypertension or chronic open-angle glaucoma, an influence of iris colour on the risk for development or progression of glaucomatous visual field defects could not be confirmed.

Authors+Show Affiliations

Department of Ophthalmology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany. Jost.Jonas@augen.ma.uni-heidelberg.deNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16970758

Citation

Jonas, Jost B., et al. "Iris Colour, Optic Disc Dimensions, Degree and Progression of Glaucomatous Optic Nerve Damage." Clinical & Experimental Ophthalmology, vol. 34, no. 7, 2006, pp. 654-60.
Jonas JB, Budde WM, Stroux A, et al. Iris colour, optic disc dimensions, degree and progression of glaucomatous optic nerve damage. Clin Exp Ophthalmol. 2006;34(7):654-60.
Jonas, J. B., Budde, W. M., Stroux, A., & Oberacher-Velten, I. M. (2006). Iris colour, optic disc dimensions, degree and progression of glaucomatous optic nerve damage. Clinical & Experimental Ophthalmology, 34(7), 654-60.
Jonas JB, et al. Iris Colour, Optic Disc Dimensions, Degree and Progression of Glaucomatous Optic Nerve Damage. Clin Exp Ophthalmol. 2006 Sep-Oct;34(7):654-60. PubMed PMID: 16970758.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Iris colour, optic disc dimensions, degree and progression of glaucomatous optic nerve damage. AU - Jonas,Jost B, AU - Budde,Wido M, AU - Stroux,Andrea, AU - Oberacher-Velten,Isabel M, PY - 2006/9/15/pubmed PY - 2006/11/15/medline PY - 2006/9/15/entrez SP - 654 EP - 60 JF - Clinical & experimental ophthalmology JO - Clin Exp Ophthalmol VL - 34 IS - 7 N2 - PURPOSE: To evaluate whether iris colour influences size and shape of the optic nerve head and risk for glaucoma progression. METHODS: The hospital-based observational study included 1973 eyes of 1012 Caucasian subjects with ocular hypertension or chronic open-angle glaucoma. For all patients, colour stereo optic disc photographs were evaluated, and corneal pachymetry and achromatic perimetry were performed. Main outcome measures were optic nerve head parameters, the development or progression of visual field defects and iris colour. RESULTS: In most of the study groups, size of the optic disc, neuroretinal rim, alpha zone and beta zone of parapapillary atrophy, retinal vessel diameter and central corneal thickness did not differ significantly between eyes with blue, green, brown and mixed iris colour. In the normal-pressure glaucoma group, neuroretinal rim area was smallest in the population with mixed-coloured eyes and largest in the group of eyes with brown irides (P = 0.001 after correction for inter-eye dependency and multiple testing). For the ocular hypertensive subjects and glaucoma patients with follow-up examinations, the rate of development or progression of glaucomatous visual field loss was not significantly associated with iris colour (P = 0.060). CONCLUSIONS: In Caucasian subjects, iris colour does not have a major association with the size of the optic nerve head structures, central corneal thickness and retinal arterial diameter. In Caucasian patients with ocular hypertension or chronic open-angle glaucoma, an influence of iris colour on the risk for development or progression of glaucomatous visual field defects could not be confirmed. SN - 1442-6404 UR - https://www.unboundmedicine.com/medline/citation/16970758/Iris_colour_optic_disc_dimensions_degree_and_progression_of_glaucomatous_optic_nerve_damage_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=16970758.ui DB - PRIME DP - Unbound Medicine ER -