Tags

Type your tag names separated by a space and hit enter

6-Gingerol prevents cisplatin-induced acute renal failure in rats.
Biofactors. 2006; 26(3):189-200.B

Abstract

BACKGROUND

Nephrotoxicity is a major complication and a dose limiting factor for cisplatin therapy. Recent evidence suggests that enhanced oxidative stress caused by oxygen-centered free radicals may contribute to the pathogenesis of cisplatin-induced acute renal failure. 6-Gingerol is claimed to be a potent antioxidant. The present study was performed to explore the renoprotective potential of 6-gingerol on cisplatin-induced oxidative stress and renal dysfunction.

METHODS

6-Gingerol in dosages of 12.5, 25, 50 mg/kg was administered 2 days before and 3 days after cisplatin administration. Renal injury was assessed by measuring serum creatinine, blood urea nitrogen, creatinine, urea clearance and serum nitrite levels. Renal oxidative stress was assessed by determining renal malondialdehyde levels, reduced glutathione levels and enzymatic activities of superoxide dismutase and catalase.

RESULTS

A single dose of cisplatin resulted in marked renal oxidative and nitrosative stress and significantly deranged renal functions. 6-Gingerol treatment significantly and dose-dependently restored renal functions, reduced lipid peroxidation and enhanced the levels of reduced glutathione and activities of superoxide dismutase and catalase.

CONCLUSIONS

The present study demonstrates the renoprotective potential of 6-gingerol against cisplatin-induced oxidative stress and renal dysfunction in rats. Hence, 6-gingerol has a potential to be used as therapeutic adjuvant in cisplatin nephrotoxicity.

Authors+Show Affiliations

Pharmacology division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16971750

Citation

Kuhad, Anurag, et al. "6-Gingerol Prevents Cisplatin-induced Acute Renal Failure in Rats." BioFactors (Oxford, England), vol. 26, no. 3, 2006, pp. 189-200.
Kuhad A, Tirkey N, Pilkhwal S, et al. 6-Gingerol prevents cisplatin-induced acute renal failure in rats. Biofactors. 2006;26(3):189-200.
Kuhad, A., Tirkey, N., Pilkhwal, S., & Chopra, K. (2006). 6-Gingerol prevents cisplatin-induced acute renal failure in rats. BioFactors (Oxford, England), 26(3), 189-200.
Kuhad A, et al. 6-Gingerol Prevents Cisplatin-induced Acute Renal Failure in Rats. Biofactors. 2006;26(3):189-200. PubMed PMID: 16971750.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 6-Gingerol prevents cisplatin-induced acute renal failure in rats. AU - Kuhad,Anurag, AU - Tirkey,Naveen, AU - Pilkhwal,Sangeeta, AU - Chopra,Kanwaljit, PY - 2006/9/15/pubmed PY - 2007/1/11/medline PY - 2006/9/15/entrez SP - 189 EP - 200 JF - BioFactors (Oxford, England) JO - Biofactors VL - 26 IS - 3 N2 - BACKGROUND: Nephrotoxicity is a major complication and a dose limiting factor for cisplatin therapy. Recent evidence suggests that enhanced oxidative stress caused by oxygen-centered free radicals may contribute to the pathogenesis of cisplatin-induced acute renal failure. 6-Gingerol is claimed to be a potent antioxidant. The present study was performed to explore the renoprotective potential of 6-gingerol on cisplatin-induced oxidative stress and renal dysfunction. METHODS: 6-Gingerol in dosages of 12.5, 25, 50 mg/kg was administered 2 days before and 3 days after cisplatin administration. Renal injury was assessed by measuring serum creatinine, blood urea nitrogen, creatinine, urea clearance and serum nitrite levels. Renal oxidative stress was assessed by determining renal malondialdehyde levels, reduced glutathione levels and enzymatic activities of superoxide dismutase and catalase. RESULTS: A single dose of cisplatin resulted in marked renal oxidative and nitrosative stress and significantly deranged renal functions. 6-Gingerol treatment significantly and dose-dependently restored renal functions, reduced lipid peroxidation and enhanced the levels of reduced glutathione and activities of superoxide dismutase and catalase. CONCLUSIONS: The present study demonstrates the renoprotective potential of 6-gingerol against cisplatin-induced oxidative stress and renal dysfunction in rats. Hence, 6-gingerol has a potential to be used as therapeutic adjuvant in cisplatin nephrotoxicity. SN - 0951-6433 UR - https://www.unboundmedicine.com/medline/citation/16971750/6_Gingerol_prevents_cisplatin_induced_acute_renal_failure_in_rats_ L2 - https://content.iospress.com/openurl?genre=article&issn=0951-6433&volume=26&issue=3&spage=189 DB - PRIME DP - Unbound Medicine ER -