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NMDA antagonist MK-801 impairs acquisition of place strategies, but not their use.
Behav Brain Res. 2006 Nov 25; 175(1):112-8.BB

Abstract

Evidence that NMDA receptors contribute to synaptic plasticity in the hippocampus has stimulated research on their role in behavioral learning and memory. Recent studies indicate that NMDA antagonists decrease use of place strategies by rats in a T-maze task that can be solved using either a "place" or "response" strategy. In the present study, rats were given MK-801 before maze exposure and/or training on this redundant strategy T-maze task. MK-801 did not impair rats' ability to learn the task, but did change the strategies they used on a probe trial administered after learning. MK-801 decreased use of place strategies only when administered before both maze exposure and training; rats given MK-801 only before maze exposure or only before training tended to use place strategies on the probe trial. These results show that MK-801 does not prevent rats from utilizing previously acquired spatial information, but does appear to impair the acquisition of spatial information needed for place strategies.

Authors+Show Affiliations

Department of Psychology, Radford University, Radford, VA 24142, USA. jmackes1@jhmi.eduNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16970996

Citation

Mackes, Jennifer L., and Jeffrey Willner. "NMDA Antagonist MK-801 Impairs Acquisition of Place Strategies, but Not Their Use." Behavioural Brain Research, vol. 175, no. 1, 2006, pp. 112-8.
Mackes JL, Willner J. NMDA antagonist MK-801 impairs acquisition of place strategies, but not their use. Behav Brain Res. 2006;175(1):112-8.
Mackes, J. L., & Willner, J. (2006). NMDA antagonist MK-801 impairs acquisition of place strategies, but not their use. Behavioural Brain Research, 175(1), 112-8.
Mackes JL, Willner J. NMDA Antagonist MK-801 Impairs Acquisition of Place Strategies, but Not Their Use. Behav Brain Res. 2006 Nov 25;175(1):112-8. PubMed PMID: 16970996.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - NMDA antagonist MK-801 impairs acquisition of place strategies, but not their use. AU - Mackes,Jennifer L, AU - Willner,Jeffrey, Y1 - 2006/09/12/ PY - 2006/08/04/received PY - 2006/08/09/accepted PY - 2006/9/15/pubmed PY - 2007/1/4/medline PY - 2006/9/15/entrez SP - 112 EP - 8 JF - Behavioural brain research JO - Behav Brain Res VL - 175 IS - 1 N2 - Evidence that NMDA receptors contribute to synaptic plasticity in the hippocampus has stimulated research on their role in behavioral learning and memory. Recent studies indicate that NMDA antagonists decrease use of place strategies by rats in a T-maze task that can be solved using either a "place" or "response" strategy. In the present study, rats were given MK-801 before maze exposure and/or training on this redundant strategy T-maze task. MK-801 did not impair rats' ability to learn the task, but did change the strategies they used on a probe trial administered after learning. MK-801 decreased use of place strategies only when administered before both maze exposure and training; rats given MK-801 only before maze exposure or only before training tended to use place strategies on the probe trial. These results show that MK-801 does not prevent rats from utilizing previously acquired spatial information, but does appear to impair the acquisition of spatial information needed for place strategies. SN - 0166-4328 UR - https://www.unboundmedicine.com/medline/citation/16970996/NMDA_antagonist_MK_801_impairs_acquisition_of_place_strategies_but_not_their_use_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(06)00455-4 DB - PRIME DP - Unbound Medicine ER -