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PCOS according to the Rotterdam consensus criteria: Change in prevalence among WHO-II anovulation and association with metabolic factors.
BJOG. 2006 Oct; 113(10):1210-7.BJOG

Abstract

OBJECTIVE

The current report aims to compare the prevalence of polycystic ovary syndrome (PCOS) diagnosed according to the new Rotterdam criteria (Rott-PCOS) versus the previous criteria as formulated by the National Institutes of Health (NIH) (NIH-PCOS) in women with normogonadotropic (WHO-II) anovulation and assess the frequency of obesity and related factors determined in these women.

DESIGN

Cohort study based on large anovulation screening database.

SETTING

Two large tertiary referral centres for reproductive medicine.

POPULATION

WHO-II normogonadotropic, anovulatory, infertility cases.

METHODS

WHO-II cases were extracted from the screening database and classified according to both the Rotterdam and NIH criteria for PCOS. Within these two classes, the prevalence of obesity, hyperglycaemia and insulin resistance was assessed and compared and their relation to the difference in diagnostic criteria applied was analysed.

MAIN OUTCOME MEASURES

Prevalence of diagnosis PCOS in the WHO-II anovulation group. Prevalence of obesity, hyperglycaemia and insulin resistance in the two diagnostic classes.

RESULTS

The Rott-PCOS group appeared to be more than 1.5 times larger than the group classified as NIH-PCOS (91 versus 55% of the WHO-II cohort). Especially, women with ovarian dysfunction and polycystic ovaries at ultrasound scan, but without hyperandrogenism, were added to the PCOS diagnostic group. The Rott-PCOS exhibited a lower frequency of obesity, hyperglycaemia and insulin resistance compared with the NIH-PCOS group. Obese women in the Rott-PCOS group without androgen excess had a different metabolic profile compared with obese women in the NIH-PCOS group, with lower rates of hyperglycaemia and hyperinsulinism, despite comparable distributions of body weight.

CONCLUSION

The present findings indicate that with the new Rotterdam consensus criteria, oligo/anovulatory women with less severe metabolic derangement will be added to the heterogeneous group of women with PCOS.

Authors+Show Affiliations

Department of Reproductive Medicine and Gynaecology, University Medical Centre, Utrecht, The Netherlands. f.broekmans@azu.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

16972863

Citation

Broekmans, F J., et al. "PCOS According to the Rotterdam Consensus Criteria: Change in Prevalence Among WHO-II Anovulation and Association With Metabolic Factors." BJOG : an International Journal of Obstetrics and Gynaecology, vol. 113, no. 10, 2006, pp. 1210-7.
Broekmans FJ, Knauff EA, Valkenburg O, et al. PCOS according to the Rotterdam consensus criteria: Change in prevalence among WHO-II anovulation and association with metabolic factors. BJOG. 2006;113(10):1210-7.
Broekmans, F. J., Knauff, E. A., Valkenburg, O., Laven, J. S., Eijkemans, M. J., & Fauser, B. C. (2006). PCOS according to the Rotterdam consensus criteria: Change in prevalence among WHO-II anovulation and association with metabolic factors. BJOG : an International Journal of Obstetrics and Gynaecology, 113(10), 1210-7.
Broekmans FJ, et al. PCOS According to the Rotterdam Consensus Criteria: Change in Prevalence Among WHO-II Anovulation and Association With Metabolic Factors. BJOG. 2006;113(10):1210-7. PubMed PMID: 16972863.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - PCOS according to the Rotterdam consensus criteria: Change in prevalence among WHO-II anovulation and association with metabolic factors. AU - Broekmans,F J, AU - Knauff,E A H, AU - Valkenburg,O, AU - Laven,J S, AU - Eijkemans,M J, AU - Fauser,B C J M, PY - 2006/9/16/pubmed PY - 2006/11/15/medline PY - 2006/9/16/entrez SP - 1210 EP - 7 JF - BJOG : an international journal of obstetrics and gynaecology JO - BJOG VL - 113 IS - 10 N2 - OBJECTIVE: The current report aims to compare the prevalence of polycystic ovary syndrome (PCOS) diagnosed according to the new Rotterdam criteria (Rott-PCOS) versus the previous criteria as formulated by the National Institutes of Health (NIH) (NIH-PCOS) in women with normogonadotropic (WHO-II) anovulation and assess the frequency of obesity and related factors determined in these women. DESIGN: Cohort study based on large anovulation screening database. SETTING: Two large tertiary referral centres for reproductive medicine. POPULATION: WHO-II normogonadotropic, anovulatory, infertility cases. METHODS: WHO-II cases were extracted from the screening database and classified according to both the Rotterdam and NIH criteria for PCOS. Within these two classes, the prevalence of obesity, hyperglycaemia and insulin resistance was assessed and compared and their relation to the difference in diagnostic criteria applied was analysed. MAIN OUTCOME MEASURES: Prevalence of diagnosis PCOS in the WHO-II anovulation group. Prevalence of obesity, hyperglycaemia and insulin resistance in the two diagnostic classes. RESULTS: The Rott-PCOS group appeared to be more than 1.5 times larger than the group classified as NIH-PCOS (91 versus 55% of the WHO-II cohort). Especially, women with ovarian dysfunction and polycystic ovaries at ultrasound scan, but without hyperandrogenism, were added to the PCOS diagnostic group. The Rott-PCOS exhibited a lower frequency of obesity, hyperglycaemia and insulin resistance compared with the NIH-PCOS group. Obese women in the Rott-PCOS group without androgen excess had a different metabolic profile compared with obese women in the NIH-PCOS group, with lower rates of hyperglycaemia and hyperinsulinism, despite comparable distributions of body weight. CONCLUSION: The present findings indicate that with the new Rotterdam consensus criteria, oligo/anovulatory women with less severe metabolic derangement will be added to the heterogeneous group of women with PCOS. SN - 1470-0328 UR - https://www.unboundmedicine.com/medline/citation/16972863/PCOS_according_to_the_Rotterdam_consensus_criteria:_Change_in_prevalence_among_WHO_II_anovulation_and_association_with_metabolic_factors_ L2 - https://doi.org/10.1111/j.1471-0528.2006.01008.x DB - PRIME DP - Unbound Medicine ER -