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Hypothalamic-pituitary-adrenocortical (HPA) activity in kindergarten children: importance of gender and associations with behavioral/emotional difficulties.
J Psychiatr Res. 2007 Nov; 41(10):861-70.JP

Abstract

The current cross-sectional study investigated basal and stress-challenged hypothalamic-pituitary-adrenocortical (HPA) system function in 102 five-year old kindergarten children (59 boys, 43 girls) who had been assessed by a comprehensive psychological and behavioral test battery. Baseline HPA system activity was significantly increased in girls when compared to boys (p<0.001). Furthermore, basal HPA system activity predicted a high hormonal release during stress with--again--girls showing higher hormonal responses than boys (p<0.01). Importantly, increased HPA system activity (baseline and stress-challenged) was significantly associated with hyperactivity/impulsivity and emotional problems in boys and with positive emotions in girls (p<0.05). These results suggest an occurrence of neurobiological alterations early in development. The observed neurobiological changes are gender specific already at the age of 5 years. Prospective long-term follow up of the identified subjects with HPA axis alterations will clarify if these markers are predictive for the onset of psychiatric disorders.

Authors+Show Affiliations

Psychiatric University Clinics (UPK), Depression Research Unit, Wilhelm Klein-Str. 27, CH-4025 Basel, Switzerland. christine.haselbach@upkbs.chNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16979188

Citation

Hatzinger, Martin, et al. "Hypothalamic-pituitary-adrenocortical (HPA) Activity in Kindergarten Children: Importance of Gender and Associations With Behavioral/emotional Difficulties." Journal of Psychiatric Research, vol. 41, no. 10, 2007, pp. 861-70.
Hatzinger M, Brand S, Perren S, et al. Hypothalamic-pituitary-adrenocortical (HPA) activity in kindergarten children: importance of gender and associations with behavioral/emotional difficulties. J Psychiatr Res. 2007;41(10):861-70.
Hatzinger, M., Brand, S., Perren, S., von Wyl, A., von Klitzing, K., & Holsboer-Trachsler, E. (2007). Hypothalamic-pituitary-adrenocortical (HPA) activity in kindergarten children: importance of gender and associations with behavioral/emotional difficulties. Journal of Psychiatric Research, 41(10), 861-70.
Hatzinger M, et al. Hypothalamic-pituitary-adrenocortical (HPA) Activity in Kindergarten Children: Importance of Gender and Associations With Behavioral/emotional Difficulties. J Psychiatr Res. 2007;41(10):861-70. PubMed PMID: 16979188.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypothalamic-pituitary-adrenocortical (HPA) activity in kindergarten children: importance of gender and associations with behavioral/emotional difficulties. AU - Hatzinger,Martin, AU - Brand,Serge, AU - Perren,Sonja, AU - von Wyl,Agnes, AU - von Klitzing,Kai, AU - Holsboer-Trachsler,Edith, Y1 - 2006/09/18/ PY - 2006/05/11/received PY - 2006/07/17/revised PY - 2006/07/24/accepted PY - 2006/9/19/pubmed PY - 2007/8/10/medline PY - 2006/9/19/entrez SP - 861 EP - 70 JF - Journal of psychiatric research JO - J Psychiatr Res VL - 41 IS - 10 N2 - The current cross-sectional study investigated basal and stress-challenged hypothalamic-pituitary-adrenocortical (HPA) system function in 102 five-year old kindergarten children (59 boys, 43 girls) who had been assessed by a comprehensive psychological and behavioral test battery. Baseline HPA system activity was significantly increased in girls when compared to boys (p<0.001). Furthermore, basal HPA system activity predicted a high hormonal release during stress with--again--girls showing higher hormonal responses than boys (p<0.01). Importantly, increased HPA system activity (baseline and stress-challenged) was significantly associated with hyperactivity/impulsivity and emotional problems in boys and with positive emotions in girls (p<0.05). These results suggest an occurrence of neurobiological alterations early in development. The observed neurobiological changes are gender specific already at the age of 5 years. Prospective long-term follow up of the identified subjects with HPA axis alterations will clarify if these markers are predictive for the onset of psychiatric disorders. SN - 0022-3956 UR - https://www.unboundmedicine.com/medline/citation/16979188/Hypothalamic_pituitary_adrenocortical__HPA__activity_in_kindergarten_children:_importance_of_gender_and_associations_with_behavioral/emotional_difficulties_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3956(06)00150-6 DB - PRIME DP - Unbound Medicine ER -