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Role of alpha-tocopherol on antioxidant status in liver, lung and kidney of PCB exposed male albino rats.
Food Chem Toxicol. 2006 Dec; 44(12):2040-6.FC

Abstract

Polychlorinated biphenyls (PCB) are widespread, lipophilic environmental pollutants which have been identified as contaminants in almost every component of the global ecosystem including fish, wildlife, and human adipose tissue, breast milk, and serum. Several studies have shown that PCBs can cause oxidative damage to biomolecules, in the form of lipid peroxidation, modulation of antioxidant enzymes, and oxidative stress. In the present study, we have sought to investigate the effects of alpha-tocopherol (vitamin E) on antioxidant status of PCB-induced toxicity in male Wistar rats. The protective effect of alpha-tocopherol (50mg/kg body weight/day) was tested in PCB-induced toxicity in rat liver, lung, and kidney. We report here that the oral supplementation of alpha-tocopherol was found to maintain the cellular redox status by maintaining the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase accompanied with glutathione and vitamin E levels and down regulation in the levels of lipid peroxides, hydroxyl radical and hydrogen peroxides generation in PCB treated rats. Therefore, our present study demonstrates the PCB-induced deficits in antioxidant enzyme activities and increase in reactive oxygen species and lipid peroxidation levels in liver, kidney, and lung which can be overcome through simultaneous supplementation with alpha-tocopherol.

Authors+Show Affiliations

Department of Endocrinology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai 600 113, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16979807

Citation

Banudevi, Sivanantham, et al. "Role of Alpha-tocopherol On Antioxidant Status in Liver, Lung and Kidney of PCB Exposed Male Albino Rats." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 44, no. 12, 2006, pp. 2040-6.
Banudevi S, Krishnamoorthy G, Venkataraman P, et al. Role of alpha-tocopherol on antioxidant status in liver, lung and kidney of PCB exposed male albino rats. Food Chem Toxicol. 2006;44(12):2040-6.
Banudevi, S., Krishnamoorthy, G., Venkataraman, P., Vignesh, C., Aruldhas, M. M., & Arunakaran, J. (2006). Role of alpha-tocopherol on antioxidant status in liver, lung and kidney of PCB exposed male albino rats. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 44(12), 2040-6.
Banudevi S, et al. Role of Alpha-tocopherol On Antioxidant Status in Liver, Lung and Kidney of PCB Exposed Male Albino Rats. Food Chem Toxicol. 2006;44(12):2040-6. PubMed PMID: 16979807.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of alpha-tocopherol on antioxidant status in liver, lung and kidney of PCB exposed male albino rats. AU - Banudevi,Sivanantham, AU - Krishnamoorthy,Gunasekaran, AU - Venkataraman,Prabhu, AU - Vignesh,Chandraganth, AU - Aruldhas,Maria Michael, AU - Arunakaran,Jagadeesan, Y1 - 2006/08/10/ PY - 2005/08/27/received PY - 2006/06/27/revised PY - 2006/07/06/accepted PY - 2006/9/19/pubmed PY - 2006/12/15/medline PY - 2006/9/19/entrez SP - 2040 EP - 6 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 44 IS - 12 N2 - Polychlorinated biphenyls (PCB) are widespread, lipophilic environmental pollutants which have been identified as contaminants in almost every component of the global ecosystem including fish, wildlife, and human adipose tissue, breast milk, and serum. Several studies have shown that PCBs can cause oxidative damage to biomolecules, in the form of lipid peroxidation, modulation of antioxidant enzymes, and oxidative stress. In the present study, we have sought to investigate the effects of alpha-tocopherol (vitamin E) on antioxidant status of PCB-induced toxicity in male Wistar rats. The protective effect of alpha-tocopherol (50mg/kg body weight/day) was tested in PCB-induced toxicity in rat liver, lung, and kidney. We report here that the oral supplementation of alpha-tocopherol was found to maintain the cellular redox status by maintaining the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase accompanied with glutathione and vitamin E levels and down regulation in the levels of lipid peroxides, hydroxyl radical and hydrogen peroxides generation in PCB treated rats. Therefore, our present study demonstrates the PCB-induced deficits in antioxidant enzyme activities and increase in reactive oxygen species and lipid peroxidation levels in liver, kidney, and lung which can be overcome through simultaneous supplementation with alpha-tocopherol. SN - 0278-6915 UR - https://www.unboundmedicine.com/medline/citation/16979807/Role_of_alpha_tocopherol_on_antioxidant_status_in_liver_lung_and_kidney_of_PCB_exposed_male_albino_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(06)00191-8 DB - PRIME DP - Unbound Medicine ER -