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Chronic psychological distress and risk of Alzheimer's disease in old age.
Neuroepidemiology 2006; 27(3):143-53N

Abstract

Clinical and pathological data from the Rush Memory and Aging Project were used to test the hypothesis that distress proneness is associated with increased risk of Alzheimer's disease (AD). More than 600 older persons without dementia completed a 6-item measure of neuroticism, a stable indicator of proneness to psychological distress. At annual intervals thereafter, they underwent uniform evaluations that included clinical classification of AD and administration of 18 cognitive tests. Those who died underwent brain autopsy from which composite measures of AD pathology were derived. During a mean of about 3 years of follow-up, 55 people were clinically diagnosed with AD. In analyses that controlled for age, sex, and education, persons with a high level of distress proneness (score = 24, 90th percentile) were 2.7 times more likely to develop AD than those not prone to distress (score = 6, 10th percentile). Adjustment for depressive symptomatology or frequency of cognitive, social, and physical activity did not substantially change this effect. Distress proneness was also associated with more rapid cognitive decline. Among 45 participants who died and underwent brain autopsy, distress proneness was unrelated to diverse measures of AD pathology and was inversely related to cognition after controlling for AD pathology. The results support the hypothesis that distress proneness is associated with increased risk of dementia and suggest that neurobiologic mechanisms other than AD pathology may underlie the association.

Authors+Show Affiliations

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Ill, USA. rwilson@rush.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16974109

Citation

Wilson, Robert S., et al. "Chronic Psychological Distress and Risk of Alzheimer's Disease in Old Age." Neuroepidemiology, vol. 27, no. 3, 2006, pp. 143-53.
Wilson RS, Arnold SE, Schneider JA, et al. Chronic psychological distress and risk of Alzheimer's disease in old age. Neuroepidemiology. 2006;27(3):143-53.
Wilson, R. S., Arnold, S. E., Schneider, J. A., Kelly, J. F., Tang, Y., & Bennett, D. A. (2006). Chronic psychological distress and risk of Alzheimer's disease in old age. Neuroepidemiology, 27(3), pp. 143-53.
Wilson RS, et al. Chronic Psychological Distress and Risk of Alzheimer's Disease in Old Age. Neuroepidemiology. 2006;27(3):143-53. PubMed PMID: 16974109.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic psychological distress and risk of Alzheimer's disease in old age. AU - Wilson,Robert S, AU - Arnold,Steven E, AU - Schneider,Julie A, AU - Kelly,Jeremiah F, AU - Tang,Yuxiao, AU - Bennett,David A, Y1 - 2006/09/13/ PY - 2006/9/16/pubmed PY - 2006/12/21/medline PY - 2006/9/16/entrez SP - 143 EP - 53 JF - Neuroepidemiology JO - Neuroepidemiology VL - 27 IS - 3 N2 - Clinical and pathological data from the Rush Memory and Aging Project were used to test the hypothesis that distress proneness is associated with increased risk of Alzheimer's disease (AD). More than 600 older persons without dementia completed a 6-item measure of neuroticism, a stable indicator of proneness to psychological distress. At annual intervals thereafter, they underwent uniform evaluations that included clinical classification of AD and administration of 18 cognitive tests. Those who died underwent brain autopsy from which composite measures of AD pathology were derived. During a mean of about 3 years of follow-up, 55 people were clinically diagnosed with AD. In analyses that controlled for age, sex, and education, persons with a high level of distress proneness (score = 24, 90th percentile) were 2.7 times more likely to develop AD than those not prone to distress (score = 6, 10th percentile). Adjustment for depressive symptomatology or frequency of cognitive, social, and physical activity did not substantially change this effect. Distress proneness was also associated with more rapid cognitive decline. Among 45 participants who died and underwent brain autopsy, distress proneness was unrelated to diverse measures of AD pathology and was inversely related to cognition after controlling for AD pathology. The results support the hypothesis that distress proneness is associated with increased risk of dementia and suggest that neurobiologic mechanisms other than AD pathology may underlie the association. SN - 0251-5350 UR - https://www.unboundmedicine.com/medline/citation/16974109/Chronic_psychological_distress_and_risk_of_Alzheimer's_disease_in_old_age_ L2 - https://www.karger.com?DOI=10.1159/000095761 DB - PRIME DP - Unbound Medicine ER -