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Metabolic and polycystic ovary syndromes in indigenous South Asian women with previous gestational diabetes mellitus.
BJOG 2006; 113(10):1182-7BJOG

Abstract

OBJECTIVE

To determine the risk of metabolic syndrome (MS) and polycystic ovary syndrome (PCOS) in a cohort of indigenous South Asian women with a recent history of gestational diabetes mellitus (GDM).

DESIGN

Case-control study.

SETTING

Department of Obstetrics & Gynaecology, University of Colombo, Sri Lanka.

SAMPLE

Two hundred and seventy-four indigenous Sri Lankan women with previous GDM and 168 ethnically matched controls. Of these, 147 with previous GDM and 67 controls not taking hormonal contraception participated in an in-depth endocrine study.

METHODS

Assessing the prevalence of MS and PCOS based on clinical features, biochemistry and ovarian ultrasound examination at 3 years postpartum.

MAIN OUTCOME MEASURES

Prevalence of MS and PCOS.

RESULTS

Women with previous GDM and controls were studied at a mean (range) of 34.6 (13.4-84.1) and 46.5 (17.5-78) months postpartum, respectively. Those with previous GDM had a larger mean +/- 95% confidence interval waist circumference (90.9 +/- 1.3 versus 81.2 +/- 2.8 cm, P = 0.0004) and were more likely to have hypertension (17.6 versus 7.4%, P = 0.001), glucose intolerance (51.7 versus 10.4%, P = 0.00001), hypertriglyceridaemia (16.3 versus 5.9%, P = 0.02) and a lower level of high-density lipoprotein (70 versus 56.7%, P = 0.04) than the controls. Of the women who had GDM, 72 (49%) had MS, 86 (58.5%) had polycystic ovaries and 59 (40%) had PCOS, significantly more than the control women-4 (6%), 9 (13%) and 2 (3%), respectively (P = 0.00001).

CONCLUSIONS

The prevalence of MS and PCOS in indigenous Sri Lankan women 3 years postpartum is significantly higher in those with previous GDM compared with ethnically matched controls. This confirms an association between GDM and subsequent PCOS and MS.

Authors+Show Affiliations

Department of Obstetrics & Gynaecology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka. mandika59@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16972862

Citation

Wijeyaratne, C N., et al. "Metabolic and Polycystic Ovary Syndromes in Indigenous South Asian Women With Previous Gestational Diabetes Mellitus." BJOG : an International Journal of Obstetrics and Gynaecology, vol. 113, no. 10, 2006, pp. 1182-7.
Wijeyaratne CN, Waduge R, Arandara D, et al. Metabolic and polycystic ovary syndromes in indigenous South Asian women with previous gestational diabetes mellitus. BJOG. 2006;113(10):1182-7.
Wijeyaratne, C. N., Waduge, R., Arandara, D., Arasalingam, A., Sivasuriam, A., Dodampahala, S. H., & Balen, A. H. (2006). Metabolic and polycystic ovary syndromes in indigenous South Asian women with previous gestational diabetes mellitus. BJOG : an International Journal of Obstetrics and Gynaecology, 113(10), pp. 1182-7.
Wijeyaratne CN, et al. Metabolic and Polycystic Ovary Syndromes in Indigenous South Asian Women With Previous Gestational Diabetes Mellitus. BJOG. 2006;113(10):1182-7. PubMed PMID: 16972862.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic and polycystic ovary syndromes in indigenous South Asian women with previous gestational diabetes mellitus. AU - Wijeyaratne,C N, AU - Waduge,R, AU - Arandara,D, AU - Arasalingam,A, AU - Sivasuriam,A, AU - Dodampahala,S H, AU - Balen,A H, PY - 2006/9/16/pubmed PY - 2006/11/15/medline PY - 2006/9/16/entrez SP - 1182 EP - 7 JF - BJOG : an international journal of obstetrics and gynaecology JO - BJOG VL - 113 IS - 10 N2 - OBJECTIVE: To determine the risk of metabolic syndrome (MS) and polycystic ovary syndrome (PCOS) in a cohort of indigenous South Asian women with a recent history of gestational diabetes mellitus (GDM). DESIGN: Case-control study. SETTING: Department of Obstetrics & Gynaecology, University of Colombo, Sri Lanka. SAMPLE: Two hundred and seventy-four indigenous Sri Lankan women with previous GDM and 168 ethnically matched controls. Of these, 147 with previous GDM and 67 controls not taking hormonal contraception participated in an in-depth endocrine study. METHODS: Assessing the prevalence of MS and PCOS based on clinical features, biochemistry and ovarian ultrasound examination at 3 years postpartum. MAIN OUTCOME MEASURES: Prevalence of MS and PCOS. RESULTS: Women with previous GDM and controls were studied at a mean (range) of 34.6 (13.4-84.1) and 46.5 (17.5-78) months postpartum, respectively. Those with previous GDM had a larger mean +/- 95% confidence interval waist circumference (90.9 +/- 1.3 versus 81.2 +/- 2.8 cm, P = 0.0004) and were more likely to have hypertension (17.6 versus 7.4%, P = 0.001), glucose intolerance (51.7 versus 10.4%, P = 0.00001), hypertriglyceridaemia (16.3 versus 5.9%, P = 0.02) and a lower level of high-density lipoprotein (70 versus 56.7%, P = 0.04) than the controls. Of the women who had GDM, 72 (49%) had MS, 86 (58.5%) had polycystic ovaries and 59 (40%) had PCOS, significantly more than the control women-4 (6%), 9 (13%) and 2 (3%), respectively (P = 0.00001). CONCLUSIONS: The prevalence of MS and PCOS in indigenous Sri Lankan women 3 years postpartum is significantly higher in those with previous GDM compared with ethnically matched controls. This confirms an association between GDM and subsequent PCOS and MS. SN - 1470-0328 UR - https://www.unboundmedicine.com/medline/citation/16972862/Metabolic_and_polycystic_ovary_syndromes_in_indigenous_South_Asian_women_with_previous_gestational_diabetes_mellitus_ L2 - https://doi.org/10.1111/j.1471-0528.2006.01046.x DB - PRIME DP - Unbound Medicine ER -